Are pharmaceuticals more harmful than other pollutants to aquatic invertebrate species: a hypothesis tested using multi-biomarker and multi-species responses in field collected and transplanted organisms

The aim of this study was to test if pharmaceuticals could explain observed responses of field collected and transplanted invertebrate species (Hydropsyche exocellata, Echinogammarus longisetosus, and Daphnia magna). The study was performed in the middle and lower course of Llobregat river basin, which is affected by pharmaceuticals and other pollutants coming from sewage treated effluents. Up to 10 different endpoints including enzyme activities related with detoxication mechanisms (i.e. glutathione S transferase, catalase, esterases), the oxidative stress damage marker (lipid peroxidation), and individual responses (mortality, post-exposure feeding rates) were assessed. Biological responses were complemented with a detailed chemical analysis of metals, detergents, pesticides, pharmaceuticals and other general water quality variables to allow identifying causal abiotic factors. Estimated hazard indexes of measured pollutants indicated that pesticides and metals accounted for most of the predicted toxicity (>95%) in the most contaminated site and that the predicted toxicity of pharmaceuticals was marginal (<5%). The three species showed a clear impact across the studied gradient indicated by higher levels of feeding inhibition and of mortality towards lower reaches. Specific responses such as inhibition of cholinesterase activities were closely related to high and presumable toxic levels of diazinon, whereas unspecific responses such as enhanced levels of antioxidant defensive mechanism and of lipid peroxidation levels were associated with most pollutant classes as well as with high and presumable toxic levels of salt and ammonia. These results indicate that pesticides, salinity, ammonia probably had greater effects on the studied species than pharmaceuticals.     

The occurrence of illicit and therapeutic pharmaceuticals in wastewater effluent and surface waters in Nebraska

The occurrence and estimated concentration of twenty illicit and therapeutic pharmaceuticals and metabolites in surface waters influenced by wastewater treatment plant (WWTP) discharge and in wastewater effluents in Nebraska were determined using Polar Organic Chemical Integrative Samplers (POCIS). Samplers were installed in rivers upstream and downstream of treated WWTP discharge at four sites and in a discharge canal at a fifth location. Based on differences in estimated concentrations determined from pharmaceuticals recovered from POCIS, WWTP effluent was found to be a significant source of pharmaceutical loading to the receiving waters. Effluents from WWTPs with trickling filters or trickling filters in parallel with activated sludge resulted in the highest observed in-stream pharmaceutical concentrations. Azithromycin, caffeine, 1,7-dimethylzanthine, carbamazepine, cotinine, DEET, diphenhydramine, and sulfamethazine were detected at all locations. Methamphetamine, an illicit pharmaceutical, was detected at all but one of the sampling locations, representing only the second report of methamphetamine detected in WWTP effluent and in streams impacted by WWTP effluent.     

Human-caused wildfire risk rating for prevention planning in Spain

This paper identifies human factors associated with high forest fire risk in Spain and analyses the spatial distribution of fire occurrence in the country. The spatial units were 6,066 municipalities of the Spanish peninsular territory and Balearic Islands. The study covered a 13-year series of fire occurrence data. One hundred and eight variables were generated and input to a dedicated Geographic Information System (GIS) to model different factors related to fire ignition. After exploratory analysis, 29 were selected to build a predictive model of human fire ignition using logistic regression analysis. The binary model estimated the probability of high or low occurrence of forest fires, as defined by an ignition danger index that is currently used by the Spanish forest service (number of fires divided by forest area in each municipality). Thirteen explanatory variables were identified by the model. They were related to agricultural landscape fragmentation, agricultural abandonment and development processes. The prediction agreement found between the model binary outputs and the historical fire data was 85.3% for the model building dataset (60% of municipalities). A slightly lower predictive power (76.2%) was found for the validation data (the remaining 40%). The probabilistic output of the logistic was significantly related to the raw ignition index (Spearman correlation of 0.710) used by the Spanish Forest Service. Therefore, the model can be considered a good predictor of human-caused fire risk, aiding spatial decisions related to prevention planning in Spanish municipalities.     

大空间建筑火灾下钢索的力学反应参数分析

钢索在大空间建筑火灾升温条件下的力学反应是评价索网结构抗火性能的关键依据。基于非线性有限元方法,建立了钢索在高温下的力学分析模型,模拟了大空间建筑火灾升温历程中钢索力学反应全过程,用参数分析方法得到影响钢索在火灾升温历程中力学反应的关键因素。结果表明:在大空间建筑火灾升温历程中,钢索的水平张力呈下降的趋势;随着钢索的预应力比增加、温度场非均匀性的增强和跨度的增加,其水平张力下降速率增大;荷载比的增加对水平张力下降速率影响较小。上述结论与钢索水平张力的解析解一致,可为索网结构抗火性能分析提供参考。     

制药废水生化处理后的深度处理方法比较研究

随着制药废水排放标准的提高,对制药废水进行深度处理是实现其达标排放的有效途径之一。试验比较了絮凝、高级氧化、吸附、超滤等方法对生化处理后的高浓度制药废水深度处理效果,结果表明:4种方法中,只有活性炭吸附对废水COD、浊度、色度、氨氮等都具有较好的去除效果,COD去除率最高能达到62%,可实现达标排放。     

Synthesized magnetic nanoparticles coated zeolite for the adsorption of pharmaceutical compounds from aqueous solution using batch and column studies

The contamination of fresh water with pharmaceutical and personal care products (PPCPs) has risen during the last few years. The adsorption of some PPCPs namely, Diclofenac-Na, Naproxen, Gemfibrozil and Ibuprofen from aqueous solution has been studied, magnetic nanoparticles coated zeolite (MNCZ) has been used as the adsorbent. Batch adsorption experiment was conducted to study the influences of different adsorption parameters such as contact time, solution pH and PPCPs concentrations in order to optimize the reaction conditions. The removal was favored at low pH values. Thus, as pH turns from acidic to basic conditions these compounds were less efficiently removed. The initial concentration does not appear to exert a noticeable effect on the removal efficiency of the studied PPCPs at low concentrations, but it showed less removal efficiency during high concentration of PPCPs especially for Ibuprofen. The removal of Diclofenac-Na was independent on time, while the contact time was of significant effect on the adsorption of Naproxen, Gemfibrozil and Ibuprofen even though these compounds were removed up to 95% during 10 min using MNCZ. From the isotherm adsorption study, the adsorption of PPCPs studied on MNCZ was best fitted with Freundlich isotherm equation. Pseudo-second order model providing the best fit model with the experimental data. Column adsorption study was conducted to compare the removal efficiency of MNCZ with other processes used at drinking water treatment plants (DWTPs), MNCZ showed high removal efficiency (>99%) than other used processes at DWTPs.     

Ecotoxicological risk assessment linked to the discharge by hospitals of bio-accumulative pharmaceuticals into aquatic media: The case of mitotane

The release of hospital wastewater into the urban sewer networks contributes to the general contamination of aquatic media by pharmaceutical residues. These residues include bio-accumulative pharmaceuticals that lead to increased risk for ecosystems because they can concentrate in organisms and food chains, and therefore reach toxic levels. In order to assess the ecotoxicological risks linked to this particular category of residues, we have developed a specific method, by combining a theoretical calculation of pollutant concentrations in organisms to estimate Body Residue (BR), and ecotoxicity biomarkers in fish cell lines, enabling the calculation of a Critical Body Residue (CBR). This method finally results in the calculation of a specific risk quotient (Qb = BR/CBR), characterizing the risk linked to this type of pollutant. This method was applied to mitotane, a bio-accumulative pharmaceutical typically found in hospital wastewater, in the framework of an exposure scenario corresponding to the discharge of all the hospital wastewaters into the Rhone River which flows through the city of Lyon, France. This approach leads to risk quotients (Qb and Qbg) much higher than those found with the classical approach, i.e. Q = PEC/PNEC (Predictive Environmental Concentration/Predictive Non Effect Concentration) = 0.0006. This difference in the appreciation of risk is important when using cytotoxicity as the criterion for measuring the toxicity of mitotane (Qb = 0.056) and it is even greater when the criterion used is genotoxicity (Qbg = 6.8). This study must be now consolidated by taking the biomagnification of the pharmaceuticals into consideration.     

Decision analysis on fire safety design based on evaluating building fire risk to life

This study presents a framework of decision analysis on fire safety design alternatives based on evaluating building fire risk to life. A probabilistic risk assessment method for occupant life is presented with consideration of some uncertainties of evacuation process and fire development at first. For occupant evacuation time assessment, occupant pre-movement time is characterized by normal distribution. For onset time to untenable conditions assessment, its uncertainty is considered as probability distribution according to the range of design fires. Based on event tree technique, probable fire scenarios are analyzed with consideration of the effect of fire protection systems, employees extinguishing, etc. It is difficult to make a precise assessment on probability and consequence of every fire scenario, but their lower bound and upper bound can be achieved based on statistical data. Therefore, Supersoft Decision Theory [Malmnäs, P.E., 1995. Methods of Evaluation in Supersoft Decision Theory. Department of Philosophy, Stockholm University, 365 Stockholm; Johansson, H., Malmnäs, P.E., 2000. Application of supersoft decision theory in fire risk assessment. Journal of Fire Protection Engineering 14, 55–84] that allows decision maker to utilize vague statement is utilized to integrate with risk assessment to make decision on different fire safety design alternatives. To express how to make decision on different fire safety design alternatives based on evaluating building fire risk to life, two hypothetical fire safety design alternatives for a commercial building are presented.     

Metal hydride fires and fire suppression agents

Most metal hydrides are pyrophoric and water-reactive. Summaries of metal hydride fire incidents are presented to illustrate ignition scenarios, threats to personnel and equipment, and fire suppression experiences. Met-L-X™, a sodium chloride-based, certified, Class D fire suppression agent, has successfully extinguished some metal hydride fires by coating the hydride and excluding air access. However, the still hot hydride is prone to re-ignition upon surface disturbance, such as may be necessary during disposal. Previously reported testing of various Class D agents and moist sand for sodium hydride fires is reviewed here along with certification and ad hoc testing of existing Class D agents and recent testing of a new candidate Class D agent. Hydride explosibility testing is also briefly summarized. Additional fire and explosibility tests, as well as suppression agent reactivity evaluations, are recommended.     

中国森林火灾周期振荡的小波分析

小波分析具有自适应性和数学显微镜性质,能将交织在一起的不同频率成分组成的复杂的时间序列分解成频率不相同的子序列.本文采用Matlab 6.5软件对1950～2002年中国林火统计资料进行小波分析,采用的小波是Daubechies 10.结果表明,1950～2000年森林火灾受害森林面积总体上呈下降趋势,1995以后受害森林面积基本控制在比较低的水平,年际间变化不大.10年和30年尺度上的变化反应出气候和植被变化对森林火灾的影响,可燃物的变化表现出近10年周期的波动性.1950～2000年中国森林火灾次数整体上是下降的,森林火灾发生次数减少的主要原因是我国对森林火灾的预防、监测和扑救能力都得到显著提高,特别是对人为火源进行了严格控制,近年来林火发生次数保持在相对低的水平.