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EffectsofCa ̄(2+)ionsantagonistictoAl ̄(3+)ionspoisoninginrootgrowth,celldivisionandnucleolusinroottipcellsofAlliumcepaLiuDongh... 相似文献
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J. M. M. van Lith MD J. R. Beekhuis A. J. van Loon A. Mantingh B. T. H. M. de Wolf A. S. P. M. Breed 《黑龙江环境通报》1991,11(8):625-628
In order to gain more insight into the association between alpha-fetoprotein (AFP) and fetal chromosomal disorders, especially Down's syndrome, we measured AFP in fetal serum, amniotic fluid, and maternal serum at cordocentesis. We compared the concentration and gradient of AFP in these three compartments. Our data confirm earlier findings on second-trimester fetal serum AFP concentration. The results indicate that low maternal serum AFP in pregnancies with fetal chromosomal disorders could result from an impaired fetal kidney function as well as from impaired membrane or placental passage of AFP, rather than from reduced fetal AFP production. 相似文献
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The effects of different concentrations of Zn2+ion on root growth,cell division,and nucleoli of Allium cepa were studied. The test Zn2+ ion concentration was made up from zinc sulphate (ZnSO4. 7H2O) ranging from 10-7 to 10-2 mol/L. The solutions were prepared in tap water (pH =6. 5).The results indicated that Zn2+ could obviously inhibit root growth at concentrations from 10-4)to 10-2 mol/L.Roots treated with zinc sulphate showed the presence of c-mitosis, anaphase bridges,including sticky and fluidized bridges (at 10-3 to 10-2 mol/L) , chromosome stickiness, irregularly shaped nuclei, broken nuclei and micronuclei. A toxicity effect was also observed on the nucleoli using silver staining technique after 48h of treatment with 10-4to 10-2 mol/L Zn2+, e. g,the nucleolar particulate material scattered around the nucleoli in the nucleus of root tip cells. 相似文献
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农药乙蒜素和细菌溴腈对蚕豆根尖细胞的致畸效应 总被引:3,自引:0,他引:3
利用蚕豆根尖微核技术研究农药乙蒜素和细菌溴腈对蚕豆根尖细胞的遗传损伤,测定蚕豆根尖细胞的微核率、有丝分裂指数和染色体畸变率.结果表明:2种农药均能诱发较高频率的微核率、有丝分裂指数和染色体畸变率.在乙蒜素质量浓度为0.032~0.160 g·L-1范围内,微核率随浓度升高而升高,呈一定的剂量-效应关系(r=0.881 9,P≤0.01);而在细菌溴腈质量浓度为0.625~2.5 g·L-1范围内,微核率则呈先上升后下降的趋势. 相似文献
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本文对化学品登记所要求的部分健康效应数据——皮肤致敏、重复经口染毒、致变做了解释.涉及到的测试参数包括:皮肤致敏、重复(14/28天)经口啮动物毒性、基因突变、染色体畸变和DMA效应. 相似文献
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Deepak Kumar A. Rajeshwari Pradeep Singh Jadon Gouri Chaudhuri Anita Mukherjee Natarajan Chandrasekaran Amitava Mukherjee 《环境科学学报(英文版)》2015,38(12):150-157
The current study evaluates the cytogenetic effects of chromium (III) oxide nanoparticles on the root cells of Allium cepa. The root tip cells of A. cepa were treated with the aqueous dispersions of Cr2O3 nanoparticles (NPs) at five different concentrations (0.01, 0.1, 1, 10, and 100 μg/mL) for 4 hr. The colloidal stability of the nanoparticle suspensions during the exposure period were ascertained by particle size analyses. After 4 hr exposure to Cr2O3 NPs, a significant decrease in mitotic index (MI) from 35.56% (Control) to 35.26% (0.01 μg/mL), 34.64% (0.1 μg/mL), 32.73% (1 μg/mL), 29.6% (10 μg/mL) and 20.92% (100 μg/mL) was noted. The optical, fluorescence and confocal laser scanning microscopic analyses demonstrated specific chromosomal aberrations such as—chromosome stickiness, chromosome breaks, laggard chromosome, clumped chromosome, multipolar phases, nuclear notch, and nuclear bud at different exposure concentrations. The concentration-dependent internalization/bio-uptake of Cr2O3 NPs may have contributed to the enhanced production of anti oxidant enzyme, superoxide dismutase to counteract the oxidative stress, which in turn resulted in observed chromosomal aberrations and cytogenetic effects. These results suggest that A. cepa root tip assay can be successfully applied for evaluating environmental risk of Cr2O3 NPs over a wide range of concentrations. 相似文献
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