Fetoplacental discrepancy involving structural abnormalities of chromosome 8 detected by prenatal diagnosis

We describe the finding of three cell lines involving different structural abnormalities of chromosome 8 detected in a prenatal diagnosis. Chorionic villi sampling (CVS) was performed on a pregnant woman because of advanced maternal age. Semidirect cytogenetic analysis showed a mos46,XX,i(8q)/46,XX,del(8)(p11.2) karyotype, confirmed by fluorescence in situ hybridization (FISH). Amniocentesis was subsequently performed, and the karyotype obtained was 46,XX,dup(8)(p23p11.2). The pregnancy was terminated; pathologic findings included clubfeet, clenched left hand, subcutaneous edema and bilateral hydrocephalus. Molecular studies using chromosome 8 microsatellites performed on parents' blood and fetal tissues revealed a maternal meiotic origin of the inv dup(8p) with deletion of the distal p23 region and duplication of the remaining 8p. We propose a model to explain the cytogenetic findings, which includes a first maternal meiotic error giving rise to a large dicentric isochromosome 8 present in the ovum, a second error in one of the first zygote divisions with misdivision of the dicentric 8 giving rise to a cell line with del(8p) confined to the trophoblast and another cell line with inv dup(8p) confined to the fetal tissue and a third error in the trophoblast giving rise to a further cell line with isochromosome 8q. Copyright © 2003 John Wiley & Sons, Ltd.     

信息融合技术在锅炉故障诊断中的应用

为满足锅炉故障诊断的要求，用信息融合技术，提出了具有数据挖掘功能的锅炉故障诊断系统的一般模型。在对锅炉故障诊断中的信息进行分类的基础上，详细阐述了模型中各功能模块的作用以及它们之间的层次关系，并提出了模型中关键技术的实现方法。实例分析表明，信息融合技术用于锅炉故障诊断对提高诊断的可靠性和准确性有重要作用。     

动态主逻辑图--一种改进的安全风险建模方法

用主逻辑图,可以比较直观地建立起复杂系统的安全风险模型,但是这种模型运用的是布尔代数理论,所以无法模拟具有动态行为的系统.动态主逻辑图就是在主逻辑图的基础上,运用模糊数学（逻辑）的理论,分析复杂系统中的动态行为.介绍了动态主逻辑图的8种基本形态,并以利用动态主逻辑图对系统进行全面诊断和描述系统的部分失效的行为为例,简要说明了动态主逻辑图的新特点.     

恐怖内心思想的智能阅读车(IRV)开发研究

近年来 ,恐怖袭击事件威胁着城市公共安全 ,给人们的精神和心理造成极大的创伤和痛苦 ,已引起各国政府、各大媒体的广泛关注。笔者分析了城市公共安全的特点 ,研制了恐怖内心思想的智能阅读车 (IRV) ,通过对进入公共场所的人群进行快速 (数秒内 )检测人体生理参数 (3项指标 ) ,阅读人群的心理、生理、行为特征 ,快速地识别出恐怖分子 ,解决了安全预警滞后的问题 ,建立公共安全的常规通道 (或非常规通道 )。研究与开发的目的是从传统的被动防范转变到主动预控 ,为解决国内外防恐和反恐难题提供了一种新方法。     

Ultrasound demonstration of masses in a 15 week fetus: Hydrops in a fetus with umbilical cord occlusion

A fetal abnormality detected at 15 weeks by ultrasound consisted of cystic appearing masses in the neck and back region. The differential diagnosis included gonadal dysgenesis (Turner's syndrome) with cystic hygroma, neural tube defect, e.g. encephalocele or meningomyelocele, and fetal hydrops. Intrauterine fetal demise occurred at 17 weeks. The fetus had marked edema possibly related to umbilical cord occlusion.     

Temporal changes in the utilization of amniocentesis for prenatal diagnosis by women of advanced maternal age, 1976–1983

Utilization of amniocentesis for prenatal diagnosis because of the indication of advanced maternal age (≥ 35 years at delivery) was examined in the population of B.C. over an 8-year period (1976–1983). As of 1983, approximately one out of three eligible women (≥ 35 years at delivery) is having the test. In the older group (≥ 38 years at delivery) approximately one out of two eligible women is having the test. The data do not indicate that the proportion of eligible women having amniocentesis has reached a plateau; utilization is continuing to increase. It appears that prenatal diagnosis is an ethically acceptable alternative for a large proportion of the population.     

珠江口西岸海水入侵现状调查分析

文章在珠江口西岸珠海、中山两市11个海水入侵观测站位一年多地下水实测分析数据的基础上,结合该区域水文气象、地质构造等背景资料,对该区域地下水受海水影响的现状及原因进行了分析,结果表明珠江口西岸地区由于河网密布、降水量大、地下水位高,地下水限制开采管理严格,开采量小,地下水基本处于原始状态,未受海水的侵染,地下水未对地表...