秦皇岛市空气污染对呼吸系统疾病的影响

通过分析秦皇岛市2011—2012年每日的API值及大气PM10、 SO2、 NO2的日平均浓度变化与同时期的呼吸系统疾病日门诊人数资料,建立了时间序列分析数学模型,分析了秦皇岛市主要大气污染物与呼吸系统疾病发病的关系。发现秦皇岛市大气污染物的浓度与居民呼吸系统疾病之间存在着一定的正相关性,污染物浓度升高,居民呼吸系统疾病的就诊人数随之增加。     

Activity-Based Patterns of Everyday Mobility: The Potential for Long-Term Behaviour Change Across Five Groups of Travellers

Abstract

Significant differences in our mobility patterns can be found in relation to both range/distance and form. While some people travel on multiple occasions to global destinations over the course of a year, others travel mainly locally, that is, by bicycle or on foot. Policymakers and planners need to have a clear conception of the different mobility patterns if they are to develop valid and precise measures promoting more sustainable forms of mobility. This paper points to five key mobility types based on an exploratory cluster analysis of approximately 20,000 Norwegian travel diaries. Three of the defined groups are dominated by the private car, while two are oriented towards the use of public transport, bicycling and walking. The key differences and similarities between the mobility types are discussed and the relationship between everyday travel patterns and long-distance travel is analysed. Opportunities and challenges for transformations in the everyday travel habits of the five groups are discussed in the final section.     

Two decades,three WEEE systems: How far did EPR evolve in Korea's resource circulation policy?

Extended producer responsibility (EPR) has become a dominant policy paradigm for the management of waste electrical and electronic equipment (WEEE) in the last two decades. In South Korea the principle has guided the evolution of the resource circulation policy even before its official introduction through a revision of the recycling law in 2002. Elements of producer responsibilities could be found in the producer-based deposit refund system (DRS) a decade earlier and they were strengthened through the enactment of a new resource circulation law in 2008. This article reviews the policy changes in South Korea for the management of WEEE during the past 20 years. The focus of the analysis is on the impacts of EPR and the producers’ responses that were expressed through the quantity and the quality of material flows in the society. The findings are discussed in light of international experiences in order to outline measures to improve the effectiveness of the EPR-based resource circulation policy that could have broader implications beyond the case study.     

Life-cycle phosphorus use efficiency of the farming system in Anhui Province,Central China

The rapid increase of phosphorus (P) use in farming has raised concerns regarding its conservation and environmental impact. Increasing the P use efficiency (PUE) is an approach to mitigating these adverse impacts. In this study, we applied substance flow analysis (SFA) to establish a life-cycle P use efficiency model to determine the life-cycle PUE of the farming system used in Anhui Province in 2011, which is typical of the agriculture practiced in central China. Based on this model, the P flows and PUEs of five subsystems were identified and quantified: crop farming, crop processing, livestock breeding, rural living, and urban living. The three largest P flows were found in the crop farming and livestock breeding subsystems; it can therefore be concluded that these subsystems have substantial impacts on the entire farming system. In contrast, the PUEs of crop farming, rural consumption, and livestock breeding subsystems presented the three lowest PUEs (58.79%, 71.75%, and 76.65%, respectively). These results were also consistent with the finding that the greatest P losses occurred in crop farming and livestock breeding. Consequently, the study proposes that great potential exists for increasing PUEs in the farming system of Anhui, and several of the most promising measures could be combined for improving PUEs. Finally, the study assesses data quality and presents a sensitivity analysis for use in interpreting the results. The study also shows that improving PUE and decreasing P losses in farming systems through improved nutrient management must be considered an important issue, and this study represents valuable experience in resource conservation and agricultural development in China.     

System dynamics model for analyzing effects of eco-design policy on packaging waste management system

EU's long-term objective is to become a recycling and resource effective society, where waste is utilized as a resource and waste generation is prevented. A system dynamics model was developed to analyze the policy mechanisms that promote packaging material efficiency in products through increased recycling rates. The model includes economic incentives such as packaging and landfill taxes combined with market mechanisms, behavioral aspects and ecological considerations in terms of material efficiency (the packaging material per product unit, recycled fraction in products). The paper presents the results of application of various policy instruments for increasing packaging material efficiency and recovery rate and reducing landfilled fraction. The results show that a packaging tax is an effective policy instrument for increasing the material efficiency. It ensures the decrease of the total consumption of materials and subsequent waste generation. The tax helps to counteract a rebound effect, which, as identified by the analysis, can be caused by reduced material costs due to eco-design. The model is applied to the case of Latvia. Yet, the elements and structure of the model developed are similar to waste management systems in many countries. By changing numeric values of certain parameters, the model can be applied to analyze policy mechanisms in other countries.     

A dual-interval fixed-mix stochastic programming method for water resources management under uncertainty

In this study, a dual-interval fixed-mix stochastic programming (DFSP) method is developed for planning water resources management systems under uncertainty. DFSP incorporates interval-parameter programming (IPP) and fuzzy vertex analysis (FVA) within a fixed-mix stochastic programming (FSP) framework to address uncertain parameters described as probability distributions and dual intervals. It can also be used for analyzing various policy scenarios that are associated with different levels of economic consequences since penalties are exercised with recourse actions against any infeasibility. A real case for water resources management planning of Zhangweinan River Basin in China is then conducted for demonstrating the applicability of the developed DFSP method. Solutions in association with α-cut levels are generated by solving a set of deterministic submodels, which are useful for generating a range of decision alternatives under compound uncertainties. The results can help to identify desired water-allocation schemes for local sustainable development that the prerequisite water demand can be guaranteed when the available water resource is scarce.     

Environmental resource footprinting of drug manufacturing: Effects of scale-up and tablet dosage

The formulation and scale-up of batch processes is one of the major challenges in the development of pharmaceutical dosage forms and at the same time a significant resource demanding process which is generally overlooked in environmental sustainability assessments. First, this paper proposes general trends in the experience curve of cumulative resource consumption of pharmaceutical tablet manufacturing of PREZISTA^® 800 mg through wet granulation (WG) at four consecutive scales in both R&D and manufacturing environments (resp. WG1 = 1 kg/h, WG5 = 5 kg/h, WG30 = 30 kg/h and WG240 = 240 kg/h). Second, the authors aim at evaluating the environmental impact from a life cycle perspective of a daily consumption of PREZISTA^® 2× 400 mg tablets versus the bioequivalent PREZISTA^® 800 mg tablet which was launched to enhance patient compliance. Environmental sustainability assessment was conducted at three different system boundaries, which enables identification, localization and eventually reduction of burdens, in this case natural resource extraction. Exergy Analysis (EA) was used at process level (α) and plant level (β) while a cradle-to-gate Exergetic Life Cycle Assessment (ELCA) was conducted at the overall industrial level (γ) by means of the CEENE method (Cumulative Exergy Extraction from the Natural Environment). Life cycle stages taken into account are Active Pharmaceutical Ingredient (API) production, Drug Product (DP) production and Packaging. At process level (α), the total resource extraction for the manufacturing of one daily dose of PREZISTA^® (800 mg tablet) amounted up to 0.44 MJ_ex at the smallest scale (WG1) while this amount proved to be reduced by 58%, 79% and 83% at WG5, WG30 and WG240 respectively. Expanding the boundaries to the overall industrial level (γ) reveals that the main resource demand is at the production of the Active Pharmaceutical Ingredient (API), excipients, packaging materials and cleaning media used in DP production. At the largest scale (WG240) the use of cleaning media during DP production contributes considerably less to the total resource extraction. Overall, the effect of scale-up and learning on resource consumption during DP production showed to possess a power-law experience curve y = 2.40 * x^−0.57 when shifting from WG1 (smallest lab scale) to WG240 (industrial manufacturing). Tablet dosage (2× 400 mg versus 1× 800 mg) did not significantly affect the absolute environmental burden. However, the relative contribution of resource categories did change due to the different production technology. It could be concluded that in meeting social and economic demands by launching the PREZISTA^® 800 mg tablet, no trade-off in environmental burden occurred. On the long term, future research should strive to take into account R&D processes and all services related to pipeline activities taking place prior to market launch and eventually to allocate impacts to the final product.     

Water saving effect on integrated water resource management

This study proposes an improved integrated water resource management (IWRM), in which water conservation was analyzed for the entire water use process. A multi-objective optimization method was applied to optimize the IWRM, which investigated the reduction of freshwater consumption and the total water supply cost. Customer's preference for saving water and an end use analysis (EUA) was applied in the water conservation analysis. Taking Tianjin as the study area, a reduction in customer's economic pressure (EP) was utilized to evaluate the degree of the customer's preference for saving water. The results revealed that agriculture had a greater preference for saving water than other sectors, where as the public had the weakest motivation for saving water. Improving the transportation method could contribute 62.1% of the total water savings in the agriculture sector. The optimization of the IWRM demonstrated that the local freshwater savings would be 21.5%, and the total cost for water supplies would decrease by 13%. However, a government subsidy of 87.5 million Yuan would be needed. Additionally, by analyzing the change in the amount of water savings affected by water price, the appropriate water price increase range was suggested to be 1.5–1.7 times the original price.     

Material flow analysis of lubricating oil use in California

Petroleum lubricating oils, used throughout the economy, are distinct among petroleum products in their capacity to be recovered and recycled at the end of their useful life. Used lubricating oil is regulated at the state and federal level because of concerns about environmental impacts arising from improper disposal, although rates of recovery are not known. We present a material flow analysis of lubricants through California's economy in the years 2007–2012. We introduce a novel technique for computing aggregate waste generation from a collection of hazardous waste manifest records, and apply it in order to determine a recovery rate for used oil and to estimate the quantity of oil managed informally in the state. The records also offer a detailed view of the fate of used oils after they are recovered. We find that around 62% of lubricants are recoverable at end of life, of which 70–80% is being recovered. This rate shows a slight downward trend. If the trend is accurate, measures should be taken to improve the performance of the used oil management system. Policy opportunities exist to reduce the quantity of oil managed informally through improving access to responsible used oil management methods. These include increasing the collection of used oil from industrial sources as well as “do it yourself” oil changes, expanding in-state reprocessing capacity, and promoting increased out-of-state reprocessing of used oil. Our methods introduce new possibilities to make use of direct observation in material flow analysis, potentially improving data availability and quality and increasing the relevance of material flow methods in policy applications.     

SO2长期吸入对大鼠肺组织基因表达谱的影响

采用Affymetrix的基因芯片(RAE230A)技术,研究了SO2长期动态吸入(14mg/m3,1h/d,共30d)后大鼠肺组织基因表达谱的改变.结果表明,与对照组(CK)相比,SO2长期吸入后大鼠肺组织表达上调的基因有173个,其中包括79个已知基因和94个新基因,而表达下调的基因有85个,其中包括46个已知基因和39个新基因.表明:(1)长期吸入SO2的大鼠肺基因表达谱与其CK相比,表达有差异的基因涉及到脂肪酸代谢、免疫、炎症、氧化应激、原癌基因、肿瘤抑制基因和细胞外基质等,表明低剂量长期吸入SO2在体内的机理非常复杂;(2)SO2高剂量短期吸入与低剂量长期吸入后,大鼠肺组织基因表达谱的改变很不一致,表明二者在体内的作用机理不同;(3)SO2可引起多种基因的表达发生改变,这意味着多种基因的表达是易变的、不稳定的,在肺组织中可能存在着SO2诱发的表达不稳定型基因组.表1参19