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71.
Tetrabromobisphenol A (TBBPA) and its derivatives are now being highly concerned due to their emerging environmental occurrence and deleterious effects on non-target organisms. Considering the potential neurotoxicity of TBBPA derivatives which has been demonstrated in vitro, what could happen in vivo is worthy of being studied. Tetrabromobisphenol A bis(2-hydroxyethyl ether) (TBBPA-BHEE), a representative TBBPA derivative, was selected for a 21-day exposure experiment on neonatal Sprague Dawley (SD) rats through intranasal administration. The neurobehavioral, histopathological changes, and differentially expressed genes based on RNA microarray were investigated to evaluate the neurological effects of this chemical. The results indicated that TBBPA-BHEE exposure significantly compromised the motor co-ordination performance and the locomotor activities (p < 0.05). The neurobehavioral phenotype could be attributed to the obvious histopathological changes in both cerebrum and cerebellum, such as neural cell swelling, microglial activation and proliferation. A total of 911 genes were up-regulated, whereas 433 genes were down-regulated. Gene set enrichment analysis showed multiple signaling pathways, including ubiquitin-mediated proteolysis and wingless-int (Wnt) signaling pathway etc. were involved due to TBBPA-BHEE exposure. The gene ontology enrichment analysis showed the basic cellular function and the neurological processes like synaptic transmission were influenced. The toxicological effects of TBBPA-BHEE observed in this study suggested the potential neuronal threaten from unintended exposure, which would be of great value in the biosafety evaluation of TBBPA derivatives. 相似文献
72.
把促进私有经济发展和改善环境质量作为我们建设项目环境管理的责任和义务。针对目前民营小型企业建设项目环境管理现状,指出:在管理中应加强环境保护宣传和舆论监督、依法施政、居民参与、管理与服务并重四方面意见。 相似文献
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74.
《中华人民共和国防震减灾法》等一系列法律、规章的出台实施,规范了防震减灾的管理体制、行政执法,并将地震部门作为行政主体推向了依法行政的前沿。笔者结合自己在行政办事中心“窗口”的工作实际,对防震减灾依法行政工作的特点和存在问题进行一些简单的探讨。 相似文献
75.
Numerous empirical and simulation-based studies have documented or estimated variable impacts to the economic growth of nation states due to the adoption of domestic climate change mitigation policies. However, few studies have been able to empirically link projected changes in economic growth to the provision of public goods and services. In this research, we couple projected changes in economic growth to US states brought about by the adoption of a domestic climate change mitigation policy with a longitudinal panel dataset detailing the production of outdoor recreation opportunities on lands managed in the public interest. Joining empirical data and simulation-based estimates allow us to better understand how the adoption of a domestic climate change mitigation policy would affect the provision of public goods in the future. We first employ a technical efficiency model and metrics to provide decision makers with evidence of specific areas where operational efficiencies within the nation's state park systems can be improved. We then augment the empirical analysis with simulation-based changes in gross state product (GSP) to estimate changes to the states’ ability to provide outdoor recreation opportunities from 2014 to 2020; the results reveal substantial variability across states. Finally, we explore two potential solutions (increasing GSP or increasing technical efficiency) for addressing the negative impacts on the states’ park systems operating budgets brought about by the adoption of a domestic climate change mitigation policy; the analyses suggest increasing technical efficiency would be the most viable solution if/when the US adopts a greenhouse gas reduction policy. 相似文献
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77.
《中华人民共和国防震减灾法》等一系列法律、规章的出台实施,规范了防震减灾的管理体制、行政执法,并将地震部门作为行政主体推向了依法行政的前沿。笔者结合自己在行政办事中心“窗口”的工作实际,对防震减灾依法行政工作的特点和存在问题进行一些简单的探讨。 相似文献
78.
城市总体规划环境影响评价的探讨 总被引:1,自引:0,他引:1
陶平 《辽宁城乡环境科技》2006,26(6):41-44
我国城市总体规划的环境影响评价刚刚起步,其研究的技术方法体系还处于探讨阶段,这给城市总体规划环境影响评价的实施带来了理论和实践上的障碍。文中针对城市总体规划设计了评价指标体系,从规划分析、环境影响分析、减缓措施和环境管理计划4方面阐述了评价内容。并对现有的评价技术方法进行了总结。 相似文献
79.
随着城市化步伐不断加快,城市环境问题日趋复杂和多元,环境管理成为城市这一复杂系统处于最优运行状态的重要保障。当代环境管理的实质,是将人与自然的关系协调到有利于人类生存与发展的和谐状态,环境管理创新是生态文明建设的根本保障。针对城市环境管理存在着环境法规不完善、行政管理制度不健全、缺乏经济手段和公众参与程度低等问题,本文从环境立法、行政管理制度、环境经济政策与公众参与机制等方面提出了若干对策建议,为完善城市环境管理制度提供参考。 相似文献
80.
介绍了ISO14000环境管理体系的内容。通过分析我国石化企业的现状和建立ISO14000环境管理体系的意义,提出了建立ISO14000环境管理体系是提高企业管理水平的有效途径的观点。最后,探讨了现阶段石化企业建立ISO14000环境管理体系的步骤。 相似文献