Drugs from marine organisms

A modern approach to the search for biologically active substances of potential therapeutic use isolated from marine organisms is illustrated by a presentation of the multidisciplinary project pursued by the Roche Research Institute of Marine Pharmacology near Sydney, Australia. This specialized insitute is part of the world-wide research endeavour of our company and has now been in operation for five years. Following a brief outline of the technical functions the main scientific achievements published by the scientists of the institute are reviewed. This institute is, to our knowledge, the only one of its kind in private industry and we have attempted to demonstrate how its activities should be viewed in the overall context of today's drug or product development.     

Variationen der Nährstoff-und Schwermetallgehalte in Böden

This article investigates the variations of nutrient (phosphorus (P) and potassium (K)) and heavy metal contents in soils. Therefore, selected regions in Eifel and Hunsrueck (region around Trier) were examined. The data base consists of more than 100.000 existing measurements plus own investigations on the main land use classes —field, grassland, vinicultural areas and forest—with regard to their intensities (conventional und biological). The evaluation of the nutrient contents for P and K was made using the manual adequate fertilization for field and grassland. The creation of heavy metal distribution maps is based on the Kriging method. In the past, soils in the region of Trier received a too large amount of P and K—especially in vinicultural areas. Mineral and organic fertilization has a great influence on the heavy metal contents on farmland. The immission of dust contaminated with heavy met|als is important on forest and grassland locations. On vineyards the use of cupreous plant protection agents is critical. The land use classes have had a substantial influence on the nutrient and heavy metal contents of the soil. In contrast to this, the intensities showed less differences. In order to reduce the anthropogenic impact on heavy metals in soils, it is necessary to create specific reduction strategies for each land use class. For example the fertilization has to be limited to the need of the plant, contaminated secondary raw material fertilizer has to be avoid the comparability of analytical methods has to be ensured.