Genetic toxicology of metal compounds: An examination of appropriate cellular models †

Bacterial systems have not had success predicting metal carcinogenicity. Hypotheses explaining this failure are examined. Using a broad genetic endpoint, λ prophage induction, under sub‐toxic growing conditions, genotoxicity is seen for compounds of chromium, manganese, lead, molybdenum and tungsten. Copper, manganese, arsenic and molybdenum compounds enhanced UV mutagenesis in E. coli WP2.

The toxicity of metal compounds to cultured mammalian cells correlates well with rat oral LD₅₀ values. Whereas insolubility can present problems in bacterial studies, concentrations of metal compounds toxic to mammalian cells can be determined even in the presence of precipitate, and sometimes [Pb(NO₃)₂, BaCl₂ and BeCl₂] occurs only in its presence. PbS and MnS, which are insoluble, are much more toxic than the more soluble compounds Pb(NO₃)₂ and MnCl₂. These results demonstrate the importance of cellular phagocytosis of insoluble metal compounds as a factor in studying the toxicity and genotoxicity of metal compounds.     

信息化在海外油气项目HSE管理中的应用

伴随着中国石油企业走出去的步伐不断加快,海外油气项目的规模迅速扩大,相较于国内而言,海外油气项目面临的环境更加复杂,HSE管理难度更大。探索一种科学、高效并且符合现代化管理要求的先进管理手段,与企业的HSE管理有机融合,从而确保企业HSE管理体系良好运行,对于企业具有重要意义。中国某石油企业海外项目（A公司）在此方面进行了大量、有益的实践,其将自身的信息管理系统与HSE体系有机融合,从而实现了HSE管理的信息化。选取A公司的事故预防应急系统作重点介绍,将A公司的事故预防管理与传统事故预防管理进行对比,同时将A公司的应急管理与传统应急管理进行对比,最后提出了针对HSE管理信息化的思考,以期对石油企业海外项目的HSE管理提供帮助。     

地震应急期关键时间阶段划分研究

在研究我国地震应急救援相关法律法规、预案,以及汶川、玉树、盈江、彝良和海地、东日本等国内外地震应急救援案例的基础上,将地震应急期划分成应急启动、紧急救援、过渡性安置等3个阶段,并对各阶段的持续时间、主要工作及其先后次序进行了梳理.在实际抗震救灾工作中,这3个阶段不是互不相干、相互独立的,而是存在一定的时间相关性.这就需要指挥者对不同阶段的重点工作优先考虑,同时兼顾各项相关工作,保证抗震救灾工作的顺利进行.     

基于解释结构模型的城乡结合部突发事件触发源研究

基于解释结构模型对城乡结合部突发事件触发因素进行分析,通过建立城乡结合部突发事件触发因素的关系结构模型,分析得到触发突发事件的表层影响因素、中层间接影响因素和深层根本影响因素。结果表明:人口因素是触发突发事件的深层根本因素,社会文化因素以及国家制度政策因素是中层影响因素,而土地因素、经济发展因素以及生态环境因素等是触发城乡结合部突发事件的表层因素。掌握这些因素,这在很大程度上会避免城乡结合部突发事件的发生,对政府的应急管理工作具有一定的参考价值。     

突发事件应急预案的评估研究

对突发事件应急预案进行有效地评估,是提高应急预案实效性,保证预案能够发挥其理想效果的关键环节。目前国内应急预案的评估多为模板式评估研究,评估的依据和内容有待完善,文章探究对照法在应急预案评估中的应用,以提升应急准备能力为目的,重点对预案的充分性、可行性、完整性、可接受性、符合性这5方面进行评估,提出预案修订建议,并以真实应急预案为例具体描述评估过程。     

基于层次分析与模糊综合评价的事故应急预案评估

对应急预案的评估是应急救援的重要组成部分。为评估企业安全生产事故应急预案的优劣,提出了一种层析分析和模糊综合评价相结合的方法。按照科学性、完整性等原则构建了一个包含5个一级要素及28个二级要素的企业安全生产事故应急预案评估指标体系。通过所建立的指标体系对某企业突发安全事故应急预案进行完整性和有效性评估。该研究对企业安全生产事故应急预案的编制和改进、定量评价及评估的软件化具有一定的指导意义。     

Oxidative and genotoxic effects of bisphenol A on primary gill cell culture of Lake Van Fish (Alburnus tarichi Güldenstädt, 1814)

Lake Van is the largest lake in Turkey. The lake limits lifespan due to its high pH and brackish water. For this reason, only a single species of fish (Van Fish) is living in the lake that has been adapted to these conditions. In the present study, we investigated the total oxidant status (TOS), total antioxidant status (TAS), malondialdehyde (MDA) level and DNA damage effect of bisphenol A (BPA) (10^?7, 10^?6 and 10^?5?M) on primary gill cell culture of Van Fish for 24 and 48?h of incubation periods. TAS levels were not changed when compared to those of the control group, but TOS levels were decreased in both 24 and 48?h. The MDA level increased only at the highest concentration (10^?5) at the end of 12 and 24?h (p?.05). DNA damage increased only at the 10^?5?M concentration after 48?h. At the end of the experiment, BPA exposure caused lipid peroxidation and genotoxic effect. These results indicate that high levels of BPA exposure induced oxidative stress and DNA damage by time- and concentration-dependent fashion in the gill cell culture of Van Fish. Gill cell culture is a useful model for the rapid identification of the harmful effects of chemicals in the aquatic environment.     

The role of Confucianism in South Korea's emergency management system

Numerous Western researchers have examined the influence of Confucianism on development in Asia, but almost no South Korean researchers have studied the topic in regard to emergency management in their own country. This study begins by considering Confucianism as a social culture. Next, it goes on to evaluate its role in South Korea's emergency management system, contributing, ultimately, to efficiencies in emergency management. Drawing on a literature review and a case study, the paper assesses the double‐ and single‐faced approaches, using four major Confucian components: destiny; family; ritual; and relation. The double‐faced approach includes the positive and negative aspects of emergency management, whereas the single‐faced approach incorporates only its positive aspects. This paper provides, for the first time, a systematic analysis of the relationship between Confucianism and emergency management in South Korea. Its key finding is that the double‐faced approach needs to be transformed into a single‐faced approach through active facilitation of behavioural change.     

高校安全文化建设现状及对策研究——以L大学为例

为了改善L大学安全状况,提高L大学安全文化建设水平,采用文献对比分析法研究高校安全文化定义及其理论实质,从狭义的角度提出高校安全文化是高校管理的一系列安全理念,具体化为32条高校安全文化核心元素。以L大学为研究样本,定性分析其安全文化建设内容;编制高校安全文化定量测量量表,对其安全文化建设水平进行定量测量。评价结果表明L大学安全文化建设存在缺欠,提出了实用性对策措施和建议。