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71.
Imai Kaoru Hagi Akifumi Inoue Yasuhide Amarasiri Mohan Sano Daisuke 《Food and environmental virology》2020,12(2):180-190
Food and Environmental Virology - Human noroviruses are the major cause of non-bacterial acute gastroenteritis worldwide. Since no therapeutic agent has been proven to prevent human norovirus... 相似文献
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John Ibhagbemien Anetor Hideki Wanibuchi Min Wei Anna Kakehsshi Jin Seok Kang 《毒物与环境化学》2013,95(7):1339-1351
There is a dearth of data on the initiation activity of dimethylarsinic acid (DMA (V)), a major metabolite of the ubiquitous environmental and occupational carcinogen and toxicant, arsenic (As). The initiation activity of DMA (V) was investigated on rat hepatocarcinogenesis with liver being a major target organ for As-induced carcinogenicity. A total of 50 rats at 10 weeks old were randomly divided in a nine-week medium-term bioassay into four groups. Groups 1 and 2 received 200 ppm of DMA (V) in drinking water for four weeks while groups 3 and 4 drank only tap water until the sixth week when groups 1 and 3 were given 0.01% 2-acetylaminofluorene (2-AAF) in their diet for two weeks in the promotion stage. All animals were subjected to two-third partial hepatectomy (PH) at the seventh week. Quantitative analysis of glutathione S-transferase placental form (GST-P) positive foci in liver, a pre-neoplastic marker of rat hepatocarcinogenesis, demonstrated higher numbers in group 1 (DMA (V) + 2-AAF) than 3 (2-AAF alone) at foci consisting of two–four cells and 15 or a greater number of cells. The numbers of GST-P positive foci consisting of five–nine cells were significantly higher in group 1 than 3. Foci consisting of 10–14 cells were also higher but not significantly different. The GST-P positive foci were apparently similar in groups 2 and 4. Expression of total GST-P positive foci was significantly higher in group 1 compared to 2, 3 or 4. The proliferating cell nuclear antigen (PCNA) test performed to clarify the apparent trend of GST-P data revealed significantly higher PCNA index in group 1. Data indicate weak initiation potential of DMA (V) and for the first time appear to provide evidence for initiation activity in DMA (V)-induced hepatocarcinogenesis in rats. 相似文献
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Taguchi Shigeru Hagiwara Moe Shibata Ayumi Fujinari Hiroaki Matsumoto Sayaka Kuwata Makoto Sazawa Kazuto Hata Noriko Kuramitz Hideki 《Environmental science and pollution research international》2021,28(11):13425-13438
Environmental Science and Pollution Research - Formaldehyde (HCHO) is a naturally occurring compound found in ambient air which can induce cancer and sick-building syndrome. It plays an important... 相似文献
76.
Nakao Keisuke Suto Hitoshi Hattori Yasuo Kikumoto Hideki 《Environmental Fluid Mechanics》2022,22(4):663-682
Environmental Fluid Mechanics - This study applies the models describing the effect of a neutrally stratified high-Reynolds-number boundary layer on peak wind estimation. A neutrally stratified... 相似文献