Prenatal diagnosis of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency by steroid analysis in the amniotic fluid of mid-pregnancy: Comparison with HLA typing in 17 pregnancies at risk for CAH

Amniotic fluid (AF) levels of 17-hydroxyprogesterone (17OHP) and testosterone (T) were determined at 16–17 weeks in 17 pregnancies at risk for CAH and results compared to 75 normal controls. The fetus was predicted to be unaffected in 12 cases on the findings of normal AF levels of both 17OHP and T and the latter allowed a correct prediction of fetal sex in all instances. HLA typing confirmed normality in 12 cases revealing 5 carriers, 5 homozygous normal and 2 indeterminate. Steroid levels of the 2 groups were similar. Three fetuses were predicted to be CAH affected on unambiguously high levels of 17OHP and T (in female only). HLA typing was in agreement, and the diagnosis was confirmed in 2 abortuses and a female newborn by physical and hormonal studies. In the last 2 cases AF levels of OHP and T were normal but HLA (A/B/C) genotypes were identical to the CAH affected siblings. Normal physical and hormonal findings in the 2 aborted fetuses would exclude the possibility of an in utero virilizing form of CAH. The discrepancy could be explained on the basis that the fetuses had an allelic form of 21-hydroxylase deficiency or on the basis of recombination (not fully tested). It is concluded that a fully informative prenatal diagnosis of CAH should not rely entirely on HLA typing but on hormonal studies.     

城市污水高效低耗生物脱氮工艺研究

采用活性污泥与生物膜法相结合工艺处理城市生活污水，可以高效去除污水中的有机物和NH4^ -N。研究结果表明：水力停留时间为7．5h、回流比为1．5、无外加碳源时，COD的去除率大于90％，NH4^ -N的去除率大于99％；平均出水COD小于40mg／L，NH4^ -N小于1mg／L，TN的去除率60％左右；反硝化过程的适宜C／N为4～5。     

小诺霉素发酵废水好氧生物处理试验研究

对具有强抑制性污染物的抗生素小诺霉素发酵废水，选择活性污泥、粉末活性炭（ＰＡＣＴ）、纯氧曝气等３种好氧生物处理法进行了比较试验。根据实验结果，小诺霉素发酵废水的生物降解呈抑制动力学，采用Ｍａｒｑｕａｒｔ方法对动力学模式进行参数估计。ＰＡＣＴ能够有效地降低降解过程中微生物受到的抑制作用，从而明显地改善了生物处理过程动力学。     

Amniotic fluid alpha-fetoprotein levels and prenatal diagnosis of autosomal trisomies

Pregnancies with fetal trisomy 21 have been associated with low amniotic fluid alpha-fetoprotein levels (AFAFP). This observation led to the suggestion that low AFAFP levels be used as a criterion for completion of a chromosomal analysis in patients who are not otherwise at increased risk for a fetal chromosome abnormality and in whom karyotyping might not have been completed for economic reasons. In order to assess the usefulness of such criteria, we reviewed the AFAFP levels of 90 cases of fetal trisomy 21, 23 cases of trisomy 18, and 10 cases of trisomy 13. These were compared with 2400 control samples with normal chromosome constitution. AFAFP levels were generally lower in pregnancies with trisomy 21, showing a median value of 0·72 MoM. However, 40 per cent of the trisomy 21 samples had AFAFP values greater than 0·8 MoM and 20 per cent were over 1·0 MoM. These data imply that over 50 per cent of Down syndrome cases might have been missed using a cut-off level of 0·70 MoM for completion of chromosome analysis. Using a higher cut-off level will leave only a small percentage of samples unkaryotyped. The distribution of AFP levels in trisomy 13 and 18 is no different from controls; we therefore believe that fetal karyotyping should be completed in every amniotic fluid sample obtained.     

温泉宾馆室内PM_(10),PM_(2.5),CO_2和~(222)Rn的研究

对广东省 4座温泉宾馆室内外氡(222Rn)浓度和温泉水氡浓度进行研究,同时利用便携式探测器对室内外 PM10,PM2.5,CO2和CO 等污染物暴露水平进行直接测定.结果表明,温泉宾馆室内使用温泉水时氡浓度明显高于广东省室内平均氡浓度.除 CO 外,室内 PM10,PM2.5 和CO2 浓度都较高,其中 PM10 和 CO2 的超标率分别达到 67%和 89%.说明温泉宾馆室内不仅存在一般性污染物,而且存在高浓度的 Rn. 222     

金堆城超大型钼矿床水-岩δD-δ~(18)O同位素交换体系理论模型及成矿流体来源

基于水-岩δD-δ18O同位素交换体系理论模型的建立和计算，对金堆城超大型斑岩钼矿四个不同成矿期中成矿流体的演化和来源进行了研究，发现在成矿前期和早期，成矿流体为岩浆水与围岩在较低水／岩比值（0．1W／R＞0．001）和中、高温（t=250～500℃）条件下反应后的残余流体，而主成矿期和成矿晚期的成矿流作为大气降水在相对较高水／岩比值（0．5＞W／R0．1）和中、低温（t＝150～310℃）条件下与围岩反应后的残留流体。大气降水在金堆城钼矿成矿过程中起了重要作用。在主成矿期水／岩比值达到最高。     

活性炭厌氧流化床处理毒性有机废水存在的问题与对策

活性炭厌氧流不处理毒性有机废水存在问题，对含有活性炭能吸附而生物难降解成份的废水，通过定期替换少量活性炭、能维持工艺的稳定运行。     

TiO_2光催化剂固定化技术及光催化反应器研究

从TiO2光催化剂的固定化技术和分类以及光催化反应器的研究进展状况方面进行了综述,指出存在的问题并提出改进方法。     

Monitoring and economic factors affecting the economic viability of afforestation for carbon sequestration projects

The Kyoto Protocol is the first step towards achieving the objectives of the United Nations Framework Convention on Climate Change and aims among others to promote ‘the protection and enhancement of carbon sinks and reservoirs’. To encourage afforestation for carbon sequestration a project must be economically viable. This study uses a model to analyse the impact on project viability of a range of carbon monitoring options, international carbon credit value and discount rate, applied to a Pinus radiata afforestation project in New Zealand. Monitoring carbon in conjunction with conventional forest inventory shows the highest return. Long-term average carbon accounting has lower accounting costs, compared to annual and 5 yearly accounting, as monitoring is only required every 5–10 years until the long-term average is attained. In this study we conclude that monitoring soil carbon stocks is not economically feasible using any of the accounting methods, when carbon is valued at US$ 10/t. This conclusion may be relevant to forest carbon sequestration projects elsewhere in the world and suggests care is needed in selecting the appropriate carbon monitoring options to avoid the risk that costs could be higher than any monetary benefits from terrestrial carbon sequestration. This would remove any commercial incentive to afforest for carbon sequestration reasons and severely limit the use of forest sinks as part of any package of measures addressing the ultimate objective of the UNFCCC.     

Amniotic fluid fibrinolytic system in fetal neural tube defects

Second trimester amniotic fluid fibrinolytic system was examined in normal pregnancies and those complicated by anencephaly, spina bifida and fetal chromosome abnormalities. No significant difference was demonstrated between the fibrinolytic systems from normal pregnancies and those complicated by fetal chromosome abnormalities. In pregnancies complicated with anencephaly and spina bifida no significant difference was demonstrated for alpha-1-antitrypsin, alpha-1-antichymotrypsin and urokinase. Plasminogen was significantly lower (p < 0.02) and plasmin significantly higher (p < 0.001) than levels from normal amniotic fluid. Alpha-2-macroglobulin, fibrinogen, FDP-D and FDP-E were detected only in pregnancies complicated with anencephaly and spina bifida.