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91.
The effect of repeat testing in maternal serum multiple marker screening for Down's syndrome was estimated using samples stored in an antenatal serum bank. Human chorionic gonadotropin (hCG) and unconjugated oestriol (uE3) levels were determined in 142 pairs of routinely collected samples which had already been tested for alpha-fetoprotein (AFP). For each marker, about two-thirds of the pairs of values were within 20 per cent of each other and most were within 40 per cent. A multivariate Gaussian model was used to estimate the detection and false-positive rates for different repeat testing policies. A policy of repeat testing those with a high risk of a Down's syndrome term pregnancy given age and marker levels would reduce the false-positive rate but there would also be a reduction in the detection rate. For example, using all three markers and a 1 in 250 cut-off risk, the estimated false-positive rate would fall from 5·3 to 3·8 per cent but the detection rate would decrease from 58 to 55 per cent. A policy of repeating those with either high or borderline risks would produce a modest improvement in screening efficiency. Repeating the 11 per cent with a risk exceeding 1 in 500 yields an estimated false-positive rate of 5·0 per cent and a detection rate of 60 per cent. A policy of selective repeat testing is not recommended as it would not substantially improve screening efficiency. Nonetheless, if a repeat test has been performed, the parameters given in this paper will enable an unbiased estimate of the Down's syndrome risk to be calculated for individual women. 相似文献
92.
生态型组合人工湿地污水处理工艺 总被引:1,自引:0,他引:1
建立了由生物调节池、好氧降解与微生物培养池、潜流湿地和表流湿地组成的生态型污水处理组合工艺系统,用以处理生活污水和试验室废水。系统连续运行2年的处理效果持续稳定,出水水质达到国家(GB 18918-2002)1级排放标准。该工艺的建设成本和运行成本低,用地面积小于2 m2/t,建设成本为300~500元/t,运行耗电量小于0.1元/t,管理维护等费用约为0.1元/t,运行合计费用小于0.2元/t,该生态型组合人工湿地所具有的环境效益、经济效益及社会效益,对于处理水量不大、水质变化不太大,管理水平不太高的广大中小城镇、居民小区尤其适用。 相似文献
93.
Fluoride contamination in soil was studied in the vicinity of a hot spring in Nayagarh district of Orissa. Both bulk soil from 0 to 30 cm depth and profile soils from 0 to 90 cm depth were analyzed for total fluoride (Ft) and 0.01 M CaCl2 extractable fluoride (Fca), major elements, pH, EC and Organic Carbon (OC). High concentrations of both Ft and Fca were observed in the area surrounding the hot spring and the village of Singhpur. Principal factor analysis (PFA) on the parameters of the bulk soils suggests that two major chemical processes due to three factors, control the soil geochemistry of the area. Factor-1 contributes 37.11% of the total variance and is strongly loaded with Al, Si, Fe, Ftand Fca, and explains the fluoride enrichment of the soil, whereas the second and the third factors contribute 16.6 and 12.2%, respectively and explain the controlling process of carbonate precipitation and soil alkalinity. Multiple regression analysis of the scores of the factors was performed to derive a fluoride contamination index in soil. The magnitude of the factor effect on the contamination index follows the order of Factor-1 > Factor-2 > Factor-3. The spatial distribution of the contamination index is used to classify the area into highly contaminated, moderately contaminated and uncontaminated zones. 相似文献
94.
95.
A method of correlation analysis within a spatially moving window was applied to two sets of epidemiological/geochemical data in Norway, (1) mortality/disability rates of multiple sclerosis (MS) versus atmospheric fallout of Mg and concentrations of Se in overbank sediment, and (2) incidence rates of malignant melanoma of the skin (MM) versus concentrations of Ca and K in overbank sediment. It appears that n = 17 observation sites within the moving window is a practical compromise between noise in the data at small values of n and a spatial resolution good enough to detect trends in the distribution patterns of the correlation coefficient. For MS versus Mg, MS versus Se and MM versus Ca the correlation coefficients are generally negative and depict systematic distribution patterns with anomalous clusters of sites with good correlation. For MS versus Se the correlation coefficients also form an additional cluster of positive coefficients. Tests with permutated data show that more than 70% of the negative correlation coefficients for MS versus Mg and for MM versus Ca are both significantly different from zero at p<0.05, while less than 15% of those for MS versus Se are significant at the same level. For MM versus K the correlation coefficients are randomly distributed and not significantly different from zero. The described correlations may be effects of confounders and do not per se indicate any causal relationships. However, further research based on these results may well lead to the identification of possible aetiological factors. 相似文献
96.
霍林河中游径流量序列的多时间尺度特征及其效应分析 总被引:7,自引:1,他引:7
霍林河是松嫩平原西部地区科尔沁、向海和查干湖湿地的重要补给水源。通过对其中游白云胡硕水文测站46a的年径流量序列的多时间尺度分析,探讨霍林河径流演变的近似周期性,识别霍林河径流变化对其下游洪泛湿地水源补给的规律,以及这种规律控制下的洪泛湿地环境演变。小波分析表明,霍林河白云胡硕水文站年径流序列主要存在3个尺度的周期变化,不同时间尺度下周期信号的强弱在时频域中的分布具有较强的局部特征,以大于30a尺度的年代际周期变化起主导作用,该尺度下,霍林河径流演变呈现出丰、枯、丰的交替振荡,下游洪泛湿地景观演变相应表现出阶段性特征,1990年代以前尤为突出。能量相对较弱的中、小时间尺度径流量周期性变化,与强烈的人类干扰活动相比,对下游洪泛湿地环境演变的作用效果不明显,突出表现在1990年代以后。 相似文献
97.
4种重要因素对柴油机颗粒物排放因子的量化影响研究 总被引:1,自引:0,他引:1
在发动机台架测试基础上,按照发动机排放阶段、油品种类、后处理装置和运行工况4种因素的不同,进行了24组测试,研究了颗粒物排放因子.同时,应用单因素敏感性分析,探究了发动机排放阶段和油品种类对颗粒物排放因子的影响;并运用多元线性回归分析,探讨了4种因素对颗粒物排放因子的影响力大小排序.结果显示:24组柴油机测试的颗粒物排放因子均值为(21.9±24.5) mg·kWh~(-1);使用国Ⅴ排放标准柴油机的颗粒物排放因子((14.7±5.6) mg·kWh~(-1))比国Ⅳ排放标准柴油机((19.4±16.4) mg·kWh~(-1))有所下降;国Ⅳ柴油、国Ⅴ柴油和混合柴油的颗粒物排放因子平均值分别为120.0、(11.8±1.0)和(11.5±1.3) mg·kWh~(-1),混合柴油颗粒物排放因子与国Ⅴ柴油相近,两者相比国Ⅳ柴油有明显下降;油品种类是影响颗粒物排放因子的第一大因素,后处理是影响颗粒物排放因子的第二大因素. 相似文献
98.
通过分析多承载索货运索道工作索的空间位置关系,在弹性悬链线计算方法的基础上,建立包括索道结构守恒方程和力平衡方程的非线性方程组,形成多承载索货运索道系统整体耦合计算方法。针对四承载索货运索道的典型设计工况,应用该方法完成承载索长度不一致情况下,货运索道的承载索张力变化分析。研究结果表明:多承载索货运索道承载索间的张力不平衡受索长偏差影响极大,而且不平衡效应与索长变化工况(索长偏差变化量、变化索的位置等)和载荷重量密切相关,多索索长不一致造成的张力不平衡使得承载索破断风险急剧增加。 相似文献
99.
管制疲劳是影响民航安全的重大隐患,准确检测疲劳状态是进行疲劳预警、降低疲劳风险的关键。提出应用支持向量机模型融合多生理参数和眼动指标进行管制疲劳检测,通过MP150多导生理记录仪与眼动仪,采集模拟管制试验中正常与剥夺睡眠状态下被试的试验数据,同时记录其Karolinska疲劳等级和操作绩效。结果表明,RR间期、LF/HF、快慢波比值、PERCLOS和扫视速度均与管制疲劳呈较强相关,利用支持向量机融合五项指标构建管制疲劳检测模型,对于五级疲劳度的识别准确率为78. 1%,判断正常组与剥夺睡眠组的准确率为94. 2%。 相似文献
100.
Maureen D. Correll Whitney A. Wiest Thomas P. Hodgman W. Gregory Shriver Chris S. Elphick Brian J. McGill Kathleen M. O'Brien Brian J. Olsen 《Conservation biology》2017,31(1):172-182
Coastal marshes are one of the world's most productive ecosystems. Consequently, they have been heavily used by humans for centuries, resulting in ecosystem loss. Direct human modifications such as road crossings and ditches and climatic stressors such as sea‐level rise and extreme storm events have the potential to further degrade the quantity and quality of marsh along coastlines. We used an 18‐year marsh‐bird database to generate population trends for 5 avian species (Rallus crepitans, Tringa semipalmata semipalmata, Ammodramus nelsonii subvirgatus, Ammodramus caudacutus, and Ammodramus maritimus) that breed almost exclusively in tidal marshes, and are potentially vulnerable to marsh degradation and loss as a result of anthropogenic change. We generated community and species trends across 3 spatial scales and explored possible drivers of the changes we observed, including marsh ditching, tidal restriction through road crossings, local rates of sea‐level rise, and potential for extreme flooding events. The specialist community showed negative trends in tidally restricted marshes (?2.4% annually from 1998 to 2012) but was stable in unrestricted marshes across the same period. At the species level, we found negative population trends in 3 of the 5 specialist species, ranging from ?4.2% to 9.0% annually. We suggest that tidal restriction may accelerate degradation of tidal marsh resilience to sea‐level rise by limiting sediment supply necessary for marsh accretion, resulting in specialist habitat loss in tidally restricted marshes. Based on our findings, we predict a collapse of the global population of Saltmarsh Sparrows (A. caudacutus) within the next 50 years and suggest that immediate conservation action is needed to prevent extinction of this species. We also suggest mitigation actions to restore sediment supply to coastal marshes to help sustain this ecosystem into the future. 相似文献