Genetic considerations in the prenatal diagnosis of overgrowth syndromes

Large (>90%) for gestational age (LGA) fetuses are usually identified incidentally. Detection of the LGA fetus should first prompt the provider to rule out incorrect dates and maternal diabetes. Once this is done, consideration should be given to certain overgrowth syndromes, especially if anomalies are present. The overgrowth syndromes have significant clinical and molecular overlap, and are associated with developmental delay, tumors, and other anomalies. Although genetic causes of overgrowth are considered postnatally, they are infrequently diagnosed prenatally. Here, we review prenatal sonographic findings in fetal overgrowth syndromes, including Pallister-Killian, Beckwith-Wiedemann, Sotos, Perlman, and Simpson-Golabi-Behmel. We also discuss prenatal diagnosis options and recurrence risks. Copyright © 2009 John Wiley & Sons, Ltd.     

灾害基本成因研究

本文依据灾害的生态经济性质,在对各类灾害的具体成因进行概括与抽象的基础上,从地球系统、自然生态系统、社会经济系统、城市系统的运动与发展及灾害与这些系统的相互联系和相互作用等方面研究各类灾害的共同成因,即灾害的基本成因,并对其进行系统分析。     

渭、洛河下游“92·8”洪灾浅析

渭、洛河下游受三门峡水库回水淹没及影响,洪灾频繁。本文依据1902年8月惨重洪灾的实例,全面分析了洪水的特殊性和致灾因素,并从流域治理、水库水沙调度、防洪工程建设等方面提出了进一步减灾的措施。