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101.
Ken Kin Lam Yung Pengfei Fu Yufei Zhao Chuan Dong Zongwei Cai Ruijin Li 《环境科学学报(英文版)》2022,34(12):25-40
Fine particulatematter (PM2.5) is associated with increased risks of Alzheimer’s disease (AD),yet the toxicologicalmechanisms of PM2.5 promoting AD remain unclear. In this study,wildtype
and APP/PS1 transgenic mice (AD mice) were exposed to either filtered air (FA) or PM2.5 for eight weeks with a real-world exposure system in Taiyuan, China (mean PM2.5 concentration
in the cage was 61 μg/m3). We found that PM2.5 exposure could remarkably aggravate AD mice’s ethological and brain ultrastructural damage, along with the elevation of the pro-inflammatory cytokines (IL-6 and TNF-α), Aβ-42 and AChE levels and the decline of ChAT levels in the brains. Based on high-throughput sequencing results, some differentially expressed (DE) mRNAs and DE miRNAs in the brains of AD mice after PM2.5 exposure were screened.Using RT-qPCR, seven DEmiRNAs (mmu-miR-193b-5p, 122b-5p, 466h-3p, 10b-5p, 1895, 384–5p, and 6412) and six genes (Pcdhgb8, Unc13b, Robo3, Prph, Pter, and Tbata)
were evidenced the and verified. Two miRNA-target gene pairs (miR-125b-Pcdhgb8 pair and miR-466h-3p-IL-17Rα/TGF-βR2/Aβ-42/AChE pairs) were demonstrated that they were more
related to PM2.5-induced brain injury. Results of Gene Ontology (GO) pathways and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways predicted that synaptic and postsynaptic
regulation, axon guidance, Wnt, MAPK, and mTOR pathways might be the possible regulatory mechanisms associated with pathological response. These revealed that PM2.5-
elevated pro-inflammatory cytokine levels and PM2.5-altered neurotransmitter levels in AD mice could be the important causes of brain damage and proposed the promising miRNA
andmRNA biomarkers and potentialmiRNA-mRNA interaction networks of PM2.5-promoted AD. 相似文献
102.
103.
Recent research has explored the role of environmental inequalities in explaining health disparities, especially in urban environments. This paper investigates the role of the landlord in shaping indoor environmental injustices. Specifically, we rely on interview data from low-income parents in South Phoenix, AZ, with elementary-aged children with asthma. We found families living in poor quality rental housing that impacted children's breathing. Landlords were directly involved in keeping the homes in poor condition, even when asked by the tenant to fix the property, and immigrants were especially at risk. In general, relationships between landlords and tenants were unequal and coloured by the tenant's poverty and fears of eviction. Among the immigrant tenants, many had accompanying fears of authorities and deportation. The cycle of fear, poverty, and a lack of power compounded as tenants were hesitant to report problems, which reinforced the power of the landlord over the tenant and did nothing to improve living conditions. Recognising the role of landlords in creating substandard housing conditions is important as they represent a group that can be targeted for interventions. 相似文献
104.
105.
碳中和愿景下电力部门低碳转型路径研究 总被引:1,自引:0,他引:1
碳中和愿景一方面加速了全社会电气化发展,致使电力需求持续增加,另一方面对尽早实现零碳电力提出要求,电力部门低碳转型进程更加紧迫而复杂。本文首先定性分析碳中和背景下电力部门的总体转型思路和技术不确定性影响,其次采用电力部门与终端部门耦合的C~3IAM/NET模型对电力需求进行预测,同时根据关键低碳技术发展的保守预期和积极预期设计多种情景,以开展电力低碳转型路径优化和成本效益研究。结果显示,发电碳排放量峰值可能出现在40亿~42亿吨,在2049—2060年有望实现零碳电力,电力部门低碳转型速度和效果因技术不确定性而存在明显差异。2021—2060年电力低碳转型累计投入为171万亿~180万亿元,CCS技术累计减排贡献超过250亿吨,可再生能源电力占比需达到68%以上,风电和光电将成为主要电力。 相似文献
106.
《Journal of environmental science and health. Part. B》2013,48(4):589-601
Abstract Sorption kinetics of atrazine and diuron was evaluated in soil samples from a typical landscape in Paraná. Samples were collected (0–20 cm) in a no-tillage area from Mamborê, PR, which has been cultivated under a crop rotation for the last six years. Six sampling points of the slope were selected to represent a wide range of soil chemical and physical properties found in this area. Radiolabeled tracers (14C-atrazine and 14C-diuron) were used and the radioactivity was detected by liquid scintillation counting (LSC). Sorption was accomplished for increasing equilibration periods (0.5, 1.5, 3, 6, 12, 24, and 48 h). Kinetics data fitted adequately well to Elovich equation, providing evidences that soil reaction occurs in two distinct stages: a fast, initial one followed by a slower one. During the fast phase, 34–42 and 71–79% of total atrazine and diuron applied were sorbed to soil samples. No important differences were found among combinations of soil and herbicide sorption during the slow phase. The unrealistic conditions under batch experiments should be overestimating sorption in the fast phase and underestimating diffusion in the slow phase. Sorption of both herbicides was positively correlated to organic carbon and clay contents of soils, but atrazine was much less sorbed than diuron, showing its higher potential to contaminate groundwater, specially in sandy, low organic carbon soils. 相似文献
107.
Borage, white mustard and phacelia, green manure plants currently used in agriculture to improve soil properties were cultivated for 10 wk on various polluted soils with metal(loid) concentrations representative of urban brownfields or polluted kitchen gardens. Metal(loid) bioavailability and ecotoxicity were measured in relation to soil characteristics before and after treatment. All the plants efficiently grow on the various polluted soils. But borage and mustard only are able to modify the soil characteristics and metal(loid) impact: soil respiration increased while ecotoxicity, bioaccessible lead and total metal(loid) quantities in soils can be decreased respectively by phytostabilization and phytoextraction mechanisms. These two plants could therefore be used for urban polluted soil refunctionalization. However, plant efficiency to improve soil quality strongly depends on soil characteristics. 相似文献
108.
Ji-Feng Yang Shi-Biao Zhou An-Guo Xiao Wen-Jun Li Guang-Guo Ying 《Journal of environmental science and health. Part. B》2013,48(12):909-916
This paper investigated sulfadiazine oxidation by the Fenton process under various reaction conditions. The reaction conditions tested in the experiments included the initial pH value of reaction solutions, and the dosages of ferrous ions and hydrogen peroxide. Under the reaction conditions with pH 3, 0.25 mM of ferrous ion and 2 mM of hydrogen peroxide, a removal efficiency of nearly 100% was achieved for sulfadiazine. A series of intermediate products including 4-OH-sulfadiazine/or 5-OH-sulfadiazine, 2-aminopyrimidine, sulfanilamide, formic acid, and oxalic acid were identified. Based on these products, the possible oxidation pathway of sulfadiazine by Fenton's reagent was proposed. The toxicity evaluation of reaction solutions showed increased antimicrobial effects following the Fenton oxidation process. The results from this study suggest that the Fenton oxidation process could remove sulfadiazine, but also increase solution toxicity due to the presence of more toxic products. 相似文献
109.
Mark Radosevich Samuel J. Traina Olli H. Tuovinen 《Journal of environmental science and health. Part. B》2013,48(4):457-494
Abstract An atrazine‐degrading bacterial isolate (M91–3) was able to utilize simazine and cyanazine as N sources for glucose‐dependent growth. The degradation of these three 5‐triazine herbicides was also investigated in binary and ternary mixtures. The organism used atrazine and simazine indiscriminately, whereas cyanazine degradation was slow and delayed until the depletion of the two other herbicides. There was no apparent effect of other commonly used herbicides on the rate of atrazine degradation by M91–3. 相似文献
110.
纳氏试剂光度法测定水体中氨氮常见问题与解决办法 总被引:2,自引:0,他引:2
针对在实际工作中用纳氏试剂光度法测定水体中氨氮存在的一些问题,在参考相关研究资料的基础上,并根据工作经验,对纳氏试剂光度法测定水体中氨氮常见问题进行了探讨与总结,以期更好的指导实际工作。 相似文献