Impact of European legislation on marketed pesticides — A view from the standpoint of health impact assessment studies

The very significant impact of European legislation (Directive 91/414/EEC) on the authorization of plant protection products is reviewed herein, which has resulted in withdrawal of 704 active substances (AS) out of 889 assessed so far. The list of currently approved 276 AS includes 194 AS “existing” in the market before 1993 and 82 “new” AS introduced during the last 15 years. Results of toxicity characterization of the approved AS are also summarized, utilizing several well-known databases. Although significant data gaps exist for a rather large part of the approved AS, it is found that 84 AS are positive for at least one health effect (after chronic and/or acute exposure) including carcinogenicity, reproductive and neuro-developmental disorders, as well as endocrine disruption. The toxicity characterization results of this study are compared to those of recent assessments by other organizations (KemI, the Swedish Chemicals Agency, and the Pesticide Safety Directorate of the UK), where interpretation and use is made of AS “cut-off” criteria foreseen in new EU legislation. These studies report a comparatively smaller AS number with positive toxicity characterization. The possibility of some additional AS withdrawal in the near future, combined with the rather small rate of new AS introduction (approx. 5 per year) suggest that the list of approved AS over the next 10–15 years may not change very drastically. Consideration of the above trends is necessary and instructive in evaluating results of existing health impact assessment (HIA) studies, as well as in planning new ones. Due to the very drastic change in the number and type of marketed AS, that took place within the past 8–9 years, it is suggested that new HIA studies (based on epidemiological data after year 2000) should focus on a rather short time frame and, therefore, on appropriate cohort groups, e.g. young children. For the same reason, results of epidemiological studies of the past (involving banned AS) should be carefully interpreted and used with caution.     

基于灰色模糊理论的流域水电规划环境影响综合评价

结合模糊优选理论和灰色关联分析方法,提出灰色模糊综合评价法,该方法将灰色关联分析作为优属度确定的隶属度计算方法;提出理想环境序列建立遵循的原则,引入梯形模糊数实现定性指标量化并采用变异系数法确定评价指标权重.应用灰色模糊综合评价法对黄河流域河段水电规划的高坝方案和多级开发方案进行了比选研究,计算了两个方案的优属度及其开发性因子、稳定性因子、保护性因子、经济活力因子、社会可接受因子、环境风险因子等6个指标层优属度,结果表明,多级开发方案总体优于高坝方案;多级开发方案的保护性远好于高坝开发方案,而高坝方案的开发性略好于多级开发方案,稳定性、经济活力、社会可接受、环境风险等因子两种方案比较接近.评价结果与流域实际情况比较符合,证明该方法是一种有效的方法.     

城市污水处理厂环境影响评价中的问题探讨

针对城市污水处理厂项目的特点,分析探讨了此类项目环境影响评价中应注意的几个问题。     

Environmental Exposure of Aquatic and Terrestrial Biota to Triclosan and Triclocarban1

Abstract: The synthetic biocides triclosan (5‐chloro‐2‐(2,4‐dichlorophenoxy)phenol) and triclocarban (3,4,4′‐trichlorocarbanilide) are routinely added to a wide array of antimicrobial personal care products and consumer articles. Both compounds can persist in the environment and exhibit toxicity toward a number of biological receptors. Recent reports of toxicological effects in wildlife, human cell cultures, and laboratory animals have heightened the interest in the occurrence of these biocide and related toxic effects. The present study aimed to summarize published environmental concentrations of biocides and contrast them with toxicity threshold values of susceptible organisms. Environmental occurrences and toxicity threshold values span more than six orders of magnitude in concentration. The highest biocide levels, measured in the mid parts‐per‐million range, were determined to occur in aquatic sediments and in municipal biosolids destined for land application. Crustacea and algae were identified as the most sensitive species, susceptible to adverse effects from biocide exposures in the parts‐per‐trillion range. An overlap of environmental concentrations and toxicity threshold values was noted for these more sensitive organisms, suggesting potential adverse ecological effects in aquatic environments. Affirmative evidence for this is lacking, however, since studies examining environmental occurrences of biocides vis‐à‐vis the health and diversity of aquatic species have not yet been conducted.     

电厂对珍禽保护区的环境影响评价实例探讨

以位于自然保护区边缘的火电厂建设项目环境影响评价为实例,阐述了火电厂生态环境评价中对自然保护区珍稀鸟类的保护方法,以供类似项目的生态环境影响评价借鉴。     

基于模糊层次分析法的应急能力评估方法探讨

对危险行业的安全生产事故应急能力进行安全评估,可以持续改进应急管理工作,提高事故应急能力的总体水平。作为综合性的安全评估方法,层次分析法在安全研究的多个领域中得到了应用。通过介绍安全生产事故应急管理能力及其评估要求,分析国内外应急能力评估的现状,提出了应急能力评估体系建立的总体思路。论述了事故应急能力评估指标集的建立方法和基于模糊层次综合评价法的评估模型构建方案,初步建立起事故应急管理能力评估方法。     

层次分析法的改进及在安全决策中应用的研究

本文根据化工行业的特点及调研资料,建立了影响安全的层次结构模型即安全指标体系。并利用改进式层次分析法（IAHP）对该体系进行分析,得出了各个因素对安全的影响系数（权重）。     

The 2030 Agenda for Sustainable Development and China’s implementation

The concept of sustainable development has experienced great development and change at different levels of theoretical connotation and practical implementation since 1960s and 1970s when it was first proposed. People’s understanding of the relationship between economy, society, and environment has been continuously deepened over the years. When it came to the end of 2015, it is necessary to examine the results of the United Nations Millennium Development Goals on sustainable development, and at the same time, the post-2015 framework and guidance on sustainable development at the global level were to be made, including the ideas, action plans, key areas that would guide the global sustainable development. The 2030 Agenda for Sustainable Development has developed a 5P theoretical framework of being people-centered, global environmental security, sustained economic prosperity, social justice and harmony and partnership promotion, including a political declaration, 17 overarching goals and 169 specific targets, specific ways of implementation, as well as the follow-up. It is the road map to achieve global sustainable development and meet the requirements of the millennium development goals. This paper summarizes the understanding of the concept of sustainable development from its origin, its significant development, to the proposition and development of the 2030 Agenda for Sustainable Development, and its strategic impact on China.     

阿维菌素对中华绒螯蟹肝胰腺氧化胁迫效应和组织结构的影响

采用半静态染毒法,研究不同浓度(1.6、8.0、16.0μg·L-1)阿维菌素在胁迫中华绒螯蟹12、24、48、96 h时肝胰腺超氧化物歧化酶(SOD)、过氧化氢酶(CAT)活性和丙二醛(MDA)积累量等氧化胁迫相关指标的变化;并在胁迫60 d时,记录各实验组和对照组中华绒螯蟹肝胰腺颜色的变化并进行组织病理观察。3个阿维菌素浓度组为实验组,空白组和溶剂组为对照组。结果表明在整个实验过程中空白组和溶剂组各个时间点各项指标之间无显著差异(P>0.05);低浓度(1.6μg·L-1)组SOD和CAT活力变化不显著(P>0.05);中浓度(8.0μg·L-1)组SOD和CAT活力变化趋势一致,持续被诱导,SOD活力在24 h以后显著高于空白组(P<0.01),CAT活力在48 h以后显著高于空白组(P<0.01);高浓度(16.0μg·L-1)组SOD和CAT活力在12 h~24 h之间变化趋势一致,表现为显著升高(P<0.05),但是在48 h之后,SOD活力显著下降(P<0.05);96 h时,高浓度组SOD活力显著低于空白组(P<0.01),而CAT活力显著高于空白组(P<0.01);在整个实验过程中各实验组MDA积累量逐渐增加,高浓度组氧化胁迫指标的变化幅度大于低浓度组。胁迫60 d时,取样观察可见对照组中华绒螯蟹肝胰腺正常,各实验组中华绒螯蟹肝胰腺发生了不同程度的病变,肝胰腺颜色由最开始的橘黄色变成了淡黄色、黄白色甚至白色,高、中、低各浓度组肝胰腺白化所占的比例分别是66.6%、57.1%和25.0%。组织病理分析显示,淡黄色肝胰腺的病理变化主要是B细胞数量减少,肝胰腺上皮细胞部分肿大并出现空泡;黄白肝病理观察可见肝胰腺上皮细胞中空泡数量增多,体积增大,且空泡内出现内容物,细胞核固缩;白肝的病理表现主要是基膜增厚,上皮细胞大量脱落,散落在管腔中,空泡数量进一步增多,肝胰腺的生理功能受损。由此得出,阿维菌素会对中华绒螯蟹肝胰腺造成氧化胁迫和组织损伤,且阿维菌素和对肝胰腺的氧化胁迫效应和组织结构损伤程度有一定的剂量-效应关系。