The aim of this study was to assess the acute health effects of individual ozone (O3) exposure on the respiratory system in the elderly. A total of 40 non-smoking elderly volunteers completed personal 24 h of measurement for O3 and fine particulate matter (PM2.5). To assess health effects, we measured the pulmonary function and five inflammatory biomarkers in exhaled breath condensate (EBC), including interleukin-2 (IL-2), interferon-γ (IFN-γ), prostaglandin E2 (PGE2), and tumor necrosis factor α/β (TNFα/β). We used the generalized additive model to analyze the association between O3 and these health effects, after adjusting PM2.5, BMI, and sex as confounders. As a result, we found a negative correlation between O3 and forced vital capacity (FVC) or forced expiratory volume-one second (FEV1). With the increasing of O3 by 10 μg/m3, FVC and FEV1 decreased by 0.13 L (95% CI 0.01, 0.26) and 0.11 L (95% CI 0.02, 0.20), respectively. We found no statistical significance between O3 and biomarkers in EBC. The results suggested that individual 24-h O3 exposure was associated with decreased pulmonary function in the elderly.
The impacts of production disruption in Remanufacturing/Manufacturing (R/M) integrated supply chain on the sales and the methods of production disruption management were studied. A system dynamics model for the R/M integrated supply chain with production disruption was improved by system dynamics methodology. The numerical examples were shown to illustrate the simulation results. The impacts of different recovery times of production disruption on the sales were presented. In order to mitigate the disruption risks and ensure the sales at the needed sales ratio, the methods for setting multi-echelon inventory levels before the occurring of the production disruption and the methods for making back-up plans after the production disruption occurs were given. 相似文献
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