Aluminum interaction with human brain tau protein phosphorylation by various Kinases

Abstract

Phosphorylation is an indispensable process for energy and signal transduction in biological systems. AlCl₃ at 10 nM to 10 uM range activated in‐vitro [γ‐³²P)ATP phosphorylation of the brain (tau) T protein in both normal human or E.coli expressed T forms; in the presence of the kinases P34, PKP, and PKC. However, higher concentrations of ALCl₃ inhibited the T phosphorylation with P34, PKP, and PKC to a maximum at 1 mM level. AlCl₃ at 100 uM to 500 uM range induced non‐enzymatic phosphorylation of T with γ‐ATP, γ‐GTP, and α‐GTP. AlCl₃ activated histone phosphorylation by P34 in a similar pattern. The hyperphosphorylation of T by Al³⁺ was accompanied by molecular shift and mobility retardation in SDS‐PAGE. This may demonstrate the mechanism of the longterm neurological effect of Al³⁺ in human brain leading to the formation of the neurofibrillary tangles related to Alzeheimer's disease.     

The resource curse

Countries that possess rich mineral deposits, it is widely assumed, are fortunate. Such deposits are assets, part of a country's natural capital. Mining is the key that converts dormant mineral wealth into schools, homes, ports, and other forms of capital that directly contribute to economic development. Over the past two decades, however, a more negative view of mining has emerged that questions the positive relationship between mineral extraction and economic development. The impetus for the alternative view came from empirical studies suggesting that countries where mining is important have not grown as rapidly as other countries. More recent studies have explored the possible reasons behind the disappointing performance of many mineral producing countries. While the central point of contention between the conventional and alternative views — namely, whether or not mining usually promotes economic development — remains unresolved, there is widespread agreement that rich mineral deposits provide developing countries with opportunities, which in some instances have been used wisely to promote development, and in other instances have been misused, hurting development. The consensus on this issue is important, for it means that one uniform policy toward all mining in the developing world is not desirable, despite the recent suggestions by some to the contrary. The appropriate public policy question is not should we or should we not promote mining in the developing countries, but rather where should we encourage it and how can we ensure that it contributes as much as possible to economic development and poverty alleviation.     

职业病危害及经济损失

我国工业职业病危害严重，造成的经济损失巨大，约占年国民经济总产值的２．５％以上，加强对职业病危害的预防、控制，以减少损失十分必要。为保证我国经济建设的顺利进行，必须完善立法，用经济手段强化对职业病的预防、监控和管理。     

Ethical obligations of veterinarians and animal scientists in animal agriculture

It is patent that society is evolving an ethic for the treatment of animals which goes well beyond the standard prohibitions against cruelty. This new ethic for animals takes the consensus ethic for the treatment of humans in society and extends it,mutatis mutandis, to the treatment of animals. Though this ethic has been applied first to research animals, its extension to agricultural animals is inevitable, and has already begun. This article explores the extent to which veterinary medicine and animal science, the major scientific fields relevant to animal agriculture, can accommodate the emerging ethic.     

An integrated modelling approach to assess the risk of wind-borne spread of foot-and-mouth disease virus from infected premises

Foot-and-mouth disease (FMD) is a highly contagious disease of livestock that has serious consequences on livestock production and trade. In Australia, preparedness and planning includes the development of decision-support tools that would assist priority setting and resource management in the event of an incursion. In this paper we describe an integrated modelling approach using geographic information system (GIS) technology to assess the risk of wind-borne spread of FMD virus. The approach involves linking an intra-farm virus production model, a wind transport and dispersal model, and an exposure-risk model to identify and rank farms at risk of wind-borne infection of FMD. This will assist authorities by enabling resources for activities like surveillance and vaccination to be allocated on the basis of risk.     

镉对大鼠肾皮质结合反应的影响

通过体内和体外试验分别研究了镉对肾皮质微粒体谷胱甘肽转移酶(GST)及游离肾近曲小管细胞中葡萄糖醛酸(GA)结合反应的影响.结果表明:(1)体外试验中,在10~(-7)—10~(-3)mol/L浓度范围内,镉可抑制肾皮质微粒休GST活力;(2)体内腹腔注射CdCl_2(2.4mg/kg,连续3天)后,大鼠肾皮质GST活力无明显改变;(3)按同样方式腹腔注射CdCl_2后,可降低游离肾近曲小管细胞中GA和7-羟基香豆素(7-HC)的结合反应;(4)体外试验中,低浓度镉(10~(-7)mol/L)可使肾皮质细胞中GA和7-HC的结合反应增强,而在10~(-6)—10~(-2)mol/L浓度范围内,镉可降低GA和7-HC的结合反应.     

虾塘残饵腐解对养殖环境影响的研究Ⅱ.虾塘底层残饵腐解对沉积物环境的影响

通过室内模拟实验，研究了虾塘过量残饵的分解过程、池底硫化物的生成原理、沉积物中硫化物的积累与扩散过程和还原条件下虾病发生的可能性。结果显示，在３个月的实验时间内，硫化物可渗透沉积物５ｃｍ深度。静止５ｄ即可耗尽池底溶解氧。在虾饵腐解还原环境中，异养细菌总数达２０３×１０６个／ｇ，弧菌数达６８０×１０４个／ｇ，已达到发生红腿病程度     

基于神经网络的尘肺病预测模型研究

针对尘肺病对人体的危害这一现实,本文通过建立神经元网络模型,开发了神经元网络预测系统,利用预测模块对获得的尘肺病发病数据进行了学习并以此形成了稳定的预测模式,以某矿尘肺病发病情况为例进行了评价;结果表明神经元网络模型克服了传统预测模型须建立函数的难题,且预测精度较度,具有重要理论与实际应用价值.