我国海洋环境污染监测质量保证的回顾与展望

我国海洋环境污染监测质量保证的发展历史可大致分为三个阶段：孕育阶段（１９７２～１９７７年）起步阶段（１９７８～１９８３年）和发展阶段（１９８４～）。各个阶段有不同的特色和侧重点，１９７８年前主要探索与污染物质的分析方法，１９８４年后是监测质量保证工作进入管理时期。     

分光光度法测定染色废水的色度

为消除测定染色废水色度的主观误差，采用分光光度法测定染色废水的色度，与稀释倍数法相比，具有精确，重现性好，适用范围广等特点，ＰＨ值对色度的测定有明显影响，控制ＰＨ值为７．６０，测定色度具有可比性。     

合成洗涤剂对小鼠诱变性研究

连续５天腹腔注射同一剂量（１／５ＬＤ５０）的合成洗涤剂，取小鼠骨髓细胞测定嗜多染色红细胞的微核率，研究表明，３种合成洗涤剂（加大香洗衣粉，洁牌餐具洗涤剂，恩威高级餐具洗洁精）使小鼠微核率有所增高，但恩威，洁牌餐具洗涤剂与对照无显著性差异。     

The interaction between physical and social-psychological factors in indoor environmental health

Indoor environmental health is now recognized as an important factor in preventing respiratory health problems in the United States. It is also a concern in Canada due to the amount of time that Canadians spend indoors because of cold weather and the potential for increased time indoors during the summer if theclimate warms. The negative health effects are often labeled assick building syndrome, but diagnosing a building or itsoccupants as sick is complicated by the variety of symptoms, thepresence of chronic versus acute symptoms and social andpsychological (socio-psychological) factors that may reduce theeffectiveness of an engineering solution. As a case study, thecontribution of various factors to indoor environmental health,in three buildings at the University of Toronto, was examinedusing five different methods. The results indicate that theinhabitants of the buildings consider features other than airquality in considering building health such as design,maintenance, funding cuts and socio-psychological factors.     

汕头港湾附近水域潮流特征和污染物扩散的数值计算 Ⅰ汕头港湾附近水域潮流特征及数值模拟

汕头港湾附近水域的潮流特征，由于拦沙堤的建成及港池附近河道变窄而发生了一些变化。本文在取得现场实测资料的基础上，采用沿深度平均的二维浅水潮波方程，对该水体的潮流场进行了数值模拟计算，重现出潮流场在一个潮周期中的变化过程，分析潮流对污染扩散的作用。     

汕头港水域温排水热扩散的三维数值模拟

本文建立了汕头港水域温排水扩散的三维数学模型，并采用特征差分方法求其解，对该法在三维情况下的稳定作了推导，给出了判断公式，上述模型被应用于汕头热电厂废热水排放的环境影响评价中，实例计算表明，该模型算法程序简单，计算结果合理。     

Prenatal diagnosis of mosaic 4p – in a fetus with trisomy 21

Mosaicism for the Wolf-Hirschhorn syndrome, del(4)(p16), is extremely rare and has not been reported in association with a numerical chromosome abnormality. We report the prenatal diagnosis of mosaic del(4)(p16) and non-mosaic trisomy 21 in a 16-week female fetus. The pregnancy ended in spontaneous abortion at 34 weeks secondary to fetal demise. The fetus had features of both 4p – and trisomy 21.     

Prenatal exclusion of stickler syndrome

Stickler syndrome is an autosomal dominant disorder of the connective tissue which includes ocular and systemic manifestations. We report on a large kindred in which we were able to demonstrate very tight linkage between the disease and the type II collagen gene (COL2A1) (LOD score 3·91 at θ=0). In a family in which the father and one of his daughters were severely affected, DNA analysis from a chorionic villus sample demonstrated that the fetus possessed the normal allele of COL2A1. Thereafter a normal child was born.     

Incremental cost-effectiveness of incorporating oestriol evaluation in down syndrome screening programmes

As screening for Down syndrome becomes increasingly sophisticated, it is important to evaluate the newer technologies in terms of their cost-effectiveness. One recent addition to Down syndrome screening programmes is maternal serum unconjugated oestriol (uE₃), especially when used in conjunction with maternal serum α-fetoprotein and human chorionic gonadotropin. Using assumptions used in a California proposal to justify an expanded screening programme for Down syndrome, we calculated both the average and the incremental cost-effectiveness of adding uE₃. Using the base case assumptions, including an $8 fee for the uE₃, the incremental cost-effectiveness of adding uE₃ to the proposed California programme is $119 100 per case detected, a value that compares favourably with other Down syndrome screening programmes. The sensitivity analysis supports this conclusion over a wide range of assumptions. However, because of the uncertainty with some key data, it is still too early to fully support the inclusion of uE₃ in Down syndrome screening programmes.     

Prenatal diagnosis for huntington's disease: A molecular and psychological study

Two linked probes were used to determine the Huntington's disease status of the fetus conceived by a woman affected with the condition. The fetus was found to be unaffected with a certainty of 97 per cent. The ethical issues associated with presymptomatic testing were avoided since the mother presented with initial symptoms of Huntington's disease, but other psychological and ethical issues arose. The concerns of an affected woman planning a pregnancy, and the dilemmas involved in decision-making regarding prenatal diagnosis and possible selective abortion were exposed and explored with the patient and her husband.