Maternal serum thyroid antibodies in early pregnancy and fetal Down's syndrome

Thyroid antibodies were measured in mid-trimester antenatal serum samples from 77 pregnancies affected by fetal Down's syndrome and 385 unaffected control pregnancies. Using a haemagglutination technique, thyroglobulin antibodies were detected in 5·2 per cent of cases (4) and 2·9 per cent of controls (11), and thyroid microsomal antibodies were detected in 22 per cent (17) and 15 per cent (59), respectively. Using an enzyme-linked immunosorbent assay (ELISA) for thyroglobulin antibodies and a cut-off level of 50 KIU/1, positive results were found in 25 per cent of cases (19) and 22 per cent of controls (84). Using an ELISA for thyroid microsomal antibodies and the same cut-off level, the proportions were 52 per cent (40) and 39 per cent (149), respectively. While not statistically significant, the differences were consistent with the previously reported increased levels of thyroid antibody found in nonpregnant women who had had pregnancies associated with Down's syndrome.     

Activity of biotin-dependent and gaba metabolizing enzymes in chorionic villus samples: Potential for 1st trimester prenatal diagnosis

We have documented the presence of five mitochondrial enzymes in samples of chorionic villus tissue and measured the levels of activity. Three of the enzymes catalyse biotindependent reactions. These are propionyl-CoA carboxylase, 3-methylcrotonyl-CoA carboxylase and pyruvate carboxylase. the other enzymes. 4-aminobutyric acid aminotransferase and succinic semialdehyde dehydrogenase, are involved inthe degradation of the central inhibitory neurotransmitter GABA. Distinct diseases in whichthere is deficiency of each of these enzymes have been documented in man. Significant levels of activity were observed for all five enzymes in chorionic villus tissue. This methodology should permit early prenatal diagnosis of deficiencies of these enzymes by chorionic villus biopsy in the first trimester.     

The cerebro-hepato-renal (Zellweger) syndrome: Prenatal detection based on impaired biosynthesis of plasmalogens

Prenatal diagnosis of the cerebro-hepato-renal (Zellweger) syndrome has been performed in 10 pregnancies at risk by measuring both the activity of acyl CoA: dihydroxyacetonephosphate acyltransferase (DHAP-AT) and the de novo plasmalogen biosynthesis, either in cultured amniotic fluid cells or in fibroblasts cultured from a chorionic villus biopsy. In 7 of the pregnancies both tests indicated no abnormality. All 7 continued to term and normal infants were delivered. However, in amniotic fluid cells from 2 fetuses affected by Zellweger syndrome unequivocal differences from control values were found. The activity of DHAP-AT was clearly deficient and the de novo plasmalogen biosynthesis was impaired. In one pregnancy at risk prenatal diagnosis was performed during the first trimester by measuring both the DHAP-AT activity and the de novo plasmalogen biosynthesis in fibroblasts cultured from a chorionic villi biopsy. From the deficient DHAP-AT activity and the impaired de novo plasmalogen biosynthesis it was concluded that the fetus was affected. This was confirmed biochemically after induced abortion. It can be concluded that measurement of the DHAP-AT activity and the de novo plasmalogen biosynthesis provides convenient methods for the early prenatal detection of Zellweger syndrome.     

里彦煤矿矿井水净化处理

根据里彦煤矿矿井水水质和处理规模确定处理工艺流程、主要工艺参数、主要建（构）筑物，并进行经济分析。里彦煤矿矿井水净化处理后作为生产和生活用水，具有较好的经济、环境和社会效益。     

我国水资源的可持续利用和保护

随着科技的进步和经济的发展，我国水环境污染状况越来越严重，可以利用的淡水资源日益短缺，已成为制约我国经济发展的一项重要因素，我国政府为了解决我国的水资源问题，提出了“开源与节流”的重大举措，这对缓解我国目前的水资源短缺状况将起到非常重要的作用。本文就这些方面进行了论述，希望能引起大家对水的忧患意识。     

SBR法运行控制工艺研究进展

SBR法是一种具有独特的优点的废水生物处理工艺，但至今还没有一套公认的运行控制工艺，本文从SBR法的启动，充水时间及反应时间的确定，模糊控制，目标控制操作等几方面对SBR工艺的运行控制做了评述，并对其今后的研究方向做了展望。     

造纸废水综合治理技术的应用研究

采用“酸化 物化 生化”组合工艺并辅以芦苇湿地处理系统对造纸废水进行综合治理。通过优化工艺条件 ,逐级削减污染负荷 ,使废水排放达到国家标准     

积极推行ISO14000，促进中国商品的出口

介绍了国际贸易中的环境壁垒问题，提出了解决环境壁垒，促进中国商品出口的具体办法。     

灰色局势决策模型在生态环境综合整治方案优化中的应用

应用灰色系统理论，将安徽省环境问题归纳为１０类事件，针对这些事件提出 对策，建立灰色局势决策模型，得到了符合安徽省社会、经济、技术及环境条件的优化决策方案。研究表明，灰色局势决策模型原理简单，计算简便，结果可靠，是玫中很实用价值的多方案优化模型。     

锡林郭勒盟建立节水型社会对策措施探讨

我国水资源总量并不少,但人均水资源的占有量只有世界人均占有量的四分之一,属于世界上几个最为缺水的国家之一.锡盟地处内蒙古中部地区,水资源在地区和季节分布不均,同时潜在的水污染也是水资源短缺的重要原因,本文试探讨节约和保护水资源的对策和措施.