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21.
Inhibition of gap junctional intercellular communication (GJIC) is affiliated with tumor promotion process and it has been employed as an in vitro biomarker for evaluation of tumor promoting effects of chemicals. In the present study we investigated combined effects of anthropogenic environmental contaminants 2,2′,4,4′,5,5′-hexachlorobiphenyl (PCB 153) and fluoranthene, cyanotoxins microcystin-LR and cylindrospermopsin, and extracts of laboratory cultures of cyanobacteria Aphanizomenon gracile and Cylindrospermopsis raciborskii, on GJIC in the rat liver epithelial cell line WB-F344. Binary mixtures of PCB 153 with fluoranthene and the mixtures of the two cyanobacterial strains elicited simple additive effects on GJIC after 30 min exposure, whereas microcystin-LR and cylindrospermopsin neither inhibited GJIC nor altered effects of PCB 153 or fluoranthene. However, synergistic effects were observed in the cells exposed to binary mixtures of anthropogenic contaminants (PCB 153 or fluoranthene) and cyanobacterial extracts. The synergistic effects were especially pronounced after prolonged (6-24 h) co-exposure to fluoranthene and A. gracile extract, when mixture caused nearly complete GJIC inhibition, while none of the individual components caused any downregulation of GJIC at the same concentration and exposure time. The effects of cyanobacterial extracts were independent of microcystin-LR or cylindrospermopsin, which were not detected in cyanobacterial biomass. It provides further evidence on the presence of unknown tumor promoting metabolites in cyanobacteria. Clear potentiation of the GJIC inhibition observed in the mixtures of two anthropogenic contaminants and cyanobacteria highlight the importance of combined toxic effects of chemicals in complex environmental mixtures. 相似文献
22.
Erich Gebhart 《毒物与环境化学》2013,95(1-2):7-15
A very extensive and effective research in the fields of classical and molecular cytogenetics of cancer cells, during the past 10 years, has produced a rather concrete picture of the events and mechanisms rendering a normal cell a malignant one: Mutational changes in the control of so‐called cellular oncogenes play a fundamental role in cell transformation and tumor progression. These oncogenes are highly conservative and, therefore, important genes normally coding for a series of specific proteins particularly involved in growth control and differentiation processes. The most important alterations of these genes are: (1) Point mutations (e.g. base transitions) in essential base pairs of the respective proto‐oncogenes causing an uncontrolled expression of the latter, (2) translocations of specific chromosomal segments resulting in transfer of a proto‐oncogene from its normal (controlled) location into the area of highly active genes and by that in its activation, (3) amplification of DNA sequences including proto‐oncogenes which also can cause their over‐expression, (4) insertion of retroviral oncogenes into the DNA, (5) point mutations or deletions in “control genes” rendering the respective gene mutation homozygous or hemizygous. All these events are mutations in the strict sense the mutageneticist applies to the endpoints of his experimental studies. Above all, the fundamental importance of translocations and point mutations in the transformation process has clearly been evidenced by these data. Therefore, the design of experiments in mutagenicity testing should preferentially consider these types of mutations. Any mutagen, e.g. certain heavy metals or their compounds, inducing those types of mutations, must be considered suspicious not only concerning its mutagenicity in germ cells but also in somatic cells, and, by that, its carcinogenicity. 相似文献
23.
Exposure to inorganic arsenic from rice: a global health issue? 总被引:5,自引:0,他引:5
24.
Rauda Lúcia Mariani Sergio Silva Pereira Regiani Carvalho-Oliveira Paulo Hilário Nascimento Saldiva 《Environmental pollution (Barking, Essex : 1987)》2009,157(6):1767-1770
The present study was designed to explore the correlation between the frequency of micronuclei in Trad-MN, measured across 28 biomonitoring stations during the period comprised between 11 of May and 2 of October, 2006, and adjusted mortality rates due to cardiovascular, respiratory diseases and cancer in Sao José dos Campos, Brazil, an area with different sources of air pollution. For controlling purposes, mortality rate due to gastrointestinal diseases (an event less prone to be affected by air pollution) was also considered in the analysis. Spatial distribution of micronuclei frequency was determined using average interpolation. The association between health estimators and micronuclei frequency was determined by measures of Pearson's correlation. Higher frequencies of micronuclei were detected in areas with high traffic and close to a petrochemical pole. Significant associations were detected between micronuclei frequency and adjusted mortality rate due to cardiovascular diseases (r = 0.841, p = 0.036) and cancer (r = 0.890, p = 0.018). The association between mortality due to chronic obstructive pulmonary diseases was positive but did not reach statistical significance (r = 0.640, p = 0.172), probably because of the small number of events. Gastrointestinal mortality did not exhibit significant association with micronuclei frequency. Because the small number of observations and the nature of an ecological study, the present findings must be considered with caution and considered as preliminary. Further studies, performed in different conditions of contamination and climate should be done before considering Trad-MN in the evaluation of human health risk imposed by air pollutants. 相似文献
25.
中国肝癌与土壤环境中化学元素的相关性研究 总被引:13,自引:1,他引:13
利用土壤元素资料2069448个数据,肝癌死亡调查资料121080例,研究了肝癌死亡率与土壤环境中64个元素的相关性。结果表明,64个元素中有18种元素的与肝癌死亡率有关,同时得到了相应的等级相关系数。 相似文献
26.
癌症与土壤环境中锆元素的关系 总被引:2,自引:0,他引:2
利用土壤环境中锆元素资料 767个数据和癌症死亡调查资料 7870 80例 ,研究了癌症死亡率与人群生存区土壤环境中锆元素的关系。结果表明 :肝癌、肺癌、鼻咽癌、乳腺癌死亡率与锆元素有相关性 ,等级相关系数分别为 0 5 0 44 (P <0 0 0 5 )、0 3 3 99(P <0 0 5 )、0 3 164 (P <0 0 5 )、0 3 197(P <0 0 5 )。 相似文献
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Martí Nadal Marta Schuhmacher José L. Domingo 《Environmental science and pollution research international》2009,16(3):322-328
Background, aim, and scope To enforce the implementation of the Kyoto Protocol targets, a number of governmental/international institutions have launched
emission trade schemes as an approach to specify CO2 caps and to regulate the emission trade in recent years. These schemes have been basically applied for large industrial sectors,
including energy producers and energy-intensive users. Among them, cement plants are included among the big greenhouse gas
(GHG) emitters. The use of waste as secondary fuel in clinker kilns is currently an intensive practice worldwide. However,
people living in the vicinity of cement plants, where alternative fuels are being used, are frequently concerned about the
potential increase in health risks. In the present study, a cost–benefit analysis was applied after substituting classical
fuel for sewage sludge as an alternative fuel in a clinker kiln in Catalonia, Spain.
Materials and methods The economical benefits resulting in the reduction of CO2 emissions were compared with the changes in human health risks due to exposure to polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and carcinogenic metals (As, Cd, Co, and Cr) before and after using sewage sludge to
generate 20% of the thermal energy needed for pyro-processing. The exposure to PCDD/Fs and metals through air inhalation,
soil ingestion and dermal absorption was calculated according to the environmental levels in soil. The carcinogenic risks
were assessed, and the associated cost for the population was estimated by considering the DG Environment’s recommended value
for preventing a statistical fatality (VPF). In turn, the amount of CO2 emitted was calculated, and the economical saving, according to the market prices, was evaluated.
Results The use of sewage sludge as a substitute of conventional energy meant a probability cancer decrease of 4.60 for metals and
a cancer risk increase of 0.04 for PCDD/Fs. Overall, a net reduction of 4.56 cancers for one million people can be estimated.
The associated economical evaluation due to the decreasing cancer for 60,000 people, the current population living near the
cement plant, would be of 0.56 million euros (US$ 0.83 million). In turn, a reduction of 144,000 tons of CO2 emitted between 2003 and 2006 was estimated. Considering a cost of 20 euros per ton of CO2, the global saving would be 2.88 million euros (US$ 4.26 million).
Discussion After the partial substitution of the fuel, the current environmental exposure to metals and PCDD/Fs would even mean a potential
decrease of health risks for the individuals living in the vicinity of the cement plant. The total benefit of using sewage
sludge as an alternative fuel was calculated in 3.44 million euros (US$ 5.09 million). Environmental economics is becoming
an interesting research field to convert environmental benefits (i.e., reduction of health risks, emission of pollutants,
etc.) into economical value.
Conclusions The results show, that while the use of sewage sludge as secondary fuel is beneficial for the reduction in GHG emissions,
no additional health risks for the population derived from PCDD/F and metal emissions are estimated.
Recommendations and perspectives Cost–benefit analysis seems to be a suitable tool to estimate the environmental damage and benefit associated to industrial
processes. Therefore, this should become a generalized practice, mainly for those more impacting sectors such as power industries.
On the other hand, the extension of the study could vastly be enlarged by taking into account other potentially emitted GHGs,
such as CH4 and N2O, as well as other carcinogenic and non-carcinogenic micropollutants. 相似文献
29.
Mark K. Goldstein Salvador R. Bozzo Robert Malone Fernando Galdos Walter Sevian Donald Goellner 《Environmental management》1979,3(5):447-460
The data base for each process of the nuclear fuel cycle has been updated as a part of the Committee on Nuclear and Alternative Energy Systems (CONAES) at Brookhaven National Laboratory (BNL). The BNL Energy System Network Simulator (ESNS) was modified to accommodate the new data, and methodology was developed for estimating population dose and health effects resulting from atmosphere releases of radioactive materials from the nuclear fuel cycle.Estimates of population dose and health effects were made using these new CONAES emission data and the new model for three scenarios out to the year 2000: (1) no reprocessing; (2) reprocessing, 1-year cooling; and (3) reprocessing, 5-year cooling. Results indicate that radon emissions from mining and milling of uranium bearing ores will have greater impacts than any other component in the open nuclear fuel cycle. The estimated number of health effects will depend, to a large extent, on the lung model mechanism assumed to induce cancer; i.e., either the smeared or the unsmeared model. The smear model and the linear relationship predict for scenario 1, 630; for scenario 2, 949; and for scenario 3, 854 lung cancers, respectively, using the new CONAES data.Epidemiologic data from six United States counties were correlated using a new statistical model (described in the text) in order to test the validity of the lung model and the linear relationship. Results do not support the high lung cancer correlations expected from the unsmear model and the linear relationship; therefore, it is concluded that low-dose mechanisms may be different from those developed from high-dose data. The best place to look for effects of low-dose radiation may be the less developed countries because of a reduction in the noise level caused by chemical pollutants. 相似文献
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