Cholestyramine enhances fecal elimination of pentachlorophenol in rhesus monkeys

The effect of cholestyramine in the daily diet upon the excretion of pentachlorophenol with the feces was studied in the rhesus monkey. The treatment increased fecal elimination of pentachlorophenol and/or metabolites up to 9- to 14-fold over a six-day period. At the same time urinary excretion was reduced 2- to 6-fold. The data suggest that cholestyramine interrupts the enterhepatic circulation of PCP and/or metabolites thus indicating its possible usefulness in preventing toxicity of PCP that otherwise may occur due to reabsorption of biliary PCP and/or metabolites.     

Neutrino Physics at the Dawn of the Twenty-First Century

   Neutrino Physics in recent decades has undergone a rapid growth and has evolved into a discipline of relevance for various research fields, ranging from geophysics to cosmology. On the other hand, however, the knowledge that we have about the neutrino itself, i.e., its very nature and intrinsic properties, is still rather fragmentary. This article summarizes the present status of pure and applied neutrino physics, emphasizing on pointing out the links to neighboring disciplines.     

Re-thinking water policy priorities in the Mediterranean region in view of climate change

Water is scarce in Mediterranean countries: cities are crowded with increasing demand; food is produced with large amounts of water; ecosystems demand more water that is often available; drought affects all. As climate change impacts become more noticeable and costlier, some current water management strategies will not be useful. According to the findings of CIRCE, the areas with limited water resources will increase in the coming decades with major consequences for the way we produce food and we protect ecosystems. Based on these projections this paper discusses water policy priorities for climate change adaptation in the Mediterranean. We first summarise the main challenges to water resources in Mediterranean countries and outline the risks and opportunities for water under climate change based on previous studies. Recognising the difficulty to go from precipitation to water policy, we then present a framework to evaluate water availability in response to natural and management conditions, with an example of application in the Ebro basin that exemplifies other Mediterranean areas. Then we evaluate adaptive capacity to understand the ability of Mediterranean countries to face, respond and recover from climate change impacts on water resources. Social and economic factors are key drivers of inequality in the adaptive capacity across the region. Based on the assessment of impacts and adaptive capacity we suggest thresholds for water policy to respond to climate change and link water scarcity indicators to relevant potential adaptation strategies. Our results suggest the need to further prioritise socially and economically sensitive policies.     

Storm impacts along European coastlines. Part 1: The joint effort of the MICORE and ConHaz Projects

The current paper discusses the topic of marine storm impact along European coastlines, presenting results from two FP7 Projects currently focusing on this topic, one working on the physical aspects of the problem (MICORE) and the other one on the socio-economic implications (ConHaz).The MICORE Project aims to provide on-line predictions of storm-related physical hazards (hydrodynamic as well as morphodynamic). The ConHaz Project addresses the socio-economic implications should these (or other) hazards actually materialize. Together these projects aim to deliver crucial information for emergency response efforts, while realizing the practical limitations for information processing and dissemination during crisis situations.The MICORE Project has developed and demonstrated on-line tools for reliable predictions of the morphological impact of marine storm events in support of civil protection mitigation strategies. The project specifically targeted the development of early warning and information systems to support short term emergency response in case of an extreme storm event. The current paper discusses in detail the outcome of an activity of databasing historical storm data. No clear changes in storminess were observed, except for some storm proxies (e.g. surges) and only at some locations (e.g. northern Adriatic, southern Baltic, etc.).The ConHaz Project undertook a desktop study of the methods normally used for evaluating the impact of marine storms and the associated coastal hazards considering direct costs, costs due to disruption of production processes, indirect costs, intangible costs, and costs of adaptation and mitigation measures. Several methods for cost estimation were reviewed. From the review it emerged that normally end-users only evaluate direct costs after the storms, while the cost of adaptation and mitigation measures is only done strategically in the context of Integrated Coastal Zone Management plans. As there is no standardized method for cost evaluations in this field, it is suggested that clear guidelines should be produced on the basis of simplicity for use by end-users. The integration between historical databases of the physical parameters of storms and detailed cost evaluation information would support the development of a knowledge background in end-users and justify the development of adaptation strategies.     

Water purification by sulfide-containing activated carbon

We investigated a new kind of activated carbon named gaiasafe-Formstoff [1] as an agent for powerful heavy metal reduction. This activated carbon contains highly dispersed sulfide compounds. Our investigations with lead containing wastewaters showed an outstanding metal sulfide precipitation power of the new agent. The lead reduction rates are independent of wastewater parameters like lead concentration and complexing agent concentration. Contacted as powder or as a fixed bed with wastewater gaiasafe-Formstoff showed the best cleaning capacity in comparison to all other agents tested. Investigations with gaiasafe-Formstoff about its ability to reduce the contents of further heavy metals in wastewater are under way. The gaiasafe-Formstoff reaction products with wastewater represent an energy-rich and raw material-rich resource when fed to metallurgical processes.     

Toxicity, dioxin-like activities, and endocrine effects of DDT metabolites—DDA, DDMU, DDMS, and DDCN

Background, aim, and scope  

2,2-bis(chlorophenyl)-1,1,1-trichloroethane (DDT) metabolites, other than those routinely measured [i.e., 2,2-bis(chlorophenyl)-1,1-dichloroethylene (DDE) and 2,2-bis(chlorophenyl)-1,1-dichloroethane (DDD)], have recently been detected in elevated concentrations not only in the surface water of Teltow Canal, Berlin, but also in sediment samples from Elbe tributaries (e.g., Mulde and Havel/Spree). This was paralleled by recent reports that multiple other metabolites could emerge from the degradation of parent DDT by naturally occurring organisms or by interaction with some heavy metals. Nevertheless, only very few data on the biological activities of these metabolites are available to date. The objective of this communication is to evaluate, for the first time, the cytotoxicity, dioxin-like activity, and estrogenicity of the least-studied DDT metabolites.     

Occupant injury severity from lateral collisions: A literature review

Problem

Side impacts are a serious automotive injury problem; they represent about 30% of all fatalities for passenger vehicle occupants. This literature review focuses on occupant injuries resulting from real lateral collisions. It emphasizes the interaction between injury patterns and crash factors, taking into account type of injuries and their severity. It highlights what is known on the subject and suggests further studies.

Method

We reviewed papers identified by searches in two electronic databases for the 1996-2009 publication period, and in specific journals and conference proceedings.

Results

Studies on the Primary Direction of Force (PDOF) have revealed that fatal crashes occur most frequently when the PDOF is at 3 or 9 o'clock. The risk of serious injury is two to three times higher for the near-side occupant than for the far-side occupant. Head injuries predominate in oblique impacts and thoracic injuries in perpendicular ones. A few results are also reported on side airbag protection.

Conclusions

This literature review presents an overall picture of the injuries caused by lateral collisions, though each of the papers or articles examined focuses mostly on some particular aspect of the problem. The incidence of specific injuries depends on the data source used. Very few population-based analyses of lateral collision injuries were found.

Impact on industry

New studies are needed to evaluate new protective devices (e.g., lateral airbags, inflatable curtains). Without interfering with their care duties, Emergency Medical Technicians could be systematically trained to observe the collision's specific characteristics and to report all their relevant observations to the emergency physicians to increase the likelihood of prompt diagnosis and proper care.     

Taxi driver seat belt wearing in Nanjing, China

Objective

To determine and validate patterns of seat belt use and attitudes of taxi drivers on wearing a seat belt following national and provincial seat belt legislation in 2004-2005. Design: Roadside daylight seat belt observation and interview survey methods were used, as well as observations from inside taxis during routine trips and a taxi driver focus group. The setting was Nanjing, Jiangsu Province, PR China in April of 2006 and 2007.

Main outcome measures

Prevalence of seat belt use and attitudes to wearing a seat belt were determined, as were vehicle and driver characteristics, and comparisons with other motor-vehicle driver's seat belt use and attitudes.

Results

Taxi drivers interviewed were predominantly male and aged 30-39 years. They spent more hours per week in their vehicles and had more driving experience than other drivers. Over half (56.2%) of taxi drivers interviewed reported that they always wore seat belts, while observation of taxi drivers showed lower wearing rates (i.e., roadside observation was 43.8%, and observation from inside taxis was 36.2%). Belt tampering was a practice of 12-15% of taxi drivers. “Fine avoidance, safety, high speed and long trips” were given as important reasons for wearing and “feeling trapped and uncomfortable” for not wearing. Seat belt reminder signs in taxis were common (82.6% of taxis), but did not appear to impact on driver seat belt use.

Conclusion

The four research methods found taxi drivers to have consistently low “correct wearing” rates.

Impact on industry

As in several other countries, taxi drivers are particularly resistant to seat belt use. Innovative strategies, including occupational health and safety approaches, may be required to achieve increased levels of seat belt use.     

Poverty as a determinant of young drivers' fatal crash risks

Problem

U.S. teenaged and young-adult drivers' elevated rates of fatal traffic crash involvement typically are attributed to biological and developmental risk-taking associated with young age. However, young drivers differ from older ones along several sociodemographic dimensions, including higher poverty rates and greater concentration in poorer areas, which may contribute to their risks.

Method

Using Fatality Analysis Reporting System, Census, and Federal Highway Administration data for 1994-2007, bivariate and multivariate regression analyses were conducted of fatal motor-vehicle crash involvements per 100 million miles driven by driver age (16 through 74) and state along with 14 driver-, vehicle-, and state-level variables.

Results

Driver age was not a significant predictor of fatal crash risk once several factors associated with high poverty status (more occupants per vehicle, smaller vehicle size, older vehicle age, lower state per-capita income, lower state population density, more motor-vehicle driving, and lower education levels) were controlled. These risk factors were significantly associated with each other and with higher crash involvement among adult drivers as well.

Summary and Discussion

The strong association between fatal crash risk and environments of poverty as operationalized by substandard vehicle and driving conditions suggests a major overlooked traffic safety factor particularly affecting young drivers.