纳米铜颗粒的种间毒性关系

纳米颗粒的种间毒性关系尚无明确结论,因此很难判断纳米颗粒对未进行毒性测试的物种的风险如何。本文作者将5种水蚤(Daphnia magna, Daphnia pulex, Daphnia galeata, Ceriodaphnia dubia, Chydorus sphaericus)暴露于4种不同粒径的纳米铜颗粒(CuNPs)和1种亚微米铜颗粒的悬浊液中,考察物种的形态特征与CuNPs急性毒性的关系。结果显示,杆状的CuNPs比球状的CuNPs毒性更低。纳米铜颗粒与溶出铜离子均对CuNPs的毒性有贡献,其中,当新生蚤的体长、体表面积和身体体积更小时,5种悬浊液中颗粒的毒性更大。5种蚤的身体体积与5种CuNPs的毒性显著相关(r_adj²>0.51, p < 0.001),78-nm CuNPs与蚤身体体积的相关性最好 (r_adj²?=?0.95, p < 0.001)。这个研究可以为纳米颗粒对有相似外形特征的物种进行毒性种间外推提供线索。
精选自Lan Song, Martina G. Vijver, Geert R. de Snoo and Willie J.G.M. Peijnenburg. Assessing toxicity of copper nanoparticles across five cladoceran species. Environmental Toxicology and Chemistry: Volume 34, Issue 8, pages 1744–1750, August 2015. DOI: 10.1002/etc.3000
详情请见http://onlinelibrary.wiley.com/doi/10.1002/etc.3000/full     

Combustion products toxicity risk assessment in an offshore installation

Products of a hydrocarbon fire accident have both chronic and acute health effects. They cause respiratory issues to lung cancer. While fire is the most frequent phenomenon among the offshore accidents, predicting the contaminants’ concentration and their behavior are key issues. Safety measures design, such as ventilation and emergency routes based only on predicted contaminants’ concentration seems not to be the best approach. In a combustion process, various harmful substances are produced and their concentration cannot be added. The time duration that any individual spends in different locations of an offshore installation also varies significantly. A risk-based approach considers the duration a person is exposed to contaminants at various locations and also evaluates the hazardous impacts. A risk-based approach has also an additivity characteristic which helps to assess overall risk.Through the current study, an approach is proposed to be used for risk assessment of combustion products dispersion phenomenon in a confined or semi-confined facility. Considering CO, NO₂ and CH₄ as the contaminants of concern, the dispersion of the substances over the layout of the facility after a LNG fire is modeled. Considering different exposure times for three major parts of the facility including the processing area, office area and the accommodation module, the risk contours of CO, NO₂ and CH₄ over the entire facility are developed. The additivity characteristic of the risk-based approach was used to calculate the overall risk. The proposed approach helps to better design safety measures to minimize the impacts and effective emergency evacuation planning.     

吡虫啉的生物效应研究

应用不同的生物材料对新型杀虫剂的生态效应进行了研究，吡虫啉对泽蛙蝌蚪，黑斑蛙蝌蚪及青Jiang鱼的急性毒性表明，吡虫啉属于低毒农药，蚕豆根尖微核试验结果呈阴性，揭示其无致突变效应。     

TCC＆TCS对废水处理中生物相的急性毒性试验

研究了TCC(3,4,4′-Trichlorocarbanilde)、TCS(2,2,4′-Trichloro-2′-hydroxydiphenyl)对废水生物处理中的原生动物的急性毒性作用。结果表明:TCC对原生动物的48h半数致死浓度LC_(50)为25000μg/L,TCS48hLC_(50)为23000μg/L,TCC＆ TCS浓度与原生动物的半数致死时间LT_(50)呈明显的负相关;TCC ＆ TCS对原生动物的最大无作用浓度分别为15mg/L和11mg/L,这提示污染源排放的废水到达曝气池时TCC ＆ TCS的含量应低于15mg/L和11mg/L。     

Effect of quinalphos on blood enzymes and its acute toxicity in bubalus bubalis

Abstract

The acute toxic effects of quinalphos (0,0‐diethyl 0–2‐quinoxalyl phosphorothioata) uere investigated in male buffalo calves. Quinalphos was administered in single oral doses of 5, 7.5, 8.5 and 10 mg/kg body wt. and its effects on erythrocyte and plasma cholinesterases, serum aspartate aminotransferase and blood glucose were studied at various time intervals. The lowest dose (5 mg/kg) produced no apparent toxic symptoms. All the animals given highest dose (10 mg/kg) died within 60–82 hours after dosing. Quinalphos at all the dose levels markedly inhibited the erythrocyte and plasma cholinesterases (68–100%) and significantly elevated the levels of serum aspartate aminotransferase and blood glucose. Seven days after the administration of quinalphos, the blood cholinesterases in survivors remained inhibited to the extent of 41–77% whereas the levels of serum aspartate aminotransferase and blood glucose were comparable to control values.     

National short-term dietary exposure assessment of a selected group of pesticides in Argentina

ABSTRACT

An evaluation of acute dietary exposure to pesticide residues, applying deterministic and stochastic methods, was performed for a selected group of pesticides in two representative age groups from Argentina. Thus, 28 active ingredients (a.i.) and 75 food items were evaluated for the group of 2–5-year-old children, while 9 a.i. and 59 food items were considered for the 10–49-year-old women group. A deterministic assessment was conducting following the Food and Agriculture Organization (FAO) and World Health Organization (WHO) procedure but using the national maximum residue limits (MRLs) as pesticide residue concentration data, while in the stochastic approach, a theoretical distribution modeled with the available information was used. Food consumption data were obtained from the 2004–2005 comprehensive national nutrition and health survey. The risk was estimated by comparing the short-term dietary exposure with the acute reference dose (ARfD) values for each pesticide-food combination evaluated. In the deterministic assessment, 173 (39.1%) and 40 (31.3%) combinations exceeded the ARfD thresholds for the 2–5-year-old children and 10–49-year-old women groups, respectively. This conservative study generated relevant information as a first stage of acute dietary risk assessment in Argentina.     

Acute toxicity of acaricide in lizards (Agama agama) Inhabiting dog kennel in Ibadan, Nigeria: An environmental hazard in urban vector control

Acute toxicity of an acaricide (Nuvan^® 1000 EC) in lizards (Agama agama) was observed within 2 minutes spraying of the acaricide in an enclosed dog kennel; heavily infested by ticks in urban area of Ibadan city, South western Nigeria. The acaricide was used at the 0.5% concentration recommended by the manufacturer (Novartis). A lizard which emerged from the kennel during the acaricide spraying exhibited acute signs of toxicity which consisted of shivering, gasping and death. The clinical signs of the acute toxicity manifested in the affected lizard resembled central nervous system (CNS) breakdown or neurotoxicity. Also, two lizards (one female and one male) were found dead in the kennel in the second and third days after the single acaricide spraying operation. The acute acaricide toxicity in lizards observed in this study portrayed the danger of environmental hazard to non-target commensal organisms and it is the first reported case in the area.     

Activated carbon adsorption,activated sludge and ozonation treatments evaluated by impact intensity based on acute toxicity test

A Toxicity Reduction Evaluation (TRE) conducted on various water treatments was successful in optimizing the acute toxicity of the final effluent. In particular, we found that the acute toxicity of the sample water treated by a water treatment process should not be correlated with the concentrations of the parent compounds still remaining in the water. Therefore, it was concluded that an acute toxicity test based on a bioassay must be performed in order to evaluate the efficiency of the water treatment process for various effluents containing environmental pollutants. In addition, the treatability and the resultant toxicity was evaluated as a simple scoring system. The scoring system ranked the treated water in three classes of toxicity with the calculation of several factors for the concerned toxicity. Using an impact evaluation based on the score of the characteristics, different water treatment processes could be directly compared. The new methodology presented here is specifically effective in listing possible unit operations for a water treatment process based on the impact, and thereby enables targeted and cost-effective water treatment.     

Acute/chronic ratios to estimate chronic toxicity from acute data

Acute toxicity of 25 narcotic compounds to D. magna was determined in this paper. Acute/ Chronic Ratios (ACRs), which are often used to estimate chronic toxicity from acute toxicity data, are discussed based on Quantitative Structure‐Activity Relationships (QSARs) of the compounds between both acute and chronic toxicity data and n‐octanol/water partition coefficients, and an improved equation is derived to estimate chronic toxicity data from acute toxicity data. Application of the improved equation and ACRs is illustrated for D. magna and fathead minnow to estimate chronic toxicity from acute toxicity.