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411.
Metabolism of acetaminophen (paracetamol) in plants—two independent pathways result in the formation of a glutathione and a glucose conjugate 总被引:1,自引:0,他引:1
Christian Huber Bernadett Bartha Rudolf Harpaintner Peter Schröder 《Environmental science and pollution research international》2009,16(2):206-213
Background, aim, and scope Pharmaceuticals and their metabolites are detected in the aquatic environment and our drinking water supplies. The need for
high quality drinking water is one of the most challenging problems of our times, but still only little knowledge exists on
the impact of these compounds on ecosystems, animals, and man. Biological waste water treatment in constructed wetlands is
an effective and low-cost alternative, especially for the treatment of non-industrial, municipal waste water. In this situation,
plants get in contact with pharmaceutical compounds and have to tackle their detoxification. The mechanisms for the detoxification
of xenobiotics in plants are closely related to the mammalian system. An activation reaction (phase I) is followed by a conjugation
(phase II) with hydrophilic molecules like glutathione or glucose. Phase III reactions can be summarized as storage, degradation,
and transport of the xenobiotic conjugate. Until now, there is no information available on the fate of pharmaceuticals in
plants. In this study, we want to investigate the fate and metabolism of N-acetyl-4-aminophenol (paracetamol) in plant tissues using the cell culture of Armoracia rusticana L. as a model system.
Materials and methods A hairy root culture of A. rusticana was treated with acetaminophen in a liquid culture. The formation and identification of metabolites over time were analyzed
using HPLC-DAD and LC–MSn techniques.
Results With LC–MS technique, we were able to detect paracetamol and identify three of its metabolites in root cells of A. rusticana. Six hours after incubation with 1 mM of acetaminophen, the distribution of acetaminophen and related metabolites in the
cells resulted in 18% paracetamol, 64% paracetamol–glucoside, 17% paracetamol glutathione, and 1% of the corresponding cysteine
conjugate.
Discussion The formation of two independently formed metabolites in plant root cells again revealed strong similarities between plant
and mammalian detoxification systems. The detoxification mechanism of glucuronization in mammals is mirrored by glucosidation
of xenobiotics in plants. Furthermore, in both systems, a glutathione conjugate is formed. Due to the existence of P450 enzymes
in plants, the formation of the highly reactive NAPQI intermediate is possible.
Conclusions In this study, we introduce the hairy root cell culture of A. rusticana L. as a suitable model system to study the fate of acetaminophen in plant tissues. Our first results point to the direction
of plants being able to take up and detoxify the model substrate paracetamol. These first findings underline the great potential
of using plants for waste water treatments in constructed wetlands.
Recommendations and perspectives This very first study on the detoxification of a widely used antipyretic agent in plant tissues again shows the flexibility
of plant detoxification systems and their potential in waste water treatment facilities. This study covers only the very first
steps of acetaminophen detoxification in plants; still, there is no data on long-term exposure as well as the possible impact
of pharmaceuticals on the plant health and stress defense. Long-term experiments need to be performed to follow the fate of
acetaminophen in root and leaf cells in a whole plant system, and to evaluate possible usage of plants for the remediation
of acetaminophen from waste water. 相似文献
412.
氧化/吸附/混凝协同工艺处理焦化废水生物处理出水的过程及效果分析 总被引:1,自引:0,他引:1
针对焦化废水生物处理出水中继续存在多种有机污染物而影响达标及存在安全隐患的现状,基于废水中有机物的物理化学特性,构建了氧化/吸附/混凝的深度处理过程。在NaC lO投加量为40 mg/L,AC投加量为500 mg/L,PFS投加量为300 mg/L,反应时间为0.5 h,以及pH为7.0的最佳条件下,先氧化后吸附混凝,该过程可以实现COD去除率为75%以上,色度去除率80%以上,处理后的水样其COD值与色度值分别下降到60 mg/L及20倍以下;通过GC/MS方法分析处理前后水样中的有机物组分,发现水样中大部分单环芳香族化合物和多环芳香族化合物,部分含氮杂环化学物、有机氯化物以及溴化物被去除,但是,长链烷烃和部分芳香烃继续保留。研究结果证明了氧化/吸附/混凝协同工艺的效果与焦化废水生物出水中有机污染物的分子结构、存在形态形成构效关系,催化作用与氧化作用的协同是获得高效去除率的关键。 相似文献
413.
Pareja L Pérez-Parada A Agüera A Cesio V Heinzen H Fernández-Alba AR 《Chemosphere》2012,87(8):838-844
Quinclorac (QNC) is an effective but rather persistent herbicide commonly used in rice production. This herbicide presents a mean persistence in the environment so its residues are considered of environmental relevance. However, few studies have been conducted to investigate its environmental behavior and degradation. In the present work, direct photolysis and TiO2 photocatalysis of the target compound in ultrapure and paddy field water were investigated. After 10 h photolysis in ultrapure water, the concentration of QNC declined 26% and 54% at 250 and 700 W m−2, respectively. However, the amount of quinclorac in paddy field water remained almost constant under the same irradiation conditions. QNC dissipated completely after 40 min of TiO2 photocatalysis in ultrapure water, whereas 130 min were necessary to degrade 98% of the initial concentration in paddy field water.Possible QNC photolytic and photocatalytic degradation pathways are proposed after structure elucidation of the main transformation products, through liquid chromatography-electrospray ionization-quadrupole time-of-flight mass spectrometry and exact mass measurements. Pyridine ring hydroxylation at C-9 followed by ring opening and/or oxidative dechlorination were the key steps of QNC degradation. 相似文献
414.
Cigarette smoke is a risk factor for human health, and many studies were conducted to investigate its adverse effects on humans and other mammals. However, since large amounts of cigarette products are produced and consumed, it is possible that tobacco chemicals can end up in aquatic environments through several routes, thus influencing aquatic organisms. In this study, the presence of tobacco-specific nitrosamine (TSNA), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), in aquatic environment was demonstrated. Since toxic effects on and distribution patterns of tobacco chemicals in aquatic organisms were rarely studied, after results of an acute toxicity pretest were obtained, experiment was conducted to investigate the bioaccumulation pattern of NNK and distribution patterns of its metabolites, mainly 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), in NNK-treated freshwater planarians, Dugesia japonica. Results from in vivo and in vitro studies showed that NNK was readily converted to NNAL through the carbonyl reduction in bodies of NNK-treated planarians. Tissue concentrations of both chemicals increased in time- and dose-dependent manners. Furthermore, we examined the end products of NNK/NNAL α-hydroxylation in NNK-treated planarians, but only 1-(3-pyridyl)-1,4-butanediol was detected, suggesting that NNK metabolism in planarians partially differs from that in mammalian systems. This is the first report on NNK metabolism in an aquatic organism and can be used as a foundation for developing freshwater planarians as a new in vivo model for the study of NNK toxicology in the future. 相似文献
415.
A HPLC-MS/MS method is presented for the simultaneous determination of frequently used artificial sweeteners (ASs) and the main metabolite of aspartame (ASP), diketopiperazine (DKP), in environmental water samples using the direct-injection (DI) technique, thereby achieving limits of quantification (LOQ) of 10 ng L−1. For a reliable quantification of ASP pH should be adjusted to 4.3 to prevent formation of the metabolite. Acesulfame (ACE), saccharin (SAC), cyclamate (CYC) and sucralose (SUC) were ubiquitously found in water samples. Highest concentrations up to 61 μg L−1 of ACE were found in wastewater effluents, followed by surface water with concentrations up to 7 μg L−1, lakes up to 600 ng L−1 and groundwater and tap water up to 70 ng L−1. The metabolite DKP was only detected in wastewater up to 200 ng L−1 and at low detection frequencies. 相似文献
416.
Organosolv lignin was treated with ethanol at sub/supercritical temperatures (200, 275, and 350 °C) for conversion to low molecular phenols under different reaction times (20, 40, and 60 min), solvent-to-lignin ratios (50, 100, and 150 mL g−1), and initial hydrogen gas pressures (2 and 3 MPa). Essential lignin-degraded products, oil (liquid), char (solid), and gas were obtained, and their yields were directly influenced by reaction conditions. In particular, concurrent reactions involving depolymerization and recondensation as well as further (secondary) decomposition were significantly accelerated with increasing temperature, leading to both lignin-derived phenols in the oil fraction and undesirable products (char and gas). 相似文献
417.
Hrönn Jörundsdóttir Karin Löfstrand Jörundur Svavarsson Anders Bignert Åke Bergman 《Chemosphere》2013
Data on distribution, concentration and trends of polybrominated diphenyl ethers (PBDEs) and hexabromocyclododecanes (HBCDs) is scarce in biota from the sub-Arctic region of the Atlantic. The present study is an investigation on PBDE and HBCD concentrations in eggs from seven marine bird species from Iceland, i.e. common eider (Somateria mollissima), arctic tern (Sterna paradisaea), guillemot (Uria aalge), fulmar (Fulmarus glacialis), lesser black-backed gull (Larus fuscus), great black-backed gull (Larus marinus) and great skua (Stercorarius skua). Concentrations of sum PBDEs ranged from 44 ng g−1 fat in eider eggs to 2400 ng g−1 fat in great skua eggs. The contribution of different PBDE congeners to the sum concentration differed between species. Concentration of HBCDs (sum of α−,β− and γ−HBCD) ranged from 1.3 ng g−1 fat in arctic tern eggs to 41 ng g−1 fat in great black-backed gull. PCA on PBDE and HBCD shows different trends between the two BFR groups, further indicating different sources/usage. Investigations on any potential health or population effects of environmental pollutants on the great skua are advised since both the PBDE and HBCD concentrations are high. 相似文献
418.
Ana Aguilera Antonio Valverde Antonio Valverde-Monterreal Luis Garcia-Fuentes Mourad Boulaid 《Journal of environmental science and health. Part. B》2013,48(8):541-549
Derivatization of cyprodinil with different reagents and solvents has been evaluated to improve the GC/MS characterization of this fungicide. After assessing some preliminary acylation and silylation reactions, derivatization with anhydrous heptafluorobutyric anhydride (HFBA) was selected as the best derivatization option for cyprodinil. The HFBA-cyprodinil derivative was clearly identified and characterized by GC/MS (ion-trap). The spectrum of the HFBA derivative of cyprodinil was characterized by the base peak, 252 m/z ion, and two other ions with relative abundances of 5% (224 m/z ion) and 4% (420 m/z molecular ion). Conversion rates in the range of 83–92% were obtained when 0.1–1 μg cyprodinil were derivatized in vial without solvent at 25ºC temperature for 120 min, with 5 μL HFBA and 5 μL pyridine. Simultaneous extraction-derivatization of cyprodinil in supercritical carbon dioxide was only achieved when no modifier was present, but conversion/recovery rates obtained in the replicate experiments carried out with 15 mL supercritical carbon dioxide at 50°C and 200 atm (n = 5), 300 atm (n = 7), and 400 atm (n = 5) were no reproducible (RSD > 50%) and ranged between 10% and 45% (related to the signal obtained for derivatization in vial). 相似文献
419.
Angela Santilio Patrizia Stefanelli Roberto Dommarco 《Journal of environmental science and health. Part. B》2013,48(6):584-590
A fast, simple and inexpensive method has been developed for the analysis of phenoxy acid herbicides: 2,4-dichlorophenoxyacetic acid (2,4-D), 4-chloro-2-methylphenoxyacetic acid (MCPA), 2-(4-chloro-o-tolyloxy)propionic acid (MCPP), 2-(4-aryloxyphenoxy)propionic acid (Fluazifop) and 2-(4-aryloxyphenoxy)propionic acid (Haloxyfop) in carrots and apples by liquid chromatography coupled to triple quadrupole mass spectrometry (LC/MS/MS). The compounds were analyzed by QuEChERS (quick, easy, cheap, effective, rugged, safe) methodology without cleanup. The recoveries were performed at two spiked levels (0.05 and 0.5 mg/kg) for both matrices with six replicates for each level. The mean recoveries ranged from 70–92% for both apples and carrots. The precision of the method expressed as relative standard deviation (RSD%) was found to be in the range 3–15%. For all compounds, good linearity (r2 > 0.99) was obtained over the range of concentration from 0.05 μ g/mL to 0.5 μ g/mL, corresponding to the pesticide concentrations of 0.05 mg/kg and 0.5 mg/kg, respectively. The determination limits (LOQs) ranged from 0.01 ng/mL to 1.3 ng/mL in solvent, whereas, the LOQs calculated in matrix ranged from 0.05 ng/g to 21.0 ng/g for apples and from 0.06 ng/g to 10.2 ng/g for carrots. The developed methodology combines the advantages of both QuEChERS and LC/MS/MS producing a very rapid, sensitive and cheap method useful for the routine analytical laboratories. 相似文献
420.
采用铂金坩蜗熔融、银坩埚熔融和盐酸直接溶解方法测定了石灰石中多组分的含量。并同时使用ICP测定石灰石中SiO2、Al2O3、Fe2O3的成分。研究结果表明:在测定石灰石中CaO、MgO和Fe2O3含量时,采用盐酸直接溶解方法,具有方法简单、分析快速的优点,且准确度能达到要求;在测定石灰石中CaO、MgO、SiO2、Al2O3,和Fe2O3含量时,采用银坩埚代替铂金坩埚熔样,具有成本低的优点,且准确度亦能达到要求;采用ICP测定标准石灰石样的SiO2、Al2O3和Fe2O3组分具有快速、简单和准确度高的特点。 相似文献