Causes of respiratory failure in COVID-19 patients

Environmental Science and Pollution Research -     

COVID-19: a new emerging respiratory disease from the neurological perspective

Environmental Science and Pollution Research - Coronavirus disease 2019 (COVID-19) has become a challenging public health catastrophe worldwide. The newly emerged disease spread in almost all...     

The link among microbiota,epigenetics, and disease development

Environmental Science and Pollution Research - The microbiome is a community of various microorganisms that inhabit or live on the skin of humans/animals, sharing the body space with their hosts....     

Effects of increasing temperatures on biomarker responses and accumulation of hazardous substances in rope mussels (Mytilus galloprovincialis) from Bizerte lagoon

This study examined the influence of increasing temperatures in spring and summer on biochemical biomarkers in Mytilus galloprovincialis mussels sampled from Bizerte lagoon (northern Tunisia). Spatial and seasonal variations in a battery of seven biomarkers were analyzed in relation to environmental parameters (temperature, salinity, and pH), physiological status (condition and gonad indexes), stress on stress (SoS), and chemical contaminant levels (heavy metals, polycyclic aromatic hydrocarbons (PAHs), and PCBs) in digestive glands. Integrated biological response (IBR) was calculated using seven biomarkers (acetylcholinesterase (AChE), benzo[a]pyrene hydroxylase (BPH), multixenobiotic resistance (MXR), glutathione S-transferase (GST), catalase (CAT), malondialdehyde (MDA), and metallothioneins (MT). Seasonal variations in biological response were determined during a critical period between spring and summer at two sites, where chemical contamination varies by a factor of 2 for heavy metals and a factor 2.5 for PAHs. The analysis of a battery of biomarkers was combined with the measurement of physiological parameters at both sites, in order to quantify a maximum range of metabolic regulation with a temperature increase of 11 °C between May and August. According to our results, the MT, MDA, CAT, and AChE biomarkers showed the highest amplitude during the 11 °C rise, while the BPH, GST, and MXR biomarkers showed the lowest amplitude. Metabolic amplitude measured with the IBR at Menzel Abdelrahmen—the most severely contaminated station—revealed the highest metabolic stress in Bizerte lagoon in August, when temperatures were highest 29.1 °C. This high metabolic rate was quantified for each biomarker in the North African lagoon area and confirmed in August, when the highest IBR index values were obtained at the least contaminated site 2 (IBR = 9.6) and the most contaminated site 1 (IBR = 19.6). The combined effects of chemical contamination and increased salinity and temperatures in summer appear to induce a highest metabolic adaptation response and can therefore be used to determine thresholds of effectiveness and facilitate the interpretation of monitoring biomarkers. This approach, applied during substantial temperature increases at two sites with differing chemical contamination, is a first step toward determining an environmental assessment criteria (EAC) threshold in a North African lagoon.     

Uranium isotopes in groundwater from the “Jeffara coastal aquifer” (southeastern Tunisia)

The distributions of ²³⁸U and ²³⁴U in groundwater from the “Jeffara aquifer” were studied by using alpha spectrometric methods. The concentration ranges of ²³⁸U and ²³⁴U/²³⁸U activity ratios were 1.34 ± 0.17 to 3.43 ± 0.38 ppb, and 1.43 ± 0.23 to 1.82 ± 0.27 respectively. Variations in concentrations can be related not only to lithostratigraphic formations but also to different origins of groundwater. U content of Jeffara are found very similar to those of Continental Intercalaire aquifer in both El Hamma and Chenchou regions, indicating that the Continental Intercalaire is the dominant source of the groundwater.     

Coronaviruses in humans and animals: the role of bats in viral evolution

Environmental Science and Pollution Research - Bats act as a natural reservoir for many viruses, including coronaviruses, and have played a crucial epidemiological role in the emergence of many...     

Radiant Domestic Combustion Stove System: Experimental and Simulated Study of Energy Use and Thermal Comfort

A steady-state space radiant heat model and a stove combustion model are developed to simulate the heat exchanges between various surfaces in the room and the stove and stack surfaces, assuming stiochiometric combustion inside the stove and the exhaust gases flow out through the stack by natural convection. The space heat model calculates the fuel consumption, the stove, stack temperatures, and the mass flow rate of exhaust gases, and provides an opportunity to study the energy efficiency of the stove, while satisfying the constraints of thermal comfort. Fanger (1982) Fanger, P. O. 1982. Thermal Comfort Analysis and Applications in Engineering, 156–198. New York: McGraw Hill.  [Google Scholar] model and a radiation exchange model between various surfaces of the space, the thermal building energy balance, and stove combustion process is applied to determine the mean radiant temperature (MRT) and the extent of thermal comfort as determined by predicted mean vote (PMV).

The overall model is validated by performing experiments in a room placed inside a controlled outdoor environment. The room is heated using a domestic stove common for rural areas of Lebanon and the MRT, the room air temperature, the walls and window temperatures are measured at two stove positions. The measured MRT, the average room temperature, and the wall surface temperatures agreed within ±7% of values predicted by the numerical model.

A parametric study is performed to optimize the stove and occupant locations in the room where adequate comfort level can be maintained at lower fuel consumption levels. The values of MRT and PMV depend strongly on the position of the radiant stove heater and stack with respect to the cold window and the occupant location. It is shown that it is possible to save up to 15% in stove fuel consumption by changing the stove position in the room with respect to the window and to the person, while maintaining the same level of comfort.     

Adsorption models of Cs radionuclide and Sr (II) on some Egyptian soils

Distribution of cesium (¹³⁴Cs and ¹³⁷Cs) and strontium (Sr-II) between soil/water phases depends on many factors such as concentration of these ions between phases, the cation exchange capacity (CEC) of the soil as well as its clay content, chemical composition (especially Na, K, Ca, and Mg ions), grain size distribution, calcite, iron oxide content, and organic coatings. Distribution coefficients (Kd) of cesium (labeled with ¹³⁷Cs) and strontium were measured on the grain size distributions ≥32 μm of four soil samples. These soils were obtained from four different locations within Inshas site in Egypt and three groundwater samples were obtained from the same site locations. X-ray diffraction showed that the soil samples consisted mainly of quartz mixed with the minor amounts of kaolonite and clay minerals. Sorption experiments were carried out at strontium aqueous concentrations range 10⁻⁷ to 10⁻⁴ mol l⁻¹. The CEC and Kds for cesium and strontium were measured at the same metal concentrations range. Distribution coefficients of cesium were found to be influenced by the composition of the soil, while the distribution coefficients of strontium were found to depend on calcium concentrations in the soil/groundwater system. The aim of this study was to determine the safety assessment of disposal ¹³⁷Cs radionuclide and Sr(II) in the aquifer regions inside the Inshas site. Sequential extraction tests showed that, strontium was associated with the carbonate fractions and majority of cesium was sorbed on the iron oxides and the residue.     

Climatic changes and their role in emergence and re-emergence of diseases

Environmental Science and Pollution Research - Global warming and the associated climate changes are predictable. They are enhanced by burning of fossil fuels and the emission of huge amounts of...     

Impact of chlorpyrifos on cerebrum and cerebellum maturity in suckling rats

The purpose of our study is to assess the effect of chlorpyrifos (CPF) on rat cerebral and cerebellar maturity during the suckling period. Female Wistar rats were given 0.2?g?L^?1 of CPF in drinking water, equivalent to 40?mg?kg^?1 of body weight?day^?1, from day zero until day ten after delivery. In treated pups, plasma butyrylcholinesterase (BuChE) activity was inhibited by 70%. Cerebrum and cerebellum acetyl-cholinesterase (AchE) activities were reduced by 71 and 75%, respectively. The results suggest that CPF was distributed in pup tissues through the milk of lactating mothers, resulting in inhibition of AchE activities. At age 10 days, the CPF-treated pups showed a 28% decrease in body weight, a 23 and 41% decrease in plasma free T₃ and T₄ levels and reduction in cerebral and cerebellar protein content by 36 and 38%, respectively. Consistent histological changes were found in the cerebellum of CPF treated pups, with the external granular layer being markedly developed, the Purkinje cell bodies being poorly differentiated and abnormally distributed into the internal granular layer.