Ozonation of a mixture of estrogens and progestins in aqueous solution: Interpretation of experimental results by computational methods

In this paper the results of a thorough evaluation of the environmental fate and effects of azilsartan are presented. Azilsartan medoxomil is administered as a pro-drug for the treatment of patients with essential hypertension. The pro-drug is converted by hydrolysis to the active pharmaceutical ingredient azilsartan. Laboratory tests to evaluate the environmental fate and effects of azilsartan medoxomil were conducted with azilsartan and performed in accordance with OECD test guidelines. The predicted environmental concentration (PEC) in surface water was estimated at 0.32 μg L⁻¹ (above the action limit of 0.01 μg L⁻¹), triggering a Phase II assessment. Azilsartan is not readily biodegradable. Results of the water sediment study demonstrated significant shifting of azilsartan metabolites to sediment. Based on the equilibrium partitioning method, metabolites are unlikely to pose a risk to sediment-dwelling organisms. Ratios of the predicted environmental concentrations (PECs) to the predicted-no-effect concentrations (PNECs) did not exceed the relevant triggers, and the risk to aquatic, sewage treatment plant (STP), groundwater and sediment compartments was concluded acceptable. A terrestrial assessment was not triggered. Azilsartan poses an acceptable risk to the environment.     

Oil spill studies: A review of ecological effects

We reviewed seven particularly well known and/or studied oil spills that have occurred since the National Academy of Sciences 1975 report, Petroleum in the Marine Environment or that occurred prior to that report but about which significant new information has since been acquired. The spills studied were from the bargeFlorida, and tankersArrow, Argo Merchant, Amoco Cadiz, andTsesis and blowouts from the Bravo and Ixtoc I platforms.These best studies yield only limited insight into effects because they lack controls and have a high degree of natural variability. TheTsesis, Florida, andAmoco Cadiz cases are exceptional since they occurred in areas of ongoing research programs and had nearby areas suitable for controls. Oil spills have produced measurable effects on ecosystems that have not been readily predictable from laboratory studies on isolated organisms. However, ecosystemlevel interactions are poorly understood even without the complications resulting from effects of pollution. These generalizations emerge: oil regularly reaches sediments after a spill; oil in anoxic sediments is persistent; oil regularly contaminates Zooplankton and benthic invertebrates; fish are also contaminated, but to a lesser extent; oil contamination decreases the abundance and diversity of benthic communities.     

Predicting Root Density in Streambanks1

Abstract: Roots of riparian vegetation increase streambank erosion resistance and structural stability; therefore, knowledge of root density and distribution in streambanks is useful for stream management and restoration. The objective of this study was to compare streambank root distributions for herbaceous and woody vegetation and to develop empirical models to predict root density. Root length density, root volume ratio, soil physical and chemical properties, and above‐ground vegetation densities were measured at 25 sites on six streams in southwestern Virginia. The Mann‐Whitney test was used to determine differences in root density along stream segments dominated by either woody or herbaceous vegetation. Multiple linear regression was used to develop relationships between root density and site characteristics. Study results showed that roots were evenly distributed across the bank face with the majority of roots having diameters less than 2 mm. Soil bulk density and above‐ground vegetation were key factors influencing root density. While significant relationships were developed to predict root density, the predictive capabilities of the equations was low. Because of the highly variable nature of soil and vegetation properties, it is recommended at this time that soil erodibility and root density be measured in the field for design and modeling purposes, rather than estimated based on empirical relationships.     

One year in the life of <Emphasis Type="Italic">Bufo punctatus</Emphasis>: annual patterns of body temperature in a free-ranging desert anuran

The Mojave Desert is characterized by hot dry summers and cold winters. The red-spotted toad (Bufo (Anaxyrus) punctatus) is the predominant anuran species; yet little is known of their thermal histories and strategies to avoid temperature extremes. We measured body temperature (T(b)) in free-ranging adult toads across all four seasons of a year using implanted data loggers. There is marked individual variation in the temperatures experienced by these toads. As expected, toads generally escape extreme seasonal and diel temperature fluctuations. However, our data demonstrate a much wider estimated T(b) range than was previously assumed. Though often for short periods, red-spotted toads do experience T(b) as low as 3.1 degrees C and as high as 39.1 degrees C. All animals showed periods of prolonged thermal stability in cooler months and wider diel oscillations in warmer months. Red-spotted toad thermal history is likely a function of site choice; the exploitation of different refuges results in diverse thermal experiences. These data represent the most complete record of thermal experiences for a desert anuran and reveal greater extremes in body temperature than previously suggested.     

美国1961～2000年氮使用量的变化及未来趋势预测

从1961～1997年,因人类活动而输入到美国的氮翻了一番,特别是在上个世纪60年代和70年代,其增长量最大.尽管无机氮肥的使用量增长最大,但矿物燃料燃烧所造成的NOx排放,也有明显的增加.1961年,美国农业生产系统中的生物固氮量是活性氮的最大来源;到了1997年,尽管生物固氮量也有增加,但相比而言,无机氮肥的使用和NOx的排放增加得更快,成为两个最大的氮源.1961～1997年,在输入到美国的活性氯中,有2/3发生了脱氮反应或者是被贮存在土壤与生物群落之中,有1/3输出到境外.在输出到境外的这部分氮中,通过河流流到海洋中的分量最大,其次是通过粮食和饲料出口而到其它国家以及通过大气平流传输到了海洋中.动物性蛋白的消费是美国农业系统中氮使用的主要驱动因子,如果饮食方式或农业生产方式不发生改变,在未来30年的时间里,美国肥料的使用量将继续增长,流向海洋中的氮通量将可能再增长30%,但也有可能出现下降.     

The Control of Biological Invasions in the World's Oceans

Abstract: The introduction of alien, or nonindigenous, animals and plants has been identified by scientists and policy makers as a major threat to biodiversity in marine ecosystems. Although government agencies have struggled to control alien species on land and freshwater for decades with mixed success, the control of alien marine species is in its infancy. Prevention of introduction and establishment must be the first priority, but many populations of alien marine species are already well established worldwide. National and international policies leave loopholes for additional invasions to occur and provide only general guidance on how to control alien species once they are established. To address this issue, a multinational group of 25 scientists and attorneys convened in 1998 to examine options for controlling established populations of alien marine species. The discussions resulted in a framework for control of alien marine species to provide decision-making guidance to policymakers, managers, scientists, and other stakeholders. The framework consists of seven basic steps: (1) establish the nature and magnitude of the problem, (2) set objectives, (3) consider the full range of alternatives, (4) determine risk, (5) reduce risk, (6) assess benefits versus risks, and ( 7) monitor the situation. This framework can provide guidance for control efforts under the existing patchwork of national laws and can help provide a foundation for international cooperation.     

Nitrogen use in the United States from 1961-2000 and potential future trends

Nitrogen inputs to the US from human activity doubled between 1961 and 1997, with most of the increase in the 1960s and 1970s. The largest increase was in use of inorganic N fertilizer, but emissions of NOx from fossil-fuel combustion also increased substantially. In 1961, N fixation in agricultural systems was the largest single source of reactive N in the US. By 1997, even though N fixation had increased, fertilizer use and NOx emissions had increased more rapidly and were both larger inputs. In both 1961 and 1997, two thirds of reactive N inputs were denitrified or stored in soils and biota, while one third was exported. The largest export was in riverine flux to coastal oceans, followed by export in food and feeds, and atmospheric advection to the oceans. The consumption of meat protein is a major driver behind N use in agriculture in the US Without change in diet or agricultural practices, fertilizer use will increase over next 30 years, and fluxes to coastal oceans may increase by another 30%. However, substantial reductions are possible.