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602.
Decabromodiphenyl ether (BDE-209) is a prevalent polybrominated diphenyl ether (PBDE) congener known to have neurotoxicity. Effects of BDE-209 on Neuro-2a cells were performed in the present study and the possible apoptotic pathway was discussed. Results indicated that BDE-209 induced Neuro-2a cell apoptosis, increased the protein expression of Fas and Fas-associated death domain-containing protein (FADD) and activated the caspase-8 and -3 activities in a concentration-dependent manner, inferring the death-receptor pathway was involved in the apoptotic process. Meanwhile, BDE-209 exposure increased the Bax/Bcl-2 ratio and decreased the cellular mitochondrial membrane potential (MMP) which led to cytochrome C released to the cytoplasm. The intracellular caspase-9 was elevated simultaneously, which caused downstream caspase cascade and triggered cell apoptosis. Moreover, BDE-209 exposure increased cellular reactive oxygen species (ROS) level in a concentration-dependent manner and the addition of N-acetyl-l-cysteine (NAC), known as ROS scavengers, obviously reduced the apoptotic rate and a positive relationship was observed between the degree of apoptosis blocking and the loss of MMP and ROS production. We thus concluded that BDE-209 induced Neuro-2a cell apoptosis via the combination of the death-receptor signaling pathway and the mitochondrial signaling pathway. The elevated ROS production was considered to magnify the intracellular apoptosis signal and played a crucial role in apoptosis of Neuro-2a cells induced by BDE-209. 相似文献
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604.
在一些环境污染型工程项目中,做好农村移民的安置规划工作尤为重要。借助世行贷款项目,通过持续的实际调研,以梅城垃圾填埋场为例,介绍了项目的建设主要内容及影响。从征地补偿安置、农村住宅房屋拆迁安置及弱势群体及妇女权益保护三个方面论述了农村移民生产生活安置方式。基于此,总结出了以下四个结论:(1)严格遵守相关法律法规、(2)征迁过程与安置工作相协调、(3)合理补偿,适当调整、(4)强化机构建设和人员能力培养。并提出了四条合理化建议。 相似文献
605.
Sandra Huning 《Local Environment》2018,23(9):907-911
This Translations contribution presents the 10th issue of the series Frei.Räume (in English: Free spaces), edited by the German Feminist Organisation of (female) Planners and Architects (FOPA) in 1998. The issue was titled “New roads – new goals. Positions of feminist planning” and reflected the contemporary discussions on the state of the art of feminism, gender and planning. While progress was recognized, many authors felt uncomfortable with the ways that feminist concerns had been implemented into planning, and they were looking for ways forward. Among the authors were the most important protagonists of the debates at the time. Looking at the issue today, it becomes clear that many concerns are as up to date as they were in the late 1990s, although circumstances have changed. The paper argues that it is worthwhile to pay attention to these feminist debates in order to develop future strategies for feminism in planning. 相似文献
606.
This paper evaluates the planning competences required to enact a managed transition to sustainability at the municipal level for cities facing population, economic and employment decline. Drawing on the ‘shrinking cities’ literature, we argue consolidation of the built environment can become a focal point for sustaining citizen welfare when transitioning cities that are facing decline, especially those previously reliant on resource industries. We evaluate the former coal mining city of Yubari, Japan, which is developing a consolidated urban form with the aim of creating a ‘sustainable’ future city. Findings from interviews and content analysis of Yubari’s planning policy indicate, however, that to translate ‘shrinking’ a city into a managed transition, spatial planning must be accompanied by a wider range of social policy measures and strong cross-sectoral engagement. We also caution that the unique geographical and political context of Yubari mean its model may not be directly replicable in other contexts. 相似文献
607.
608.
Brent D. Moyle Char-lee Moyle Alexandra Bec 《Journal of Environmental Policy & Planning》2018,20(1):31-44
The Great Barrier Reef (GBR) is a natural asset of global significance, spanning 2600?km’s along the Australian coastline. On the southern tip of the GBR is the Gladstone region, where high levels of industrial activity have been juxtaposed with the natural wonder, and World Heritage Listed, GBR. Given these competing local priorities, this research explores local perceptions of the GBR and its management. Exploratory analysis of 38 interviews with residents and stakeholders from Gladstone revealed a potential incongruence between environmental concern and support for more stringent management of the tourism and resources sectors on the GBR. A responsibility–accountability framework (RAF) for managing the use and protection of the GBR is developed by drawing on current theoretical frameworks and the results of the interviews. Importantly the framework highlights the importance of business responsibility combined with monitoring and control mechanisms to ensure accountability and to deliver transparency, education and partnership. Future research should apply the RAF for testing and application in other marine World Heritage Area contexts. 相似文献
609.
Per Schubert Nils G. A. Ekelund Thomas H. Beery Christine Wamsler K. Ingemar Jönsson Andreas Roth 《Journal of Environmental Policy & Planning》2018,20(3):298-312
While ecosystem-based planning approaches are increasingly promoted through international and national policies, municipalities are still struggling with translating them into practice. Against this background, this paper aims to increase the knowledge of current advances and possible ways to support the implementation of the ecosystem services (ES) approach at the municipal level. More specifically, we analyze how ES have been integrated into comprehensive planning within the municipality of Malmö in Sweden over the last 60 years, a declared forerunner in local environmental governance. Based on a content analysis of comprehensive plans over the period 1956–2014 and interviews with municipal stakeholders, this paper demonstrates how planning has shifted over time toward a more holistic view of ES and their significance for human well-being and urban sustainability. Both explicit and implicit applications of the ES concept were found in the analyzed comprehensive plans and associated programs and projects. Our study shows how these applications reflect international, national, and local policy changes, and indicates how municipalities can gradually integrate the ES approach into comprehensive planning and facilitate the transition from implicit to more explicit knowledge use. 相似文献
610.
Sophie C. Rudolf Felix Kienast Anna M. Hersperger 《Journal of Environmental Planning and Management》2018,61(3):474-492
Urban growth is a key issue for spatial planning as it influences urban patterns and disrupts open landscapes. To effectively steer urban growth towards compact urban forms, many growth-management policies have been developed over recent decades. However, few studies have assessed how municipal policy mixes have evolved over time. In our representative Swiss-wide survey, we evaluated the prevalence and the time of introduction of 18 policies. Our results indicate that large municipalities use a broad range of reinforcing policies over decades. In contrast, small municipalities mostly rely on conventional land-use regulations. The lack of innovative, incentive-based policies casts doubt on small municipalities' ability to effectively manage urban growth. However, our analyses reveal recent efforts by small municipalities to diversify approaches to growth management and adopt innovative policies. These efforts should be supported by guiding small municipalities in their policy choices, and providing support to those lacking planning capacity. 相似文献