Outcome of cases of de novo structural rearrangements diagnosed at amniocentesis

The frequency of de novo rearrangements at amniocentesis was determined in 76952 prenatal diagnoses from centres in the United States. Rates for balanced rearrangements are slightly greater than rates previously reported in the newborn, possibly because banding studies were not used in the latter. Rates for unbalanced rearrangements are considerably higher in the amniocentesis data not only because banding was used but also because a substantial loss of abnormal conceptions is to be expected between amniocentesis and birth. The higher frequency of cases with supernumerary markers at amniocentesis is unexplained. A review of 66 apparently balanced de novo rearrangements found at amniocentesis revealed evidence of abnormality in five; in four of these the abnormality was noted in the abortus. The number of cases observed is still too small to rule out a risk of abnormality no greater than the usual rate of abnormalities at birth. Abnormalities were detected in 6 of 10 cases with unbalanced de novo rearrangements. In 33 cases of non-familial supernumerary chromosomes 6 (18.2 per cent) showed abnormality. Non-satellited markers appeared to have a higher rate of abnormality than satellited markers but the difference is not statistically significant. Further studies and improved follow-up of de NOVO cases diagnosed at amniocentesis are required.     

The effect of tibial curvature and fibular loading on the tibia index

The tibia index (TI) is commonly used to predict leg injury based on measurements taken by an anthropomorphic test device (ATD). The TI consists of an interaction formula that combines axial loading and bending plus a supplemental compressive force criterion. Current ATD lower limbs lack geometric biofidelity with regard to tibial curvature and fibular load-sharing. Due to differences in tibial curvature, the midshaft moments induced by axial loading are different in humans and ATDs. Midshaft tibial loading in the human is also reduced by load-sharing through the fibula, which is not replicated in current ATDs. In this study, tibial curvature and fibular load-sharing are quantified through CT imaging and biomechanical testing, and equations are presented to correct ATD measurements to reflect the loading that would be experienced by a human tibia.     

Day-of-week patterns in toxic air contaminants in southern California

Day-of-week mean ambient concentrations were computed for six high-cancer-risk toxic air contaminants (TACs): 1,3-butadiene, benzene, acetaldehyde, formaldehyde, carbon tetrachloride (CCl4), and perchloroethylene. Data from six urban sites in southern California, from 1989 through 2001, were analyzed. Graphical displays were used to search for repeated patterns. Benzene and 1,3-butadiene, emitted mainly by mobile sources, exhibit distinctly lower concentrations on Sundays and slightly lower concentrations on Saturdays and Wednesdays. Acetaldehyde and formaldehyde show some trace of a weekly pattern similar to that of benzene and 1,3-butadiene, but the pattern is not strongly marked. Perchloroethylene, used primarily as a dry-cleaning solvent, is also distinctly lower on Sundays. CCl4 does not show a day-of-week pattern.     

The Use of Natural Systems to Remediate Groundwater: Department of Energy Experience at the Savannah River Site

Natural remediation is moving toward the forefront as engineers clean groundwater at the Savannah River Site (SRS), a major Department of Energy (DOE) installation near Aiken, South Carolina. This article reviews two successful, innovative remediation methods currently being deployed: biosparging to treat chlorinated solvents and phytoremediation to address tritium in groundwater. The biosparging system reintroduces oxygen into the groundwater and injects nutrient compounds for in‐situ remediation. The system has greatly reduced the concentrations of trichloroethylene (TCE) and vinyl chloride in wells downgradient from a sanitary landfill (SLF). Phytoremediation is an emerging technology that promises effective and inexpensive cleanup of certain hazardous wastes. Using natural processes, plants can break down, trap and hold, or transpire contaminants. This article discusses the use of phytoremediation to reduce the discharge of tritium to an on‐site stream at SRS. © 2002 Wiley Periodicals Inc. *     

COST‐EFFECTIVE POINT‐NONPOINT TRADING: AN APPLICATION TO THE SUSQUEHANNA RIVER BASIN1

ABSTRACT: Point‐nonpoint trading has been suggested as a relatively efficient approach for reducing nutrient pollution in the Chesapeake Bay and elsewhere. However, relatively little economic research has examined the design of trading programs involving nonpoint sources. The purpose of this paper is to investigate the economics of several fundamental design choices for point‐nonpoint trading programs. The Susquehanna River Basin (SRB) in Pennsylvania as an example, although many of the insights should generally apply to other regions as well.     

Conceptualizing Sustainability: Simulating Concrete Possibilities in an Imperfect World

This paper uses a cultural model approach to interpret and analyse the impact of an interactive computer simulation tool (GB-Quest) on the possibility of fostering dialogue about sustainability in southwestern British Columbia, Canada. We define cultural models theory, compare cultural models to mental models and illustrate some basic features of cultural models. We then describe the research process in which participants engaged in conversation, guided and facilitated by GB-Quest, about sustainability. Findings suggest that the use of cultural models frameworks reinforces participants' understanding of sustainability. In reflecting on their prior models of sustainability, we argue that study participants can elucidate how cognitive conceptual resources reflect publicly shared knowledge (Turner, 2004).     

A Hydrologic/Water Quality Model Applicati11

Abstract: This paper presents a procedure for standard application of hydrologic/water quality models. To date, most hydrologic/water quality modeling projects and studies have not utilized formal protocols, but rather have employed ad hoc approaches. The procedure proposed is an adaptation and extension of steps identified from relevant literature including guidance provided by the U.S. Environmental Protection Agency. This protocol provides guidance for establishing written plans prior to conducting modeling efforts. Eleven issues that should be addressed in model application plans were identified and discussed in the context of hydrologic/water quality studies. A graded approach for selection of the level of documentation for each item was suggested. The creation and use of environmental modeling plans is increasingly important as the results of modeling projects are used in decision‐making processes that have significant implications. Standard modeling application protocols similar to the proposed procedure herein provide modelers with a roadmap to be followed, reduces modelers’ bias, enhances the reproducibility of model application studies, and eventually improves acceptance of modeling outcomes.