现代生物力学在煤矿安全科技中的应用研究

笔者根据国内外现代生物力学的发展情况 ,结合我国煤矿安全的现状 ,探讨现代生物力学在煤矿安全方面的应用 ,并提出了现代生物力学在安全科技两个方面的应用 :①研究人体结构在冲击事故的破坏极限 ,对安全帽的防护性能做简略的生物力学分析 ;②骨力———电性质的研究对骨折愈合与康复的意义。笔者提出随着现代科学技术的迅猛发展 ,煤矿安全方面的研究能否从现代生物力学在人体安全保护、骨折治疗与康复、职业病防治机理等方面的应用去研究的新思想和新方法 ,使煤矿安全的研究达到一个新的水平。     

Food and hunger in Sub-Saharan Africa

Sub-Saharan Africa is by far and away the most disadvantaged of the world's three main developing regions. Worse, its situation has mostly been deteriorating for much of the past several decades. Its agriculture is severely under-productive, and per capita food supplies have been steadily dwindling. Its environments and natural-resource base, characterised by water deficits, soil erosion, fuelwood shortages, rudimentary agro-practices, and grossly inadequate infrastructure, are generally unfavourable for sustainable agriculture. The population has expanded until it far exceeds carrying capacity, yet its growth rate is the highest in the world. The region also suffers from more disease than any other region. There is widespread and deepening poverty. As a result of these and other problems, and despite major food imports, two-thirds of the people are malnourished, one-quarter of whom endure outright hunger, even semi-starvation. Both these proportions appear set to keep on increasing both relatively and absolutely. Were these problems to persist with their decades-long trends, there could eventually arrive a stage when much larger numbers of people would succumb to terminal malnutrition, precipitating a human tragedy of unprecedented proportions. Fortunately, success stories demonstrate that solutions are available, on the part of both governments concerned and international agencies. Because of ignorance, or rather ignore-ance of the potential mortality disaster ahead, however, not nearly enough has been done to address the challenge with the energy and urgency to match its scale.     

作业场所职业危害信息系统共享数据元标准化初探

通过对国内外数据元标准化研究现状的分析,以探索实现作业场所职业危害信息系统相关数据元标准化为前提,实现作业场所职业危害信息系统数据共享及发布为目的,指出传统基于数据集共享模式存在的统一性共享性差的问题,研究建立基于数据元和数据集相结合的标准化技术路线,并结合作业场所职业危害用人单位相关数据元采集、提取及标准化过程进行应用和示范,实现不同作业场所职业危害信息系统间相关数据共享。     

石英砂加工企业职业病危害防护措施与管理对策研究

通过对安徽省石英砂加工企业生产工艺流程和现场进行调查分析,得出矽尘和噪声是两种最主要的职业病危害因素,发现石英砂生产企业矽尘和噪声危害十分严重,生产作业现场未配备任何防护装备和个人防护用品,作业人员接触职业病危害的比率非常高。分析了石英砂加工企业在职业病危害防护与管理方面的欠缺与不足,提出了针对矽尘和噪声危害因素的具体工程防护措施与管理对策,从源头控制和消除职业病危害,保护劳动者的生命安全与健康。     

通用电气风险评估模式在我国中小企业干预中的应用及效果评估

为提高对职业危害的识别和控制能力,采用跨国企业风险评估模式帮助我国中小企业改善职业健康与安全管理。选用通用电气环境健康安全管理体系中的11个相关元素作为评估工具,对企业开展干预,并评估效果。结果表明,干预效果较好,工人接触有害物质的水平明显降低,个体防护用品使用率和正确使用率有较大提高,职业危害风险评估符合率有明显提高。应用风险评估模式干预的示范企业,职业卫生现状得到有效改善,为企业管理提供了借鉴。     

IKK inhibition prevents PM2.5-exacerbated cardiac injury in mice with type 2 diabetes

Epidemiological studies have found that individuals with diabetes mellitus(DM) display an increased susceptibility for adverse cardiovascular outcomes when exposed to air pollution.This study was conducted to explore the potential mechanism linking ambient fine particles(PM2.5) and heart injury in a Type 2 DM(T2DM) animal model. The KKay mouse, an animal model of T2DM, was exposed to concentrated ambient PM2.5 or filtered air for 8 weeks via a versatile aerosol exposure and concentrator system. Simultaneously, an inhibitor of IκB kinase-2(IKK-a)(IMD-0354), which is a blocker of nuclear factor κB(NF-κB)nuclear translocation, was administrated by intracerebroventricular injection(ICV) to regulate the NF-êB pathway. The results showed that ambient PM2.5 induced the increase of, NF-êB, cyclooxygenase-2(COX-2) and mitogen activated protein kinase(MAPK) expression in cardiac tissue, and that IMD-0354 could alleviate the inflammatory injury. The results suggested that the NF-êB pathway plays an important role in mediating the PM2.5-induced cardiovascular injury in the T2DM model. Inhibiting NFκB may be a therapeutic option in air-pollution-exacerbated cardiovascular injury in diabetes mellitus.     

Prenatal exclusion of Leigh syndrome due to T8993C mutation in the mitochondrial DNA

Leigh syndrome (LS) is a mitochondrial encephalopathy that is caused by a mutation either in the mitochondrial DNA (mtDNA) or in the nuclear encoded genes of the mitochondrial proteins. Prenatal diagnosis of defects in the mtDNA is usually problematic because of mtDNA heteroplasmy and tissue specificity. However, the mutations T8993 G/C in the ATP synthase subunit 6 gene of the mtDNA show a more even tissue distribution and do not appear to change significantly over time. There are only few reports of prenatal diagnosis of the T8993G mutation in Leigh disease. Here we describe the first prenatal genetic testing of T8993C in a fetus of a mother whose previous child had died of Leigh syndrome due to the T8993C mutation. Mutant load in the chorionic villus sample (CVS) as well as in amniocytes was undetectable, thus predicting a very high likelihood of an unaffected outcome, indicative of a healthy baby. The diagnosis was confirmed after birth. Gathering data on the prenatal diagnosis of mtDNA mutations is of great importance so that prenatal diagnosis of both T8993G and T8993C mutations can be offered routinely. Copyright © 2002 John Wiley & Sons, Ltd.