The role of toxicology in the evaluation of new agrochemicals

Abstract

The use of agrochemicals like crop protecting agents, veterinary disinfectants, and wood preservatives may result in (un)intentional exposure of the environment, animals and man. This paper deals with current testing strategies to assess the potential health risks for humans exposed to these chemicals during production or application or via consumption of foods containing pesticide residues.

Principles and procedures for safety assessment of pesticide residues in food as developed by WHO/FAO are described. Different types of toxicity studies in mammalian test animal species are discussed and a strategy is outlined in order to characterize the toxicity profile of a compound and the relationship between applied doses and adverse effects. Safety testing of agrochemicals should be carried out in relation to its intended use, and in particular attention will be paid to toxicity testing of residues of pesticides in food. Extrapolation of results from animal studies to humans and the use of safety factors is discussed.

Besides the use of animal protocol studies for safety testing of agrochemicals, the potential use of in‐vitro models derived from organs and tissues of animals is discussed. Data on the in‐vitro metabolism of thiabendazole, aldicarb and alachlor are discussed in order to demonstrate that such data may complement or partly substitute whole animal experimentation.

Principles and procedures for safety testing of residues of agrochemicals in food as applied during the last three decades, constitute a ‘safety‐first’ approach, providing sufficient safety margins for the consumer of foods which may contain low levels of residues of agrochemicals.     

Safety testing of pesticides and methods of evaluating human exposure in the field

Abstract

The importance of field surveys to provide data on acute pesticide hazards is discussed. The types of questions which small field surveys of pesticide exposure should answer are presented. In addition to protective clothing, the value of distance, time, and personal hygiene in reducing exposure are considered. Finally, the importance of an adequate data base for the development of protocols and guidelines for public protection is discussed.     

试用“三论”探索我国安全生产宏观管理模式

本文试用系统论、控制论和信息论的观点探索我国安全生产宏管理模式。文中主要分析了生产安全系统的内涵;行业生产安全系统的内涵;以及生产安全系统的宏观控制的内涵。并指出了行业生产安全系统是生产安全系统的主体控制系统,劳动安全监察系统是生产安全系统的强化控制系统。     

安全科学技术也是第一生产力(第一部份)

本文提出安全科学技术也是第一生产力的观点。文中简析了科学、技术和科学技术的内涵及其相互关系;研究了科学技术与生产力的关系;阐述安全科学技术也是第一生产力:探讨了发展高科技与安全科学技术的关系;安全科学技术发展中应注意的问题。     

关于现代中国安全生产管理体系研究：管理、法规、文化

对我国安全生产管理的宏观及微观形势分析，论证了安全生产与国民经济的关系。特别指出从根本上遏制新的事故高峰，关键应强化“大安全观”的安全生产管理体系建设与实践。研究向市场经济转换过程中的中国安全减灾业的发展及管理思路，重点探索了体系化管理、安全文化及安全生产法的主题。     

DOMESTIC WASTEWATER TREATMENT BY PEATLANDS IN A NORTHERN CLIMATE: A WATER QUALITY STUDY1

ABSTRACT: The use of peatlands as the main form of wastewater treatment in a northern climate was studied for the James Bay Energy Society. The Fontanges campsite (70° 17′ 30″ W; 54° 34′ 00″ N) was chosen as the study site. In less than 1.5 km from the point of discharge BOD₅, COD, total hardness, inorganic carbon, orthophosphates, total phosphorus, ammonia and total nitrogen were reduced by at least 90 percent. The peatland treatment system studied is divided into four components, each having a specific function. The first part combines the action of microorganisms and adsorption on peat, thus reducing the organic content while increasing the inorganic constituents. The second part uses peat to adsorb the inorganic elements already present in the wastewater and those produced in the first part of the system. The third component acts as an aerator, increasing the dissolved oxygen and decreasing the BOD₅ levels of the water. The fourth part removes most of the remaining nutrients, thus acting like a tertiary treatment. Overall, peatlands seemed to be effective in treating domestic settled wastewater in a cold climate.     

风险学与安全减灾─—从参加“风险科学与管理”国际研讨会谈起

阐述建立风险学的重要性，探讨了开展安全减灾风险评价与管理的关键问题。概要介绍国内外风险水平的表征、识别方法及指标体系，并提出风险管理的基本原则。引入风险地图、危机管理、风险数学、应急与预警等现代概念及方法，基本反映了在瑞典召开的“新区开发中的风险科学与管理”国际会议的内容。     

广深准高速铁路安全管理模式探讨

广深准高速铁路的开通运营，以及广深铁路公司股份制改造，从客观上要求改革与优化铁路安全管理体制，建工新的铁路安全管理模式。本文构造了广深铁路安全管理模式，满足国家确定的“企业负责，行业管理，国家监察，群众监督”的安全工作体制要求，引入风险管理，实行事故保险，提出应该以安全文化作为新模式的软件，优化新的安全管理体制。     

建筑安全技术的历史,现状与发展

从人与自然的相互关系，讨论了在发展生产的必须重视保护人类自身和生存环境，就我国建筑安全技术的现状，论述了发展科学技术是改善建筑安全技术最根本的途径，提出了当前普遍存在的安全技术在问题和需要完善的建筑施工安全法规。     

试论起重机械安全检查标准

根据起重机械可能发生的事故和特点，制定具体的检查标准，对于施工现场安全管理工作具有比较实际的指导意义。本文重点对起重机械特别是塔吊的安全检查，探讨了常规、特殊检查标准；年度、月度、日检查标准；塔吊的金属结构、机械、电气、液压系统等方面的检查标准。并介绍了简单的检查方法。