Tools for an enhanced solvent properties screening in the early stages of pharmaceutical process development

The objective of this research was the implementation of tools for the evaluation of solvents trough property screening in the early stages of process development. An important feature of the tools is that the implementation of indexes, scores, or weights is avoided. Information already available from the literature was stored in a database in order to turn raw data into decision making information. As a result, a solvent radar chart, a solvent representation table, and a solvent telescopying tool were developed in an ASP.NET application. The synthesis of Propranolol was used as study case in order to explore the selection of solvents in the early stages of process development. The replacement of diethyl ether was possible in the extraction step, while solvent choices were detected for potential telescoping for extraction and crystallisation steps. Solubility was found as a critical parameter in telescoping analysis. The methodology proposed enhanced the view towards a more holistic perspective and a more robust solvent screening process. As a consequence, the next steps into solvent evaluation and process development can be reduced.     

机电产品可靠性研究与探讨

机电产品越来越广泛地应用于社会各个领域,随着自动化、小型化程度的提高,很多机电产品结构越来越复杂,并且其使用条件也越来越严酷,由此产生的产品可靠性问题必然越来越多,可靠性技术也越来越受到重视。本文针对机电产品,从可靠性管理、可靠性设计和分析、可靠性试验和评定三个方面,对可靠性研究工作进行初步探讨。     

Biodegradable Films Based on Blends of Gelatin and Poly (Vinyl Alcohol): Effect of PVA Type or Concentration on Some Physical Properties of Films

The aim of this work was to develop biodegradable films based on blends of gelatin and poly (vinyl alcohol) (PVA), without a plasticizer. Firstly, the effect of five types of PVA with different degree of hydrolysis (DH) on the physical properties of films elaborated with blends containing 23.1% PVA was studied. One PVA type was then chosen for the study of the effect of the PVA concentration on the mechanical properties, color, opacity, gloss, and water solubility of the films. The five types of PVA studied allowed for films with different characteristics, but with no direct relationship with the DH of the PVA. Therefore, the PVA Celvol^®418 with a DH = 91.8% was chosen for the second part, because they produced films with greater tensile strength. The PVA concentration affected all studied properties of films. These results could be explained by the results of the DSC and FTIR analyses, which showed that some interactions between the gelatin and the PVA occurred depending on the PVA concentration, affecting the crystallinity of the films.     

污泥化学调理和机械脱水方面的研究进展

综述了近几年来国内外有关化学药剂单独或联合调理对污泥脱水性能的影响。污泥颗粒尺寸、污泥化学组成对污泥脱水性能的影响。以及污泥化学调理的静电作用过程、污泥离心脱水过程、污泥过滤和挤压固化脱水过程等方面的研究进展。汇总了实验研究中常用的参数指标．并展望今后在污泥调理和机械脱水方面的发展动态。     

常温下低浓度EGSB反应器的启动运行

系统考察接种市政污泥EGSB反应器的初次启动,以确定EGSB在常温低浓度情况下接种市政污泥时快速形成高活性、稳定颗粒污泥的可行性。接种市政污泥的EGSB反应器在常温条件下能够在42d内快速启动,所产生的颗粒污泥沉淀性良好、产甲烷活性高且菌群丰富,出水p（COD）稳定在60mg／L以下,其他指标也均达到相应国家标准。在常温下启动EGSB宜采用低进水浓度、较高的有机负荷、较大的上流速度的方式。     

某城市地下车库联络通道的消防安全研究

城市地下车库联络通道作为一种新型的地下交通联络通道,可净化地面交通,提高土地利用率,解决城市交通拥堵问题。然而这种通道兼有地下车库和城市交通隧道的特点,结构复杂,一旦发生火灾,损失较大。其防火设计的难点在于如何定性并选择合适的规范条文,因此有必要系统研究其消防安全问题并提出有效解决方案。以某城市地下车库联络通道为例,研究该通道的火灾危险性,提出防火分隔、探测报警、排烟以及人员安全疏散等消防设计方案和管理对策,并通过数值模拟方法验证了该方案的有效性和可行性。     

城市土壤吸附重金属动力学特征及其与土壤理化性质的关系

以长春市土壤为对象,既研究了长春市土壤理化性质特征,又采用间歇法研究了城市土壤吸附重金属Pb、Cd和Cu动力学特征及其两者之间的关系。结果表明：长春市土壤pH接近于中性或者偏碱性;土壤碳酸钙、有机质含量升高;土壤砂粒化;土壤CEC和Eh具有逐渐降低的趋势。土壤吸附重金属动力学过程包括快速阶段和慢速阶段,不同重金属在不同吸附阶段吸附速率明显不同。双常数速率方程和Elovich方程基本上可以描述土壤对Pb、CA和Cu吸附的动力学过程。pH、碳酸钙和砂粒含量是影响Pb吸附速率的主要因子;碳酸钙含量是影响CA吸附速率的主要因子。     

基于油水分离的餐饮废水破乳化技术研究

餐饮废水中乳化油的分离处理一直是一个技术难题,文章分别采用物理机械方法和物理化学方法对餐饮废水进行了破乳化研究。通过对比试验结果和分析破乳机理,总结出各方法不同的破乳特点。结果表明,温度越高分离效果越好,但在实际应用中,保持在50～60℃即可。低功率的超声波可以促进破乳效果,但超过30W,又会使溶液发生乳化反应。小分子醇类的加量越多,破乳化作用越强;醇类单链越长,分离效果越好。加入无机盐,在一定程度上可以加快破乳化速度,但效果并不明显。     

How safe are standard certified motorcycle safety helmets? Malaysian postal delivery riders scenario

Objective: The objective of this study was to determine the proportion of motorcycle safety helmets (MSHs) used by postal delivery riders (PDRs) that comply with the Standards and Industrial Research Institute of Malaysia’s (SIRIM) MSH standard guidelines and identify factors that contribute toward compliance of used MSHs with the standards.

Methods: The presence of SIRIM certification label, the status of MSH, type of chinstrap, MSH crash history, and duration of MSH use were observed. The dependent variable was the results of the SIRIM testing procedures (SIRIM tests). MSHs that passed the SIRIM tests were considered “standard certified” MSHs.

Results: The odds of the complimentary MSHs passing all of the SIRIM tests were 3.7 times the odds of the self-purchased MSHs passing the tests. The odds of MSHs with the SIRIM certification label passing all of the SIRIM tests were 24.2 times the odds of MSHs without the SIRIM certification label, and the odds of MSHs used <3?years passing the SIRIM tests were 3.75 times the odds of the MSHs used ≥3.8?years.

Conclusion: PDRs provided with complimentary MSHs with the SIRIM certification label by the employer for their daily delivery routines and duration of MSH used for less than 3 years were found to be safe MSHs for male occupational riders in Malaysia.     

生产工艺参数对高碳钢线材力学性能的影响

用正交试验的方法研究了不同工艺参数对高碳钢力学性能的影响.分析了82MnA钢线材的生产工艺参数.