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51.
There is a great deal of concern regarding the adverse effects of polychlorinated dibenzodioxins (PCDD) and polychlorinated dibenzofurans (PCDF) present in Agent Orange and other herbicides on Vietnam's population and ecosystems. The purpose of this study was to determine the effect of dioxin exposure on adrenal steroids in saliva, and dioxin levels in breast milk, of primiparas in an Agent Orange/dioxin hot-spot and a non-exposed area in Vietnam on the basis of epidemiological research. The subjects were 35 lactating women who had recently given birth to their first or second child. A further sub-study involved eight primiparas from each area. All subjects were aged between 20 and 30 years with infants aged between 4 and 16 weeks. The mean concentration of PCDD, PCDF, and PCDD?+?PCDF toxic equivalents (TEQ) in breast milk in the hot-spot area was significantly higher than in the non-exposed area. Cortisol and cortisone levels in the saliva of primiparas in the hot-spot area were also significantly higher than those in the non-exposed area. There was a significant negative correlation between cortisol and the cortisol/cortisone ratio and PCDD?+?PCDF and PCDF TEQ levels in the hot-spot area. Furthermore, the correlation between cortisol and cortisone and the PCDD + PCDF, PCDD, and PCDF TEQ in the combination of hot spot + non-exposed area was significant according to the curve (bell style). Our results suggest that Agent Orange/dioxin exposure still exerts a major influence on the salivary hormones of the Vietnamese population. 相似文献
52.
Dang Duc Nhu Teruhiko Kido Nguyen Ngoc Hung Le Thi Hong Thom Rie Naganuma Le Ke Son 《毒物与环境化学》2013,95(4):824-838
Human exposure to polychlorinated dibenzodioxins (PCDD) and dibenzofurans (PCDF), especially 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD), was investigated in Vietnam since initial severe adverse health effects were reported in the late 1970s. The purpose of this study was to determine the effects of dioxin exposure on steroid hormones of primiparae in an Agent Orange/dioxin hot-spot and a non-exposed area in Vietnam. Sixteen primiparae (8 at each site), all of whom were aged between 20 and 30 years with infants aged between 4 and 16 weeks, agreed to participate in this study. The mean dioxin levels in breast milk of primiparae from the hot-spot area, in terms of PCDD, PCDF, and PCDD?+?PCDF toxic equivalents (TEQ), were significantly higher than those for the non-exposed area. PCDD TEQ, PCDF TEQ, and PCDD?+?PCDF TEQ levels showed a significant correlation with dehydroepiandrosterone (DHEA), androstenedione (A-dione), and estradiol (E2) in the saliva of primiparae in a combination of hot-spot and non-exposed areas in Vietnam. The dose–response curve between salivary E2 or A-dione levels and dioxin levels was U-shaped in humans. This study provides an overview of studies regarding dioxin hot-spots and effects on human health and steroid hormone levels in particular, with a focus on the toxicity attributed to dioxins and furans. Furthermore, causal evidence regarding the effects of dioxins on endocrine disruption in humans is provided. 相似文献
53.
T.?N.?K.?D.?Binhvnn.vn" title="pvpialy@hcm vnn.vn" itemprop="email" data-track="click" data-track-action="Email author" data-track-label="">Email author Nico?Vromant Nguyen?Thanh?Hung Luc?Hens E.?K.?Boon 《Environment, Development and Sustainability》2005,7(4):519-536
Since 2000, the shrimp industry expands at a fast rate in the coastal areas of the Mekong Delta, Vietnam. Shrimp farming is
known for its negative impact on the coastal environment. However, other human interventions like agriculture and urbanization
also deteriorate the coastal environment. The land cover changes between 1968 and 2003 were determined and analyzed for the
Cai Nuoc district, Ca Mau Province, Vietnam, using photos from 1968, 1992 (aerial photographs), 1997/98 (Spot) and 2003 (Landsat).
It was clear that the district underwent serious land cover changes: deforestation between 1968 and 1992, with a simultaneous
increase in rice land; a rapid decline in rice acreage from 1997 onwards, and, simultaneously, a blitz-increase in shrimp
farming area. The forest area declined by 75% between 1968 and 2003. About 40% of this loss could be attributed to shrimp
farming, while the remaining 60% was attributed to needs for agricultural land. Still, at present, shrimp farming is the major
source of mangrove loss in the district. In 1999 shrimp farms covered 6.374 ha, in 2000 they covered 61.049 ha of the Cai
Nuoc area. The swap from rice cultivation to shrimp farming was most-probably driven by households’ hopes for a higher income.
It must be feared that the shrimp industry will have a negative impact on the environment (e.g. salinization) and on the livelihood
of the district’s households. In 1968 saline water covered 219.9 km2, in 1992, 1997/98 and 2003 the saline surface water area covered 92.4, 135.2 and 835.0 km2, respectively.
Readers should send their comments on this paper to: BhaskarNath@aol.com within 3 months of publication of this issue. 相似文献