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91.
Setting the stage for the review of the international estimate of short-term intake (IESTI) equation
Anke Richter Christian Sieke Hermine Reich Bernadette C. Ossendorp Nicolas Breysse Jason Lutze 《Journal of environmental science and health. Part. B》2018,53(6):343-351
ABSTRACTIn the framework of setting Maximum Residue Limits (MRLs) for pesticides, both chronic and acute health risks to consumers arising from the long-term and short-term dietary exposure to pesticide residues have to be assessed. The current internationally harmonized approach for assessing the acute dietary exposure is based on deterministic methods for calculating the IESTI (International Estimate of Short-Term Intake). Recently, it became apparent that the IESTI approach needs a revision in the light of new scientific and political aspects. The main reasons that require this review were the lack of an international harmonization of the methodology which implies trade barriers as well as difficulties in risk communication concerning the public trust in regulatory systems. The most recent milestone in the scientific debate on a possible revision of the IESTI equation was an international scientific workshop held in Geneva in September 2015. The main objectives of this meeting were the re-evaluation, and where possible, the international harmonization of the input parameters for the IESTI equations as well as the equations themselves. The main recommendations from the workshop were (i) to replace the highest residue and supervised trials median residue with the maximum residue limit (MRL), (ii) to use a standard variability factor of three, (iii) to derive the P97.5 large portion value from the distribution of consumption values of dietary surveys expressed as kg food/kg bw/d, and (iv) to remove the commodity unit weight from the equations. In addition, the application of conversion factors and processing factors was addressed. On the initiative of the (World Health Organization) WHO Collaborating Centre on Chemical Food Safety at the National Institute for Public Health and the Environment (RIVM), the Netherlands, an international working group with members from the French Agency for Food, Environmental and Occupational Health and Safety, France (ANSES), Australian Pesticides and Veterinary Medicines Authority, Australia (APVMA), German Federal Institute for Risk Assessment, Germany (BfR), Chemical Regulation Division, the United Kingdom (CRD), European Food Safety Authority (EFSA), and RIVM, the Netherlands was formed after the IESTI workshop to conduct a comprehensive impact assessment of the proposed changes of the IESTI equations. 相似文献
92.
以“丝绸之路”经济带上的河西走廊地区为研究对象,采用耦合分析法,构建环境承载力与生态弹性限度的耦合协调模型,在分析2001—2016年河西走廊生态环境承载力和生态弹性限度的基础上,探析河西走廊生态环境承载力与弹性限度的耦合协调度,评价生态环境承载力和生态弹性限度耦合协调阶段及区域生态环境质量水平,从区域和城市两个空间尺度分析生态环境耦合协调类型,为探索河西走廊生态环境可持续发展道路提供科学依据。结果表明:①2001—2016年,河西走廊生态环境承载力和生态弹性限度均呈现东南高、西北低的空间格局和缓慢波动上升趋势。②河西走廊生态环境耦合协调度呈现“东南高西北低,优劣破碎穿插”的空间格局特征,耦合协调度在0~0.5之间,生态系统处于低水平和拮抗耦合阶段,生态环境质量处于濒临失调阶段。③河西走廊生态环境承载力与生态弹性限度耦合协调度存在明显区域差异。河西走廊生态环境耦合协调度共分9个等级3个层次3个耦合协调阶段:高水平-磨合阶段区(良好协调、中度协调和初级协调区);中等水平-拮抗耦合阶段区(勉强协调、濒临失调和轻度失调区)和低水平区-低水平耦合阶段区(极度失调、严重失调和中度失调区)。④根据2001—2016年生态环境耦合协调状况将河西走廊五市分为4种耦合协调类型:高耦合协调增长型(张掖市、金昌市)、高耦合协调减少型(武威市)、中耦合协调增长型(嘉峪关市)和低耦合协调增长型(酒泉市)。各地区应因地制宜地制定发展战略,提高生态环境质量,推进生态环境持续协调发展。 相似文献
93.
94.
Pharmaceuticals and personal care products found in the Great Lakes above concentrations of environmental concern 总被引:2,自引:0,他引:2
The monitoring of pharmaceuticals and personal care products (PPCPs) has focused on the distribution in rivers and small lakes, but data regarding their occurrence and effects in large lake systems, such as the Great Lakes, are sparse. Wastewater treatment processes have not been optimized to remove influent PPCPs and are a major source of PPCPs in the environment. Furthermore, PPCPs are not currently regulated in wastewater effluent. In this experiment we evaluated the concentration, and corresponding risk, of PPCPs from a wastewater effluent source at varying distances in Lake Michigan. Fifty-four PPCPs and hormones were assessed on six different dates over a two-year period from surface water and sediment samples up to 3.2 km from a wastewater treatment plant and at two sites within a harbor. Thirty-two PPCPs were detected in Lake Michigan and 30 were detected in the sediment, with numerous PPCPs being detected up to 3.2 km away from the shoreline. The most frequently detected PPCPs in Lake Michigan were metformin, caffeine, sulfamethoxazole, and triclosan. To determine the ecological risk, the maximum measured environmental concentrations were compared to the predicted no-effect concentration and 14 PPCPs were found to be of medium or high ecological risk. The environmental risk of PPCPs in large lake systems, such as the Great Lakes, has been questioned due to high dilution; however, the concentrations found in this study, and their corresponding risk quotient, indicate a significant threat by PPCPs to the health of the Great Lakes, particularly near shore organisms. 相似文献
95.
通过对7种废气自动监测系统的比较研究和现场测试,提出了非分散红外法、紫外差分法、紫外荧光法、化学发光法等多种SO2和NO x自动监测技术在低浓度范围实现准确定量监测的性能评价方法,定义了CEMS的系统检出限及其主要影响因素。建议采用系统检出限、线性误差等关键参数作为低浓度CEMS的性能评价方法,提出将全系统多点标准气体校准或加标回收率作为验收和质控监督的基本方法。 相似文献
96.
97.
用对二甲氨基苯甲醛分光光度法测定水中水合肼,将显色剂用量由5.0 m L降至3.0 m L,比色皿厚度由30 mm增至50 mm,水样酸度由1 mol/L降至0.5 mol/L,同时增加低浓度校准曲线,实现对其方法检出限的优化。结果表明,优化后方法检出限由0.007 8 mg/L降至0.001 0 mg/L,精密度及加标回收率均符合规范要求,能够保证低浓度水样的准确测定。 相似文献
98.
Zhu Dajian 《中国人口.资源与环境(英文版)》2012,10(2):24-30
The core issue for China transition development in the next 30 years is to shift from the quantity growth model to the quality improvement model. The paper introduces the research progress in three key areas of sustainable development studies since the 1990s. It is pointed out that there is a well-being thresh-old at which the margin utility of economic growth for human well-being will decline, that there is an ecological limit beyond which more economic growth in terms of physical scale will be impossible, and that the creation of human well-being is related not only to the amount but also to the structure and efficiency of public expenditure from government. After an in-depth discussion on facts, origins and policy implications of each issue, some theory and policy thinking with long-lasting significance are raised for the transition development of China. 相似文献
99.
三面受火的方钢管混凝土柱耐火极限 总被引:1,自引:0,他引:1
编制了预测方钢管混凝土柱三面火灾作用下高温反应的数值分析程序,并将之用于不同荷载比、截面边长、长细比、荷载偏心率、钢材和混凝土强度及含钢率共480种工况下方钢管混凝土柱耐火极限参数分析,得到了三面火灾作用下方钢管混凝土柱耐火极限的主要影响参数及其影响规律。基于参数分析结果,定量给出了该受火条件下方钢管混凝土柱耐火极限的简化计算方法。研究结果表明:荷载比、截面边长、长细比是三面火灾作用下方钢管混凝土柱耐火极限的主要影响参数,表现为截面边长越大,荷载比和长细比越小,构件的耐火极限越大。由于存在极强偏心,当荷载作用点偏于背火面时荷载偏心率亦有较大影响。 相似文献
100.
Abstract Four sprays of 0.05 ana 0.10% phosalone were given on chilli (Capsicum annuum Linn.) crop at an interval of 15 days starting from 21 days after transplanting. Residues were determined in the green chilli fruits by GLC after cleanup of extract on multiband thin‐layer plate. The half‐lives of residues were 1.55 and 1.68 days on chilli fruits from the crop treated with four sprays of 0.05 and 0.10% phosalone respectively. The time required to reach the tolerance limit of 1 ppm after last spray with 0.05 and 0.10 % emulsion was 4.75 and 7.62 days respectively. Washing of fruits under tap water was found effective in bringing down the level of phosalone residues by 21.64 to 75.11 %. 相似文献