United states survey on chromosome mosaicism and pseudomosaicism in prenatal diagnosis

The survey of the incidence of chromosome mosaicism and pseudomosaicism detected in prenatal diagnosis included data from approximately 60 000 genetic amniocenteses in the United States. There were 59 participating cytogenetic laboratories nationwide. The overall incidence of chromosome mosaicism was 0.25 per cent (range of 0–0.89 per cent). The average frequency of pseudomosaicism involving multiple cells or clones was 0.7 per cent (range of 0–11.21 per cent). The frequency of single cell or clone pseudomosaicism was 2.47 per cent (range of 0–11.49 per cent). In cases of pseudomosaicism with trisomy, the most frequently involved chromosome was number 2; occurrence rates of trisomies 7,X,9,17 and 20 were also relatively high. In cases of pseudomosaicism with structural abnormalities, this survey showed an association between relative chromosome size and the frequency of involvement in structural rearrangement. Data on a total of 185 cases of chromosome mosaicism collected in this survey as well as from other documented sources showed 89 cases involved an autosome, 13 cases a sex chromosome, and 23 a marker chromosome. The frequency of noticeable phenotypic abnormalities was highest (37.8 per cent) in the autosomal mosaics and lowest (10.5 per cent) in the sex chromosome mosaics. The average rate for cytogenetic confirmation was 70 per cent.     

Uranium isotopes in groundwater from the continental intercalaire aquifer in Algerian Tunisian Sahara (Northern Africa)

The disequilibrium between ²³⁴U and ²³⁸U is commonly used as a tracer of groundwater flow. This paper aims to identify uranium contents and uranium isotopic disequilibria variation in groundwater sampled from deep Continental Intercalaire aquifer (southern Algeria and Tunisia). Large variations in both U contents (0.006–3.39 ppb) and ²³⁴U/²³⁸U activity ratios (0.4–15.38) are observed. We conduct a first assessment in order to verify whether the results of our investigation support and complete previous hydrogeological and isotopic studies. The dissolved U content and ²³⁴U/²³⁸U activity ratio data were plotted on a two-dimensional diagram that was successfully utilized on sharing the CI aquifer into different compartments submitted to different oxidising/reducing conditions and leads also to distinguished two preferential flow paths in the Nefzaoua/Chott Fejej discharge area. Uranium isotopes disequilibrium indicate that ranium chemistry is mainly controlled by water–rock interaction enhanced by long residence time recognised for this aquifer.     

微囊藻毒素对真菌和哺乳动物细胞毒害效应的研究

主要探讨微囊藻毒素对真菌和哺乳动物细胞的毒害效果,以及其作为水体生理毒害评价模式细胞的可能。通过毒性试验和单细胞凝胶电泳实验,利用栗酒裂殖酵母细胞（S.pombe）,人肝癌细胞（HepG2）和人脑星形胶质母细胞癌细胞（U87）3种生物模型评估MC对细胞DNA的损伤以及对细胞内氧化自由基水平的影响。并利用栗酒裂殖酵母的基因缺失体,判断MC所诱导的酵母细胞氧化应激路径。研究表明MC通过氧化路径诱导DNA损伤;缺失wis1△和pap1△基因的S.pombe细胞无法诱导ROS生产,wis1△和pap1△缺失型S.pombe细胞在40 mg·L-1-1MC暴露24 h下细胞增殖率仅下降7.3%、7.7%;氧化损伤是MC损伤S.pombe的主要方式;HepG2细胞和U87细胞较S.pombe细胞适于研究、评估MC的毒性。     

论美国能源监管立法与能源管理体制

美国联邦政府从20世纪30年代开始制定能源监管立法。依据集中程度和立法主题,美国能源监管立法可分为电力管控、核能监管、能源安全、放松管制等4个发展时期。根据现行美国能源立法．美国能源管理体制分为联邦和州两个层次。在联邦层次,对能源进行监管的部门有美国能源部、联邦能源监管委员会、核能监管署、环境保护署、国会内政部等。其中,能源部主要负责能源发展和安全的大政方针的制定,联邦能源监管委员会的使命在于通过管制和市场的手段执行能源立法及能源政策。在州层次,一般由州能源委员会、州公用事业委员会以及州环保局负责州的能源监管。     

工业用水与经济发展的关系——用水库兹涅茨曲线

经验数据显示,发达国家工业用水随经济发展的变化存在着一个由上升转而下降的转折点。因此,工业用水随收入增长的演变模式可以用库兹涅茨曲线形式来表示。工业用水下降点对应的人均GDP的阈值是3700-17 000US$(PPP,以1985年为基数)。与之相应的第二产业在GDP总量中所占份额是30％～50％。工业用水下降的直接原因是用水效率的提高,其来源有两方面:部门用水效率的提高和经济结构调整。这提供了一个积极的信号,即发展中国家的工业用水将不会一直持续增长,从而为更好地预测发展中国家的工业用水量提供非常重要的思路,也为正确把握用水变化规律,制定符合规律的水资源对策提供科学基础。     

改性废弃皮革对U(VI)的动态吸附

以改性废弃皮革为吸附剂对U(VI)进行动态吸附实验,采用直径3 cm、高50 cm的玻璃吸附柱,在填料高度为3、4和5 cm,U(VI)溶液进水流速为0.85、1.7和2.55 mL·min-1,初始U(VI)浓度为6、12和18 mg·L-1的条件下,考察了各因素对U(VI)吸附穿透曲线的影响。动态实验表明：柱高的降低、流速的增大和U(VI)浓度的增加均会使穿透时间提前;动态吸附穿透曲线能很好地符合Thomas模型的条件（R2>0.95）,同时吸附量的预测值与实际测试值较为接近。使用穿透时间（ta）与填料高度（h）的关系式ta=220h-433(R2=0.998),在仅改变流速和初始U(VI)浓度时,穿透时间预测值与实际测试值相差较小,表明BDST模型能确定固定床的动态吸附周期。     

铀尾矿库渗漏地下含水层中六价铀的几种吸附反应运移模型对比

在铀尾矿地区,溶解态U(Ⅵ)渗漏到含水层中会对周围环境造成严重的威胁.使用反应运移软件PHT3D对U(Ⅵ)在含水层中的迁移和吸附过程进行模拟.结果表明,相比于不考虑吸附情形,考虑吸附的U(Ⅵ)反应迁移阻滞现象明显.线性和Langmuir吸附等温线模型在水动力条件复杂、地球化学条件多变时的模拟效果与表面络合模型相比较差,甚至有时得到与实际相反的结果,这说明了传统Kd吸附经验模型的局限性.由表面络合模型计算得出的分配系数Kd值是时空变化的,其更能反映实际中多变水化学条件下的吸附过程,适合描述复杂的不同水文地球化学条件.     

生态安全弹性与生态安全"倒U"曲线

文章从生态安全的研究现状入手,根据生态系统和人类社会系统之间的主要关系,论述了生态安全弹性和安全"倒U"曲线理论.生态安全弹性能够反映安全系数、安全阈值、干扰程度三者的关系,由它来判断人类向生态系统索取自然资源的活动更具有预测性、可操作性,并能保证生态系统自身也处于可持续发展的良性状态.     

美国职业卫生法规、监管及统计体系

美国是工业发达国家,是世界上最早建立“职业安全和卫生法”的国家之一。基于该法,美国确立以职业安全卫生监察局(OSHA)为执法机构、职业安全卫生复审委员会(OSHRC)为监督机构的职业卫生监管体系;同时,以劳工统计局(BLS)为统计主管机构,建立以“1904规范”为基础的企业雇主对其作业场所职业卫生记录和报告制度,并辅以两种形式的政府主动调查,形成了自下至上和自上至下相结合的调查统计体系。目前,我国职业卫生的调查统计体系尚未形成。因此,需要从工业发达国家的职业卫生法规、监管入手,以系统的方法和思路,分析其调查统计体系,学习工业发达国家的经验。研究结果认为美国的职业卫生统计体系具有上层法律及相关条例完备、组织体系职责分明、形成了政府主动调查与企业记录报告相结合的调查统计体系等明显的特点。     

Variability and predictability of sea-level extremes in the Hawaiian and U.S.-Trust Islands—a knowledge base for coastal hazards management

The objective of this study is to provide an improved climatology of sea level extremes on seasonal and long-term time scales for Hawaii and the U.S-Trust islands. Observations revealed that the Hawaiian and U.S.-Trust islands, by and large, display a strong annual cycle. For estimating the statistics of return period, the three-parameter generalized extreme value (GEV) distribution is fitted using the method of L-moments. In the context of extremes (20- to 100-year return periods), the deviations in most of the Hawaiian Islands (except at Nawiliwili and Hilo) displayed a moderate sea-level rise (i.e., close to 200 mm), but the deviations in the U.S.-Trust islands displayed a considerably higher rise (i.e., more than 300 mm) in some seasons due to typhoon-related storm surges. This rise may cause damage to roads, harbors, and unstable sandy beaches. Correlations between the El Niño-Southern Oscillation (ENSO) climate cycle and the variability of seasonal sea level have been investigated. Results show that correlation for the station located west of the International Date Line (DL) is strong, but it is moderate or even weaker for stations east of the DL. The skill of SST-based Canonical Correlation Analyses (CCA) forecasts was found to be weak to moderate (0.4–0.6 for Honolulu, Kahului, Hilo, and Wake, and 0.3 or below for Kahului, Mokuoloe, and Johnston). Finally, these findings are synthesized for evaluating the potential implications of sea level variability in these islands.