SO2 inhalation causes synaptic injury in rat hippocampus via its derivatives in vivo

SO₂ remains a common air pollutant, almost half of the world’s population uses coal and biomass fuels for domestic energy. Limited evidence suggests that exposure to SO₂ may be associated with neurotoxicity and increased risk of hospitalization and mortality of many brain disorders. However, our understanding of the mechanisms by which SO₂ causes harmful insults on neurons remains elusive. To explore the molecular mechanism of SO₂-induced neurotoxic effects in hippocampal neurons, we evaluated the synaptic plasticity in rat hippocampus after exposure to SO₂ at various concentrations (3.5 and 7 mg m⁻³, 6 h d⁻¹, for 90 d) in vivo, and in primary cultured hippocampal neurons (DIV7 and DIV14) after the treatment of SO₂ derivatives in vitro. The results showed that SYP, PSD-95, NR-2B, p-ERK1/2 and p-CREB were consistently inhibited by SO₂/SO₂ derivatives in more mature hippocampal neurons in vivo and in vitro, while the effects were opposite in young hippocampal neurons. Our results indicated that in young neurons, SO₂ exposure produced neuronal insult is similar to ischemic injury; while in more mature neurons, SO₂ exposure induced synaptic dysfunctions might participate in cognitive impairment. The results implied that SO₂ inhalation could cause different neuronal injury during brain development, and suggested that the molecular mechanisms might be involved in the changes of synaptic plasticity.     

提高交通安全——实现智能汽车的研究

主要介绍了通过智能汽车的研究 ,提高城市交通安全的必要性 ;综述了发达国家关于智能汽车研究的现状与趋势 ,并通过国外智能汽车发展的趋势 ;进一步论证智能汽车的研究是汽车工业发展的方向 ,也是提高交通安全的重要手段之一。此外 ,论文提出利用模式识别技术的智能汽车的结构框架 ;指出神经网络方法应用与模式识别技术结合的优势。最后 ,论文在阐述我国需要发展智能汽车的同时 ,提出应结合中国国情相应研究相关理论 ,为今后的实施奠定基础的近期目标 ,并提出展望     

1900个乡镇工业的工伤职业病医疗保障现状分析

在调查的１９００个乡镇工业企业中,有９．３％ 的企业对职工工伤职业病没有任何保障,其中尤其是个体联户所办企业则高达１５％ 。按行业进行分析,最易发生工伤职业病的各种矿山采选业、建材生产业,能给予报销医疗费的企业占７８．５％ ,部分给予报销的企业占１０．２％ ,不予报销企业占１１．３％ 。从保障程度看,能给予全部报销医疗费的企业仍以乡办企业为最高（９３．２％ ）,其次为村办企业（９０．２％ ）和个体联户所办企业（８８．５％ ）     

对灾害研究中几个问题的思考

对灾害研究中有关的几个问题进行了探讨。认为： 灾害学是最重要的自然社会科学; 人文灾害比自然灾害更具毁灭性; 研究人文灾害中的公路交通事故、核战争问题、人口问题、环境污染问题等具有重要的现实意义和深远的历史意义。     

Using state administrative data to study nonfatal worker injuries: challenges and opportunities

PROBLEM: Administrative data from states have the potential to capture broader representation of worker injury, facilitating examination of trends, correlates, and patterns. While many states use their workers' compensation (WC) data to document frequency and type of injury, few conduct in-depth examinations of patterns of injury and other etiologies. Administrative data are generally an untapped resource. METHOD: Comparisons are made among four state databases used in a study linking worker injuries and patient outcomes in hospitals and nursing homes. RESULTS: Worker injury data varies in terms of inclusion criteria, variables, and coding schemes used. Linkages to organizational level characteristics can be difficult. CONCLUSIONS: Despite limitations, data can be used to study injury patterns and etiologies. Users must be knowledgeable and recognize how database characteristics may influence results.     

基于安全流变理论的交通系统事故过程分析

运用事物的安全流变规律分析系统的运行过程 ,指出系统的运行过程符合安全流变规律。通过对交通系统中的不安全因素扰动的分析 ,揭示了交通系统的安全流变特征 ;对传统的事故定义进行了拓展 ,将事故隐患纳入了事故的发展过程 ;提出了交通系统事故安全流变分析方法 ;最后通过一个具体的案例分析了系统事故的安全流变过程。     

Adolescent driver risk taking and driver education: evidence of a mobility bias in public policymaking

PROBLEM: Road traffic injury is the leading cause of death among adolescents in high-income countries. Researchers attribute this threat to driver risk taking, which driver education (DE) attempts to reduce. Many North American authorities grant DE graduates earlier access to unsupervised driving despite no evidence of this being a safety benefit. This theoretical article examines risk taking and DE in relation to an apparent mobility bias (MB) in policymaking. METHOD: The MB is defined, the history and sources of driver risk taking are examined, and the failure of DE to reduce collision risk is analyzed in relation to a potential MB in licensing policies. DISCUSSION: The author argues that DE's failure to reduce adolescent collision risk is associated with a MB that has produced insufficient research into DE programs and that influences public policymakers to grant earlier licensure to DE graduates. Recommendations are made regarding future research on DE and risk taking, coordinated improvements to DE and driver licensing, and a plan to reduce collision risk by encouraging parental supervision after adolescent licensure. IMPACT ON INDUSTRY: Research on adolescent driver risk taking would have direct applications in DE curricula development, driver's license evaluation criteria, graduated licensing (GDL) policies, as well as other aspects of human factor research into the crash-risk problem.     

New Zealand drivers study: developing a methodology for conducting a follow-up study of newly licensed drivers

PROBLEM: In recent years, there has been a significant reduction in traffic crash injury among young people, but they continue to be overrepresented in the traffic crash statistics. To improve this situation, sound scientific evidence is needed to develop effective policies and programs. METHOD: The aim of the proposed study is to provide this evidence by examining early driving and driving-related experiences of newly licensed drivers as they progress through the learner-, restricted-, and full-license stages of the graduated licensing system and to determine the impact of these experiences on subsequent negative traffic-related outcomes (risky driving behavior, injury traffic crashes, noninjury traffic crashes, infringements, convictions). Given the size and complexity of the proposed study, a comprehensive pilot study was undertaken to determine the feasibility of conducting a New Zealand-wide cohort study of newly licensed drivers. RESULTS: This article describes the pilot study process and the methodology that has been developed for the New Zealand-wide study.     

高速公路交通事故分析及预防对策研究

利用济青高速公路 1998～ 1999年发生的 10 85起交通事故数据 ,在资料收集、处理和统计分析的基础上 ,对影响高速公路交通事故的人、车辆、道路环境、天气和交通量等主要因素进行了分析 ,并与国外的统计结果进行对比研究 ,预测出随着高速公路交通量的增长 ,事故率将会增加。此外 ,笔者针对影响高速公路事故因素提出了主动性、被动性预防对策 ,这些对策的实施将会减少高速公路事故的发生     

Distractions and the risk of car crash injury: the effect of drivers' age

PROBLEM: Motor-vehicle accidents are one of the major causes of injury in most motorized countries. Driver distractions have been suggested as a contributor to traffic accidents. Moreover, age of the driver seems to have a role in the relationship between distractions and car crashes. But very few studies have investigated the effect of driver's age on this relationship. This exploratory study investigated the association between distractions, both inside and outside the vehicle, and the increased risk of car crash injury among drivers across different ages. METHOD: This study used a case series design to analyze data routinely collected by the NSW police in Australia. A special focus of this study was on how drivers' age affects the risk of car crash injury, which was determined by using a well-documented risk estimation methodology. RESULTS: The results obtained indicated that drivers of all ages, on the whole, are more susceptible to distractions inside the vehicle than distractions coming from outside. Age was shown to affect the relationship between in-vehicle distraction and the risk of car crash injury. A separate analysis was also conducted on hand-held phone usage while driving with results supplementing previous findings reported in the literature. IMPACT TO INDUSTRY: Safety strategies to countermeasure in-vehicle distractions have been suggested and discussed.