洪泽湖水产品中渔药残留量调查

通过对洪泽湖水产品中部分渔药残留的检测和研究,对洪泽湖水产品的渔药残留量以及相关的水质情况有了初步掌握。结果表明,洪泽湖水产品中渔药残留量总体情况较好,但在网箱和围网养殖区域中,土霉素和磺胺类两种渔药在水体中存在量较大。     

高危及重要客户供用电安全管理信息平台建设

针对电力系统高危及重要客户供用电的安全、规范化管理,结合实际情况,参考国网公司典型经验,进行了国网宁夏电力公司客户供用电安全管理信息平台开发建设,实现高危及重要客户供用电安全全过程管理。应用结果表明:客户供用电安全管理信息平台全面提高了公司客户安全管理水平,对构建安全和谐的供用电环境起到了积极的促进作用。     

传粉蜜蜂介导的细菌耐药性传播及其生态与健康风险

目前,抗菌药物的滥用造成了临床和环境中普遍存在的细菌耐药性问题,而细菌耐药性在环境中不断富集和传播扩散会通过食物网对生态安全及人体健康构成威胁。蜜蜂作为最重要的传粉昆虫,在世界各地广泛分布。然而,蜜蜂近年来频繁暴露于抗生素、杀虫剂和杀螨剂等药物,而野外杀虫剂的大量使用被认为是导致世界各地蜜蜂种群数量下降的关键因素。蜜蜂传花授粉的生物学特性使得蜂群与周围环境之间发生频繁的交流,可能导致蜜蜂传粉过程中蜂群与周围环境的交叉污染并发生细菌耐药性的传递。因此,蜜蜂可能成为生态系统中细菌耐药性传播的潜在“帮凶”。传粉蜜蜂介导下的细菌耐药性传播也将对蜂群健康、食品安全乃至生态系统安全构成威胁。本文综合国内外相关研究进展,系统分析了环境污染物暴露对蜜蜂以及蜜蜂肠道耐药基因组的潜在影响,并详细阐述了传粉蜜蜂介导下的细菌耐药性的传播,总结了蜜蜂主要通过蜜蜂-蜜蜂、蜜蜂-植物以及蜜蜂-环境的途径促进细菌耐药性的传播。最后,探讨了蜜蜂介导的细菌耐药性传播对蜂群健康、生态环境以及人体健康的潜在影响。     

Comparison of epidemiology and injury profile between vulnerable road users and motor vehicle occupants in road traffic fatalities

Objective: Road traffic injuries (RTIs) are a major global health issue causing a global burden of mortality and morbidity. Half of all fatalities on the world’s roads are vulnerable road users (VRUs). The targeted intervention strategies based on fatality analysis focusing on VRUs can effectively contribute to reducing RTIs. This study aimed to compare VRUs and motor vehicle occupants (MVOs) in terms of epidemiology and injury profile.

Methods: We utilized a nationwide, prospective database of RTI-related mortality cases for patients who visited 23 emergency departments between January 2011 and December 2015. All fatalities due to RTIs in the prehospital phase or in-hospital were eligible, excluding patients with unknown mode of transport and those admitted to general wards. The primary and secondary outcomes were fracture injuries and visceral injuries diagnosed using the International Classification of Diseases, Tenth Revision (ICD-10). We compared fracture injuries between VRUs and MVOs using Abbreviated Injury Scale (AIS) 2? and 2+ classification.

Results: Among a total 3,694 road traffic fatalities (RTFs), 43.3% were pedestrians, followed by MVOs (27.0%), motorcyclists (18.9), bicyclists (6.6%), and agricultural vehicle users (4.2%). The elderly (>60 years old) accounted for 54.9% of VRU fatalities. RTFs occurred most frequently in the autumn and the VRU group and the MVO group showed significant differences in weekly and diurnal variation in RTFs. The injury severities (AIS 2+) of the head, neck, and thorax were significantly different between the 2 groups (P?Conclusions: Elderly pedestrians should be targeted for decreases in RTFs, and road traffic safety interventions for VRUs should be made based on the analysis of temporal epidemiology and injury profiles of RTFs.     

The role of drug and alcohol use and the risk of motor vehicle crashes in Shiraz,Iran, 2014: A case–crossover study

Background: Traffic accidents and traffic-related injuries and mortality have become a major public health concern in Iran. This study aimed to examine the role of drug and alcohol use in motor vehicle accidents in Iran.

Methods: This case–crossover study was conducted on 441 drivers who survived a road traffic crash and were taken to the emergency department of Shahid Rajaee trauma hospital in Shiraz, southern Iran. Data were collected using checklists that included demographic characteristics and drug and alcohol use prior to driving. Alcohol and drug use was identified through self-report, and cannabis, morphine, and methamphetamine urine tests were used to confirm drug abuse among drivers.

Results: In total 17.9% of drivers reported using drugs (cannabis, opium, or metamphetamine) and 8.84% of drivers reported consuming alcohol prior to the collision. The crude odds ratios (ORs) for having a crash for opium, cannabis, and metamphetamine were 1.94 (95% interval confidence [CI], 1.11–3.38), 2.37 (95% CI, 1.03–5.42), 5.5 (95% CI, 1.21–24.81), respectively, and for all drugs was 3.83 (95% CI, 2.28–6.43). The OR for alcohol was 3.5 (95% CI, 1.73–7.06) based on self-report.

Conclusion: Drug and alcohol use are increasing the risk of traffic crashes in Iran. Risk-reducing programs must be designed and implemented.     

水电工程高危作业风险影响因素的SEM模型

为探索水电工程高危作业的事故致因机理,耦联分析水电工程施工风险管理过程,从"施工企业影响"、"施工安全管理"、"施工人员行为"、"现场作业相关因素"等方面归纳总结水电工程施工事故风险要素及构成体系;在此基础上,通过问卷调查收集基础数据并定义研究变量属性,抽象风险与影响因素关系的概念模型,建立与检验高危作业风险的SEM模型;然后,以修正指数MI为判据,修正和优化SEM模型。研究结果表明:安全管理制度、教育培训、职业健康环境、个人决策能力对水电高危作业风险具有显著影响,是风险监管的重点,同时也启示风险管理者应深入贯彻"以人为本"的理念,加强"顶层制度设计"。     

人群拥挤踩踏事故的场所高危点统计与分析

本文首先对人群拥挤踩踏事故的发生场所进行了统计,通过对场所的特征分析,总结了学校、宗教场所、体育场所、街道、歌舞娱乐场所、地铁站、公园、大型商场等人群容易聚集场所的事故高危点。然后对楼梯、过道、坡面、桥梁、出入口、地下通道等高危点进行了详尽的分析,并对高危点的特点进行了总结,分析了高危点的危险度。本文的统计与分析结果能够为人群聚集活动的安全预案制定、高危点识别、安保人员设置等提供客观的参考。     

畜禽养殖场排放物病原微生物危险性调查

以粪大肠菌群和沙门菌为指标,采集江苏省内10家不同养殖类型畜禽养殖场的排放物及其周边水、土样共37个进行观察与计数,同时分析排放污水中大肠杆菌的耐药性以及禽畜排泄物对土壤和水体耐药细菌数的影响.结果表明:调查的10家养殖场中有9家粪便未经无害化处理直接排放到水体或施于农田,且排放物的粪大肠菌群数全部严重超标,沙门菌检出率达19%,施新鲜粪肥的土壤中粪大肠菌群数(MPN,最大可能数)在105 g-1以上,水体中分离出的大肠杆菌表现出多重耐药性,抗生素抗性细菌总数也远高于未施新鲜粪肥的土壤及水体.     

喹诺酮类典型抗生素对反硝化细菌的联合药敏试验研究

抗生素对反硝化过程有不同程度的影响,为快速了解喹诺酮类抗生素对水土环境中反硝化可能产生的影响,选取5种典型的喹诺酮类药物:左氧氟沙星(OFL)、盐酸洛美沙星(LOM)、环丙沙星(CIP)、恩诺沙星(ENR)、诺氟沙星(NOR)对反硝化细菌进行单一及联合药敏试验,探究抗生素单独使用和联用时对反硝化细菌的作用效果.本文首先...     

New insights into the characterization of the binding of tetracycline analogues with lysozyme: a biophysical study

Tetracycline (TC), chlortetracycline (CTC) and oxytetracycline (OTC) are the most common members of the widely used veterinary drug tetracyclines, the residue of which in the environment can enter human body, being potentially harmful. Lysozyme is a monomeric protein widely distributed in the nature including human beings, having many physiological and pharmaceutical functions. The aim of this study was to examine the interaction of lysozyme with the three tetracyclines (TC, CTC and OTC) through spectroscopic and molecular modeling methods. The experimental results revealed that all the three tetracyclines (TCs) can interact with lysozyme with one binding site to form TCs-lysozyme complex, mainly through electrostatic forces with the affinity order: CTC > TC > OTC. The binding of TCs can cause conformational and some microenvironmental changes of lysozyme. Furthermore, molecular docking was applied to define the specific binding sites, the results of which show that all the three TCs can bind into lysozyme cleft and interact with the key active-site residues Glu 35 or Asp 52, resulting in competitive inhibition of lysozyme activity. The accurate and full basic data in the work is beneficial to clarifying the binding mechanism of TCs with lysozyme in vivo.