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931.
Nicole Corsten-Janssen Katelijne Bouman Janouk C. D. Diphoorn Arjen J. Scheper Rianne Kinds Julia el Mecky Hanna Breet Joke B. G. M. Verheij Ron Suijkerbuijk Leonie K. Duin Gwendolyn T. R. Manten Irene M. van Langen Rolf H. Sijmons Birgit Sikkema-Raddatz Helga Westers Cleo C. van Diemen 《黑龙江环境通报》2020,40(10):1300-1309
Objective
Conventional genetic tests (quantitative fluorescent-PCR [QF-PCR] and single nucleotide polymorphism-array) only diagnose ~40% of fetuses showing ultrasound abnormalities. Rapid exome sequencing (rES) may improve this diagnostic yield, but includes challenges such as uncertainties in fetal phenotyping, variant interpretation, incidental unsolicited findings, and rapid turnaround times. In this study, we implemented rES in prenatal care to increase diagnostic yield.Methods
We prospectively studied 55 fetuses. Inclusion criteria were: (a) two or more independent major fetal anomalies, (b) hydrops fetalis or bilateral renal cysts alone, or (c) one major fetal anomaly and a first-degree relative with the same anomaly. In addition to conventional genetic tests, we performed trio rES analysis using a custom virtual gene panel of ~3850 Online Mendelian Inheritance in Man (OMIM) genes.Results
We established a genetic rES-based diagnosis in 8 out of 23 fetuses (35%) without QF-PCR or array abnormalities. Diagnoses included MIRAGE (SAMD9), Zellweger (PEX1), Walker-Warburg (POMGNT1), Noonan (PTNP11), Kabuki (KMT2D), and CHARGE (CHD7) syndrome and two cases of Osteogenesis Imperfecta type 2 (COL1A1). In six cases, rES diagnosis aided perinatal management. The median turnaround time was 14 (range 8-20) days.Conclusion
Implementing rES as a routine test in the prenatal setting is challenging but technically feasible, with a promising diagnostic yield and significant clinical relevance. 相似文献932.
This study describes the development of the Perceived Restorative Characteristics Questionnaire (PRCQ), a measure of perceived restorative characteristics of zoo attractions. The questionnaire was administered in two zoo attractions. The hypothesized five factor structure of the PRCQ, and relations between perceived restorative characteristics and experienced pleasure in and preference for the attractions were examined. In Study 1, 137 visitors of a Dutch zoo evaluated perceived restorative characteristics of a butterfly garden; In Study 2, 158 visitors evaluated those of a baboon attraction. In Study 1 three factors emerged (fascination, escape and coherence); In Study 2 four factors could be distinguished (fascination, novelty, escape, coherence). Compatibility did not appear as a separate factoring either study. Perceived fascination and escape were significant predictors of experienced pleasure and preference in both attractions. The implications of the findings are discussed. 相似文献
933.
Meine van Noordwijk Fahmuddin Agus Sonya Dewi Herry Purnomo 《Mitigation and Adaptation Strategies for Global Change》2014,19(6):677-692
Land-based emissions of carbon dioxide derive from the interface of forest and agriculture. Emission estimates require harmonization across forest and non-forest data sources. Furthermore, emission reduction requires understanding of the linked causes and policy levers between agriculture and forestry. The institutional forestry traditions dominated the emergence of the discourse on Reducing Emissions from Deforestation and forest Degradation (REDD+) while more holistic perspectives on land-based emissions, including agriculture, found a home in international recognition for Nationally Appropriate Mitigation Actions (NAMAs). We tested the hypothesis that, at least for Indonesia, the NAMA framework provides opportunities to resolve issues that REDD+ alone cannot address. We reviewed progress on five major challenges identified in 2007 by the Indonesian Forest Climate Alliance: 1) scope and ‘forest’ definition; 2) ownership and tenurial rights; 3) multiplicity and interconnectedness of drivers; 4) peatland issues across forest and non-forest land categories; and 5) fairness and efficiency of benefit-distribution mechanisms across conservation, degradation and restoration phases of tree-cover transition. Results indicate that the two policy instruments developed in parallel with competition rather than synergy. Three of the REDD+ challenges can be resolved by treating REDD+ as a subset of the NAMA and national emission reduction plans for Indonesia. We conclude that two issues, rights and benefit distribution, remain a major challenge, and require progress on a motivational pyramid of policy and polycentric governance. National interest in retaining global palm oil exports gained priority over expectations of REDD forest rents. Genuine concerns over climate change motivate a small but influential part of the ongoing debate. 相似文献
934.
935.
936.
Bregje K. van Wesenbeeck Wiebe de Boer Siddharth Narayan Wouter R. L. van der Star Mindert B. de Vries 《Mitigation and Adaptation Strategies for Global Change》2017,22(7):1087-1094
Adaptation planning for flood risk forms a significant part of global climate change response. Engineering responses to higher water levels can be prohibitively costly. Several recent studies emphasize the potential role of ecosystems in flood protection as adaptive risk reduction measures while also contributing to carbon fixation. Here, we use a conceptual model study to illustrate the built-in adaptive capability of ecosystems to reduce a wide range of wave heights, occurring at different water levels, to a narrower range. Our model shows that wave height of waves running through a forested section is independent of initial height or of water level. Although the underlying phenomenon of non-linear wave attenuation within coastal vegetation is well studied, implications of reducing variability in wave heights for design of ecosystem and levee combinations have not yet been properly outlined. Narrowing the range of wave heights by a vegetation field generates an adaptive levee that is robust to a whole range of external conditions rather than only to a maximum wave height. This feature can substantially reduce costs for retrofitting of levees under changing future wave climates. Thereby, in wave prone areas, inclusion of ecosystems into flood defense schemes constitutes an adaptive and safe alternative to only hard engineered flood risk measures. 相似文献
937.
Tom van der Voorn Jaco Quist Claudia Pahl-Wostl Marjolijn Haasnoot 《Mitigation and Adaptation Strategies for Global Change》2017,22(3):519-546
The paper reports on a comparative study of three different cases on vision and strategy development for climate change adaptation planning in (i) The South African Breede–Overberg Catchment, (ii) The Mississippi Estuary-New Orleans region and (iii) The Dutch Rhine-Meuse Estuary. The objective of the paper is twofold: to develop a better understanding of such processes and to further develop the Backcasting-Adaptive Management (BCAM) methodology. A framework for case evaluation is developed using six dimensions: (i) inputs and resources, (ii) future vision, (iii) stakeholder engagement, (iv) methodological aspects, (v) pathway development and (vi) impact. Major conclusions based on a cross-case comparison and testing propositions are (i) participatory vision development is a strong tool for climate change adaptation planning in different governance contexts and shows considerable diversity in its application in these contexts; (ii) a single, shared future vision is not a prerequisite for vision and pathway development and endorsement; (iii) broad stakeholder engagement enriches strategy development, but the involvement of marginal groups requires additional efforts and capacity building; (iv) multiple pathways and robust elements are useful but require novel expertise; and (v) more institutional embeddedness and support for participatory processes lead to better implementation of the outcomes of these processes. 相似文献
938.
Henk F. van der Molen Koos A.H. Zwinderman Judith K. Sluiter Monique H.W. Frings-Dresen 《Safety Science》2011,49(8-9):1180-1186
ObjectivesThis study compares the effectiveness of two types of interventions with no intervention on the prevention of needle stick injuries (NSIs).MethodsHealth care workers, who were at risk for NSIs, were eligible for this three-armed cluster randomized controlled trial. In total, 23 hospital wards were randomly assigned to 1 of 2 intervention groups, which were given either a needle safety device and a workshop (NW; 7 wards, n = 267) or a workshop only (W; 8 wards, n = 263), or to a control group (C; 8 wards, n = 266). The primary outcome was the half-year incidence of NSIs, which was measured through questionnaires and official notification at the occupational health service at baseline (T0), 6 months (T1) and 12 months (T2) after baseline. Analysis were done by intention to treat. This study is registered as a prospective randomized trial, number NTR1207.ResultsA statistically significant difference was found between the groups for the half-year incidence of NSIs (p = 0.046) on the basis of questionnaire data with ORs for reported NSIs for the NW group compared with the control group of 0.34 (95% CI: 0.13–0.91) and 0.45 (95% CI: 0.19–1.06) for the W group compared with the control group. The officially registered NSIs during the study period showed no statistical differences between the groups.ConclusionsThe combined intervention of the introduction of needle safety devices and an interactive workshop led to the highest reduction in the number of self-reported NSIs compared to a workshop alone or no intervention. 相似文献
939.
van der Salm C Dupas R Grant R Heckrath G lversen BV Kronvang B Levi C Rubaek G Schoumans OF 《Journal of environmental quality》2011,40(5):1617-1626
To reduce losses from agricultural soils to surface water, mitigation options have to be implemented as a local scale. For a cost-effective implementation of these measures, an instrument to identify critical areas for P leaching is indispensable. In many countries, P-index methods are used to identify areas as risk for P losses to surface water. In flat areas, where losses by leaching are dominant, these methods have their limitations because leaching is often not described in detail, PLEASE, is a simple mechanistic model designed to stimulate P Losses by leaching at the field scale using a limited amount of local field data. In this study, PLEASE, was applied to 17 lowland sites in Denmark and 14 lowland sites in the Netherlands. Results show that the simple model simulated measured fluxes and concentrations in water from pipe drains, suction cups, and groundwater quite well. The modeling efficiency ranged from 0.92 for modeling total-P fluxes to 0.36 fr modeling concentrations in groundwater. Poor results were obtained for heavy clay soils and eutrophic peat soils, where fluxes and concentration were strongly underestimated by the model. The poot performance for the heavy clay soil can be explained by the transport of P through macropores to the drain pipes and the underestimation of overland flow on this heavy-textured soil. In the eutrophic peat soils, fluxes were underestimated due to the release of P from deep soil layers. 相似文献
940.
Soil organic matter (SOM) is essential for sustaining food production and maintaining ecosystem services and is a vital resource base for storing C and N. The impact of long-term use of synthetic fertilizer N on SOM, however, has been questioned recently. Here we tested the hypothesis that long-term application of N results in a decrease in SOM. We used data from 135 studies of 114 long-term experiments located at 100 sites throughout the world over time scales of decades under a range of land-management and climate regimes to quantify changes in soil organic carbon (SOC) and soil organic nitrogen (SON). Published data of a total of 917 and 580 observations for SOC and SON, respectively, from control (unfertilized or zero N) and N-fertilized treatments (synthetic, organic, and combination) were analyzed using the SAS mixed model and by meta-analysis. Results demonstrate declines of 7 to 16% in SOC and 7 to 11% in SON with no N amendments. In soils receiving synthetic fertilizer N, the rate of SOM loss decreased. The time-fertilizer response ratio, which is based on changes in the paired comparisons, showed average increases of 8 and 12% for SOC and SON, respectively, following the application of synthetic fertilizer N. Addition of organic matter (i.e., manure) increased SOM, on average, by 37%. When cropping systems fluctuated between flooding and drying, SOM decreased more than in continuous dryland or flooded systems. Flooded rice ( L.) soils show net accumulations of SOC and SON. This work shows a general decline in SOM for all long-term sites, with and without synthetic fertilizer N. However, our analysis also demonstrates that in addition to its role in improving crop productivity, synthetic fertilizer N significantly reduces the rate at which SOM is declining in agricultural soils, worldwide. 相似文献