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731.
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Ping Gong Niladri Basu Anton M. Scheuhammer Edward J. Perkins 《Environmental science and pollution research international》2010,17(1):181-186
Background, aim, and scope
Hexanitrohexaazaisowurtzitane (CL-20) is a relatively new energetic compound sharing some degree of structural similarity with hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), a known neurotoxic compound. Previously, we demonstrated using a noninvasive electrophysiological technique that CL-20 was a more potent neurotoxicant than RDX to the earthworm Eisenia fetida. In the present study, we investigated the effect of CL-20 exposure and subsequent recovery on muscarinic acetylcholine receptors (mAChRs) to further define the mechanism of reversible neurotoxicity of CL-20 in E. fetida.Materials and methods
We used a noninvasive electrophysiological technique to evaluate neurotoxicity in CL-20-treated worms, and then measured how such exposures altered levels of whole-body mAChR in the same animals.Results and discussion
A good correlation exists between these two types of endpoints. Effect on mAChR levels was most prominent at day 6 of exposure. After 7 days of recovery, both conduction velocity and mAChR were significantly restored. Our results show that sublethal concentrations of CL-20 significantly reduced mAChR levels in a concentration- and duration-dependent manner, which was accompanied with significant decreases in the conduction velocity of the medial and lateral giant nerve fibers. After 7-day post exposure recovery, worms restored both neurochemical (mAChR) and neurophysiological (conduction velocity) endpoints that were reduced during 6-day exposures to CL-20 concentrations from 0.02 to 0.22 µg/cm2.Conclusions and perspectives
Our findings support the idea that CL-20 induced neurotoxic effects are reversible, and suggest that CL-20 neurotoxicity may be mediated through the cholinergic system. Future studies will investigate other neurotransmission systems such as GABA, glutamate, and monoamine. Ion channels in the nerve membrane should be examined to further define the precise mechanisms underlying CL-20 neurotoxicity. 相似文献733.
提出了一种新的绿矾综合利用的途径,即绿矾经碳酸盐转化,然后采用无烟煤作还原剂,CaCO3为添加剂,进行高温还原焙烧制取还原铁粉.先将绿矾用水溶解,用理论量1.2倍的(NH4)2CO3将FeSO4转化为FeCO3,FeCO3焙烧的最佳条件是FeCO3∶无烟煤∶CaCO3为100∶60∶8,焙烧温度为1000℃,焙烧时间为4.5 h.粗还原铁粉化学成分除C含量较高外,符合国家有关标准,900℃左右经氢气精还原1 h所得精还原铁粉化学成分的各项指标,均达到或优于国家有关标准的要求. 相似文献
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Yang L Xiaoye Z Sunling G Huizheng C Dan W Wenjun Q Junying S 《Environmental monitoring and assessment》2006,120(1-3):301-312
The concentrations of EC, BC and dust aerosols were determined for atmospheric samples collected from an observation station in Xi'an, China. The results show that the averaged correlation coefficient between EC and BC was founded to be 0.72 with 0.81 (n = 49) in autumn, 0.70 (n = 112) in winter and 0.69 (n = 57) in spring, respectively. Absorption coefficients of dust aerosol were estimated to be 2.7 m2 g−1 in autumn and 4.4 m2 g−1 in winter. The comparison of absorption coefficients of dust aerosol with those of BC implies that BC is the principal light-absorbing aerosol over Xi'an atmosphere. By combining thermal analysis of elemental carbon and dust contents in the aerosol samples, however, the fraction of dust absorption to total light absorption is estimated to be 19% in autumn and 31% in winter, respectively. 相似文献
737.
可再生能源储存系统是利用钢筋混凝土桩基础来储存由太阳能板产生的可再生能源,可再生能源以压缩空气的形式储存在空心截面的桩基内,桩基础作为上部结构的承载结构,不仅要承受上部结构荷载,还要承受土体的反作用力和压缩空气的压力。然而,混凝土在拉应力作用下易产生裂缝,导致钢筋混凝土桩储存能源的使用性能和耐久性受限。为了克服传统钢筋混凝土能量桩的这些缺陷,针对各种FRP(Fiber Reinforced Polymer)-混凝土复合桩基础储能和承载的双功能进行研究。综合考虑结构荷载、土体的反作用和压缩空气热动力循环引起的内部空气压力的共同作用,对多种形式的复合能量桩基础体系的适用性进行了综合有限元分析。研究表明,内侧和外侧的FRP管可以有效提高使用性能和耐久性,相对于钢筋混凝土桩,FRPC管桩的使用可靠性和耐久性性能更高。 相似文献
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Lu Hao Wang Shengsheng Li Yun Gong Hui Han Jingyi Wu Zuliang Yao Shuiliang Zhang Xuming Tang Xiujuan Jiang Boqiong 《Environmental science and pollution research international》2017,24(19):16195-16205
Environmental Science and Pollution Research - To reveal the seasonal variations and sources of PM2.5-bound polycyclic aromatic hydrocarbons (PAHs) during haze and non-haze episodes, daily PM2.5... 相似文献