Tools for an enhanced solvent properties screening in the early stages of pharmaceutical process development

The objective of this research was the implementation of tools for the evaluation of solvents trough property screening in the early stages of process development. An important feature of the tools is that the implementation of indexes, scores, or weights is avoided. Information already available from the literature was stored in a database in order to turn raw data into decision making information. As a result, a solvent radar chart, a solvent representation table, and a solvent telescopying tool were developed in an ASP.NET application. The synthesis of Propranolol was used as study case in order to explore the selection of solvents in the early stages of process development. The replacement of diethyl ether was possible in the extraction step, while solvent choices were detected for potential telescoping for extraction and crystallisation steps. Solubility was found as a critical parameter in telescoping analysis. The methodology proposed enhanced the view towards a more holistic perspective and a more robust solvent screening process. As a consequence, the next steps into solvent evaluation and process development can be reduced.     

Remote sensing technology and land use analysis in food security assessment

ABSTRACT

Climate change and a rapidly growing human population have put ever greater strains on the global food system. Although the number of food insecure people in the world has reached a record low, changing land use and climate variability will threaten our ability to maintain this progress. Profound changes in the structure of economies around the world have affected agricultural production and how food is delivered to the consumer. This paper explores connections between land use, environmental change and food availability, access, and utilization. Each of these elements of food security has vulnerabilities to changing environmental conditions and land use that can be explored using satellite remote sensing observations. Technology is a key way environmental changes can be quantified and used in food security assessment.     

ASP.NET在安全信息管理系统中的应用

安全信息管理系统主要包括对安全信息数据的收集、存储、加工处理、传递和利用等功能.主要阐述了B/S结构的特点,以及一种全新的Web开发技术ASP.NET在安全信息管理系统中的应用.这使在Web上对安全信息数据进行增、删、改、查操作成为可能,对防止事故发生,减少由事故造成的损失,提高企业的安全管理水平等具有重要的意义.     

基于.NET的产品故障管理信息系统设计与建模

首先介绍了基于.NET平台的Pet Shop体系架构,然后分析了产品的故障信息,并说明了故障案例数据库的设计思路,最后介绍了产品故障管理信息系统的功能设计、结构设计,并详细描述了系统的UML建模过程,给出了系统的用例图、活动图、时序图.     

煤矿安全质量标准化管理信息系统的开发与应用

针对我国安全质量标准化工作日常考核和汇总繁琐且不利于统计分析的问题,采用ASP.NET与SQL Server的技术,以国家煤矿安全质量标准化及考评办法为依据,融合煤矿企业安全质量标准化的现场管理考评实际,开发设计了包括政策查询、考评标准和方法查询学习、考核评级、结果查询、统计分析、后台管理在内的6大功能模块的煤矿安全质量标准化管理信息系统,并在某矿业集团进行了实际应用。在理论与实例应用的基础上,得出系统可以有效对安全质量标准化标准自查过程的记录,对隐患按项目进行归类管理,对检查结果进行统计分析,及时跟踪处理现场存在的安全隐患。     

江苏省排污申报信息管理系统设计

排污申报登记是环境管理的基础性工作,需要现代信息技术提供有力的技术保证.笔者通过对江苏省排污申报工作的需求分析、信息管理系统的系统设计、数据库设计、功能模块、.NET技术架构方法及实施、系统的应用概况等方面的介绍,给出了一种开发环境信息系统技术方面的新思路和新方法.      

基于SQL Server数据库技术在环境腐蚀数据中的应用

介绍了基于VB.NET访问SQL Server数据库技术在环境腐蚀数据中的应用设计与实现,重点阐述SQL Server数据库技术在环境腐蚀数据中查询的设计思想和体系架构,并对其中涉及的若干关键技术进行了较为详细的介绍.