Bisphenol A (BPA) is a chemical with high production volume and wide applications in many industries. Although BPA is known
as an endocrine disruptor, its toxic mechanisms have not been fully characterized. Due to its structural similarity to thyroid hormones
thyroxine (T4) and triiodothyronine (T3), one possible mechanism of BPA toxicity is disruption of hormone transport by competitive
binding with the transport proteins. In this study, the binding interactions of BPA, T4, and T3 with three thyroid hormone transport
proteins, human serum albumin (HSA), transthyretin (TTR), and thyroxine-binding globulin (TBG) were investigated by fluorescence
measurement. Using two site-specific fluorescence probes dansylamide and dansyl-L-proline, the binding constants of BPA with HSA
at drug site I and site II were determined as 2.90 104 and 3.14 104 L/mol, respectively. By monitoring the intrinsic fluorescence
of tryptophan, a binding constant of 4.70 103 L/mol was obtained. Similarly, by employing 8-anilino-1-naphthalenesulfonic acid as
fluorescence probe, the binding a nity of BPA with TTR and TBG was measured to be 3.10 105 and 5.90 105 L/mol, respectively.
In general, BPA showed lower binding a nity with the proteins than T3 did, and even lower a nity than T4. Using these binding
constants, the amount of BPA which would bind to the transport proteins in human plasma was estimated. These results suggest that
the concentrations of BPA commonly found in human plasma are probably not high enough to interfere with T4 transport. 相似文献
Sulfamethoxazole (SMX) is one of the most common detected antibiotics in the environment. In order to study whether SMX can
a ect behavior and growth and whether these e ects could be transferred to the progeny, Caenorhabditis elegans was exposed at
environmentally relevant concentrations for 24, 48, 72 and 96 hr, respectively. After exposure, the exposed parent generation (P0)
was measured for behavior and growth indicators, which were presented as percentage of controls (POC). Then their corresponding
unexposed progeny (F1) was separated and measured for the same indicators. The lowest POC for P0 after 96 hr-exposure at 100
mg/L were 37.8%, 12.7%, 45.8% and 70.1% for body bending frequency (BBF), reversal movement (RM), Omega turns (OT) and
body length (BL), respectively. And F1 su ered defects with the lowest POC as 55.8%, 24.1%, 48.5% and 60.7% for BBF, RM, OT
and BL, respectively. Defects in both P0 and F1 showed a time- and concentration-dependent fashion and behavior indicators showed
better sensitivity than growth indicator. The observed e ects on F1 demonstrated the transferable properties of SMX. Defects of SMX
at environmental concentrations suggested that it is necessary to perform further systematical studies on its ecological risk in actual
conditions. 相似文献
Environmental Chemistry Letters - During the Corona Virus Disease 2019 (COVID-19) pandemic, protective equipment, such as masks, gloves and shields, has become mandatory to prevent person-to-person... 相似文献
In this work, a series of novel proton-gradient-transfer acid complexes (PGTACs) were developed. Their physicochemical properties, including thermal stability, melting point, and Hammett acidity, were measured. The effects of catalyst loading, reaction temperature, and substrate expansion on the catalytic performance were systematically studied. It is found that the combination of bidentate N-heterocycle and H2SO4 (1:2 M ratio) could form simultaneously N–H covalent bond and N…H hydrogen bond, which makes the PGTACs excellent catalysts integrate the advantages of strong acids (high catalytic activity) and ionic liquids (phase separation) in the esterification reaction. Moreover, these PGTACs can be reused by convenient phase separation without obvious diminution of catalytic activity. It is concluded that these PGTACs are potential alternative candidates for esterification reaction in the process of industrial catalysis. 相似文献
Local governments are the dominant players in haze pollution control; furthermore, financial power reconstruction affects the effectiveness of haze control. Government innovation preference achieves win-win results for environmental protection and economic development by increasing innovation support. Therefore, a moderating variable for government innovation preference was added to the fiscal decentralization effect on haze pollution, and their interactive effect on haze pollution was studied. This study was conducted in 30 provincial regions. Thus, the severity of regional haze pollution differs because of temporal heterogeneity and asynchronous development. Furthermore, we analyzed the impact on haze pollution from the perspectives of the temporal and spatial differences in different regions of China. The results indicate that (1) fiscal decentralization increases haze pollution, while government innovation preferences control it. (2) In a local evaluation model with a diversified background, fiscal decentralization restrains haze pollution, and pollution source complexity reduces government innovation preference’s control pollution function. The interaction term revealed that government innovation preferences had a significant moderating effect. (3) Fiscal decentralization and government innovation preferences control the heterogeneity of haze pollution in different regions.