碘代乙酸体外暴露诱导斑马鱼(Danio rerio)淋巴细胞内源性凋亡可能机理研究

以斑马鱼(Danio rerio)为试验生物,经淋巴细胞体外暴露试验,从细胞内源性凋亡角度,研究了饮用水消毒副产物—碘代乙酸诱导斑马鱼淋巴细胞损伤的致毒机理.结果表明,在碘代乙酸的环境浓度1μg·L-1下暴露24、36、48和96 h后,细胞凋亡率从对照组的3.52%分别增加到15.89%、22.47%、40.76%和52.13%,与对照组差异均为极显著(p0.01);线粒体膜电位分别较对照组下降了32.9%、50.1%、68.6%和81.5%,与对照组差异均为极显著(p0.01);细胞色素C的相对释放量分别增加了0.85、1.37、1.86和2.66倍,与对照组差异均为极显著(p0.01).暴露36、48和96 h后,Caspase-3酶活性分别增加了0.49、0.86和1.43倍,与对照组差异均为极显著(p0.01);Caspase-9酶活性分别增加了0.73、1.41和1.88倍,与对照组差异均为极显著(p0.01);抑制凋亡Bcl-2基因的相对表达量分别下降27.0%、35.3%和52.3%,与对照组差异均为极显著(p0.01);而促进凋亡的Bax基因相对表达量分别增加1.1、2.3和3.2倍,与对照组差异均为极显著(p0.01).碘代乙酸体外诱导斑马鱼淋巴细胞凋亡的可能机制是,线粒体膜电位的崩溃导致细胞色素C持续从线粒体中释放,进而引起细胞凋亡下游通路的变化;Bcl-2基因和Bax基因明显参与了对凋亡的调控.此外,Caspase-9酶的活化导致Caspase-3酶活化,最终引起细胞凋亡.     

Saving power to conserve your reputation? The effectiveness of private versus public information

Environmental damage is often an unseen byproduct of other activities. Disclosing environmental impact privately to consumers can reduce the costs and/or increase the moral benefits of conservation behaviors, while publicly disclosing such information can provide an additional motivation for conservation - cultivating a green reputation. In a unique field experiment in the residence halls at the University of California – Los Angeles, we test the efficacy of detailed private and public information on electricity conservation. Private information was given through real-time appliance level feedback and social norms over usage, and public information was given through a publicly visible conservation rating. Our analysis is based on 7,120 daily observations about energy use from heating and cooling, lights and plug load for 66 rooms collected over an academic year. Our results suggest that while private information alone was ineffective, public information combined with private information motivated a 20 percent reduction in electricity consumption achieved through lower use of heating and cooling. Public information was particularly effective for above median energy users.     

The affective foundations of high‐reliability organizing

The factors that compel individuals to exert the extraordinary effort needed to create high reliability—consistent error‐free performance under trying conditions—remain unspecified. Here, we propose that when individuals experience emotional ambivalence and prosocial motivation, it induces the broad thinking and other‐orientation that undergird mindful organizing and high reliability. Copyright © 2014 John Wiley & Sons, Ltd.     

How do leadership motives affect informal and formal leadership emergence?

To what extent and in what ways do leadership motives of potential leaders predict their informal and formal leadership assignments? To address these questions, we conducted two studies in a military setting. In the first study (n = 215), we examined a mediated‐moderation model in which we hypothesized that the motivation to lead (MTL) of candidates to an elite unit would predict their teamwork behaviors and their tendency to emerge as leaders of their peers. We further hypothesized that cognitive ability would interact with MTL to predict teamwork behaviors and that teamwork behaviors would mediate the relationship between this interaction and leadership emergence. In Study 2, we followed up 60 candidates who were selected to the unit and examined whether MTL would predict the extent to which they achieved formal leadership roles. The findings of Study 1 supported the hypotheses included in the moderated mediation model. In Study 2, as expected, MTL predicted formal leadership emergence. We discuss several theoretical implications of these findings. Copyright © 2012 John Wiley & Sons, Ltd.     

What happens when you trust your supervisor? Mediators of individual performance in trust relationships

To understand how trust in supervisor translates into individual job performance, we hypothesize that trust in supervisor facilitates positive psychological conditions of meaningfulness, safety, and availability, which in turn predict individual job performance. We assert that each of the three mediating paths in our model represents a distinct mechanism by which trust in supervisor contributes to individual job performance. We test our hypotheses with 206 supervisor–subordinate dyads and find that trust in supervisor contributes to job performance through psychological availability and psychological safety but not psychological meaningfulness. By examining three different psychological mechanisms within the same frame, we provide a test that compares and contrasts the uniqueness of the three pathways. Our findings suggest practical ways for managers to build trust with subordinates and guidance for the design of productive work conditions. Copyright © 2012 John Wiley & Sons, Ltd.     

浅议AP1000核电建造过程本质安全化

为推进我国核电产业技术水平的整体跨越,实现我国第三代核电AP1000的自主化过程中的安全,国家核电技术公司（以下简称“国家核电”）在建造过程中通过加强从业人员安全培训、企业安全文化建设和依托项目的安全管理,大力提升人的本质安全化水平;广泛采用新技术、改进施工工艺,实行模块化、专业化施工,加大安全基础设施投入力度,强化建造过程中的安全控制,努力打造核电建造过程中物的本质安全;完善安全管理制度,建设安全责任体系和监督体系,持续提高管理上的本质安全。     

Retrofitting residential building envelopes for energy efficiency: motivations of individual homeowners in Israel

The willingness of private individuals in Israel to invest in energy-saving retrofit of the envelope of residential buildings was studied by means of a survey. Responses show that awareness of the need to conserve energy is high, but that willingness to participate in a retrofit project is modest and is limited to relatively small outlays. The decision on whether to retrofit at all, and then how much to invest in the project, is characterized as a two-stage process in which different factors may affect the outcome of each of the two stages. The major barrier to building retrofit is the perception (justified, in most cases) that the direct economic benefit to the homeowner from the resulting energy saving is small, and that given Israel's relatively mild climate, the payback period is very long. The stamp of approval provided by a government subsidy of 25% would have a large non-proportional effect on willingness to undertake building retrofit. Funding for the subsidy could be obtained from a Pigovian levy on electricity, applied for a limited period, and its environmental benefits outweigh the cost of the subsidy itself.     

科技园区高质量发展评价、驱动机理及路径研究

科技园区高质量发展是地区经济高质量发展的基础,厘清科技园区高质量发展影响因素及驱动机理有利于其优化发展路径与政策体系。首先,在文献分析的基础上构建专利授权数、R&D经费支出、人均工业增加值、固体废弃物综合利用率等15个高质量发展测度指标,应用主成分分析法分析得出科技园区高质量发展的内在因素包括创新驱动发展水平、数字设施建设水平、资源配置水平和绿色发展水平,并应用因子分析法对科技园区高质量发展进行综合评价。其次,通过归纳推理得出工业互联网价值共创、产业链整合、资源协同等是科技园区高质量发展的内在驱动机理。最后,提出加强数字基础设施建设、构建工业互联网平台生态、完善园区治理结构等实现科技园区高质量发展的路径建议。     

Impact of a Community‐Based Payment for Environmental Services Intervention on Forest Use in Menabe,Madagascar

Abstract: Despite the growing interest in conservation approaches that include payments for environmental services (PES), few evaluations of the influence of such interventions on behaviors of individuals have been conducted. We used self‐reported changes in six legal and illegal forest‐use behaviors to investigate the way in which a PES for biodiversity conservation intervention in Menabe, Madagascar, influenced behavior. Individuals (n =864) from eight intervention communities and five control communities answered questions on their forest‐use behaviors before and after the intervention began, as well as on their reasons for changing and their attitudes to various institutions. The payments had little impact on individuals’ reported decisions to change behaviors, but it had a strong impact on individuals’ attitudes. Payments appeared to legitimize monitoring of behaviors by the implementing nongovernmental organization (NGO), but did not act as a behavioral driver in their own right. Although there were no clear differences between changes in behaviors in the intervention and control communities, the intervention did influence motivations for change. Fear of local forest associations and the implementing NGO were strong motivators for changing behavior in communities with the PES intervention, whereas fear of the national government was the main reason given for change in control communities. Behavioral changes were most stable where fear of local organizations motivated the change. Our results highlight the interactions between different incentives people face when making behavioral decisions and the importance of considering the full range of incentives when designing community‐based PES interventions.