Prenatal diagnosis of the fragile X syndrome using fetal blood and amniotic fluid

Nineteen pregnancies at risk for the Martin–Bell syndrome have been monitored during the second trimester for the presence of the fragile Xq27. Of the 19 potential carrier mothers, 14 showed the presence of the fragile X in their lymphocytes at a level of 4 per cent or above. As one was a twin pregnancy, fetal blood was obtained at fetoscopy from 20 fetuses and amniotic fluid obtained simultaneously from 19 of them. Of the 20 fetuses, 18 were males (including both of the twins) and two were females. Of these 18 males, seven were found to carry the fragile Xq27 in lymphocytes and subsequently six of the seven were terminated. The diagnosis was confirmed in five of the six terminated fetuses (the sixth case was a patient whose pregnancy was terminated abroad) and also in a full-term male baby. Five of the seven males without the marker X who came to term had their karyotypes confirmed post natally. Of the two female fetuses one was found to be a carrier of the fragile X and the other was not. Both babies had full-term deliveries and both had their karyotypes confirmed post natally. In some cases the diagnosis made in fetal lymphocytes was confirmed later in amniocytes.     

溢油指示物(指标)的HPLC-FLD-GM(1,1)研究

通过对油种、风化和HPLC-FLD实验条件的模糊最大矩阵元评价,确定表征溢油指示物(指标)的HPLC-FLD-GM(1,1)的建模数据信息点.结果表明,溢油风化GM(1,1)模式的预测精度较高,可用于溢油风化预测研究.     

13X分子筛处理含苯胺废水的实验研究

以天然岩石矿物为原料，经过较简单的工艺过程合成的13X沸石分子筛用于吸附水中苯胺的实验研究，结果表明：分子筛对苯胺的吸附速率非常快，吸附时间为10min时，吸附基本害饱和；一般当分子筛用量为10g/L时，水中苯胺的去除率达95％；随着pH值的增加，苯胺在分子筛上的吸附率减小；温度增加，吸附率有所增加，但常温下，苯胺的吸附率也能达到93％；13X分子筛对苯胺的最大吸附量可达10mg/g，其吸附规律较好地符合Furendlich吸附等温式；饱和了苯胺的分子筛，用质量浓度为20％、温度为60℃的氯化钠溶液洗脱，解吸率近于100％，且解吸后的分子筛在未经任何处理的情况下仍能吸附苯胺；说明采13X分子筛处理含苯胺废水，不仅吸附效果好，而且再生能力也强，为实际处理含苯胺废水提供了可行性依据。     

Cold-modeling study of a circulating fluidized-bed reactor for flue gas desulfurization (FGD)

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合肥台测震CTS-1系统处理软件

主要介绍了地震数据断记报警软件及其相关地震数据分类处理软件,此软件一方面保证了地震监测数据的连续性,另一方面使科研人员查询地震事件波形,迅速快捷,并可对典型地震事件和震相特征进行查看,提高对一些特殊地震震相的识别,从而也提高了地震的分析水平.     

Lipophilicity and Metabolic Route Prediction of Imidazolium Ionic Liquids * (6 pp)

- Aims and Background. Ionic liquid application in industry will offer several excellent solutions, but it also means that they will enter the environment sooner or later. Responsible product design should always take into consideration not only technological demands, but also the risks arising out of possible toxicity and ecotoxicity. In our strategy we are aiming to understand the fate of these entities through their life cycle in the environment as a complimentary element of their design. This paper presents results on the lipophilicity of selected imidazolium ionic liquids, a parameter that plays a key role in environmental and biological distribution. Additionally, the prediction of the most stable metabolite of a 1-butyl-3-methylimidazolium (BMIM) cation – a congener representative of this group of compounds is presented. Materials and Methods Lipophilicity was evaluated by means of reversed phase and immobilized artificial membrane chromatography and further compared to calculated data. Theoretical prediction of lipophilicity was undertaken using fragmental methodology combined with manual calculations of the geometric bond factor for quaternary ammonium and the electronic bond factor due to the presence of a charge. Results and Discussion All the substances studied are characterized by very low partition coefficients, and lipophilicity varies linearly with elongation of the n-alkyl chain. Prediction of metabolic routes was based solely on thermodynamic data of the radical intermediates formed during the reaction with the cytochrome P450 system. The energetically most stable radical structure is generated by hydrogen abstraction from the gamma position of the BMIM cation. Conclusions and Recommendations. The experimentally measured and theoretically estimated lipophilicity coefficients obtained for all the compounds studied generally indicate a relatively low lipophilicity and thus preferable partition to the aqueous phase. By means of thermodynamic data, it was also confirmed that the energetically most stable radical structure is generated by hydrogen abstraction from the gamma position on the alkyl chain in the 1-alkyl-3-methylimidazolium cation, as a result of which the C1 atom is preferentially oxidized. - * The basis of this peer-reviewed paper is a presentation at the 9th FECS Conference on 'Chemistry and Environment', 29 August to 1 September 2004, Bordeaux, France.     

Bioassay zur Bestimmung von TCDD-Toxizit?ts?quivalenten (TEQ) von Umweltproben und Reststoffen

Zusammenfassung  Polychlorierte aromatische Kohlenwasserstoffe (PHAK), z.B. 2,3,7,8-Tetrachlordibenzo-p-dioxin (TCDD), weisen eine Vielzahl von toxischen Wirkungen und biologischen Effekten auf. Die Substanzklasse der PHAK besitzt die Eigenschaft der Bindung an ein cytosolisches Rezeptor-Protein, gefolgt von der Synthese bestimmter Genprodukte, u.a. von Cytochrom P450 1A1 (CYP 1A1). In dieser Arbeit wird ein Bioassay beschrieben, der erlaubt, die Induktion von CYP 1A1 als Summenparameter für die biologische Wirksamkeit der kritischen, halogenierten Verbindungen in komplexen Umweltmatrizes zu bestimmen. Zur Abtrennung von Substanzen aus den Extrakten von Umweltproben (z. B. Naturstoffe und polyzyklische aromatische Kohlenwasserstoffe), die den Bioassay st?ren k?nnen, wurde ein Ein-S?ulen-Clean-up entwickelt. Die biologisch ermittelten TEQ-Werte stimmen gut mit den Resultaten der chemischen Analytik überein. Der Bioassay in Kombination mit dem Clean-up bietet eine zeitsparende und kostengünstige M?glichkeit zur Untersuchung von Umweltproben.      

用HL离心萃取器处理含对硝基酚废水的研究

溶剂萃取法是目前回收处理含高浓度对硝基酚废水的有效方法。选用QH-1为萃取剂，采用HL离心萃取器对含对硝基酚废水的处理进行了实验研究。实验结果表明，对于对硝基酚硝酸溶液-QH-1体系，对硝基酚的分配比是1103．4，用Φ20mmHL离心萃取器处理对硝基酚废水时，在合适的操作条件下，单级传质级效率E和三级串联萃取率ρ都可达99％以上，三级串联的反萃率也可达98％以上。     

生物铁法去除维生素B1生产废水中COD的试验研究

生物铁法是一种新型的强化活性污泥法，处理高浓度、难生物降解维生素B1生产废水具有很大的优势。当进水COD浓度维持在8000mg／L时，COD的去除率可达94％以上，比普通活性污泥法高出9．7％。生物铁法污泥絮凝沉淀效果好，能保证系统有较高浓度的回流污泥，从而使曝气池的污泥浓度得到提高，COD的去除率也会相应地提高。