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排序方式: 共有190条查询结果,搜索用时 125 毫秒
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J. M. M. van Lith MD J. R. Beekhuis A. J. van Loon A. Mantingh B. T. H. M. de Wolf A. S. P. M. Breed 《黑龙江环境通报》1991,11(8):625-628
In order to gain more insight into the association between alpha-fetoprotein (AFP) and fetal chromosomal disorders, especially Down's syndrome, we measured AFP in fetal serum, amniotic fluid, and maternal serum at cordocentesis. We compared the concentration and gradient of AFP in these three compartments. Our data confirm earlier findings on second-trimester fetal serum AFP concentration. The results indicate that low maternal serum AFP in pregnancies with fetal chromosomal disorders could result from an impaired fetal kidney function as well as from impaired membrane or placental passage of AFP, rather than from reduced fetal AFP production. 相似文献
34.
The effect of repeat testing in maternal serum multiple marker screening for Down's syndrome was estimated using samples stored in an antenatal serum bank. Human chorionic gonadotropin (hCG) and unconjugated oestriol (uE3) levels were determined in 142 pairs of routinely collected samples which had already been tested for alpha-fetoprotein (AFP). For each marker, about two-thirds of the pairs of values were within 20 per cent of each other and most were within 40 per cent. A multivariate Gaussian model was used to estimate the detection and false-positive rates for different repeat testing policies. A policy of repeat testing those with a high risk of a Down's syndrome term pregnancy given age and marker levels would reduce the false-positive rate but there would also be a reduction in the detection rate. For example, using all three markers and a 1 in 250 cut-off risk, the estimated false-positive rate would fall from 5·3 to 3·8 per cent but the detection rate would decrease from 58 to 55 per cent. A policy of repeating those with either high or borderline risks would produce a modest improvement in screening efficiency. Repeating the 11 per cent with a risk exceeding 1 in 500 yields an estimated false-positive rate of 5·0 per cent and a detection rate of 60 per cent. A policy of selective repeat testing is not recommended as it would not substantially improve screening efficiency. Nonetheless, if a repeat test has been performed, the parameters given in this paper will enable an unbiased estimate of the Down's syndrome risk to be calculated for individual women. 相似文献
35.
Françoise Serville Paule Benit Pascale Saugier Mireille Vibert Ghislaine Royer Anna Pelet Michèle Chery Arnold Munnich Stanislas Lyonnet 《黑龙江环境通报》1993,13(6):435-439
X-linked hydrocephalus-stenosis of the aqueduct of Sylvius sequence (H-SAS, MIM number 307 000) is a rare genetic disorder characterized by hydrocephalus, macrocephaly, adducted thumbs, spasticity, mental retardation, and cerebral malformations. This regularly lethal condition is usually diagnosed at birth or prenatally by ultrasound, but hydrocephalus may be moderate or even undetectable on fetal ultrasound examination. Moreover, since heterozygous women are asymptomatic, carrier detection is at present impossible before the birth of an affected son. Therefore, mapping the H-SAS locus to distal Xq (Xq28) was of primary importance for genetic counselling and prenatal diagnosis. Here, we report prenatal exclusion of H-SAS with a probability of 97.6 per cent in two male fetuses with a 50 per cent a priori risk of being affected using closely linked Xq28 DNA markers. 相似文献
36.
Thirty-nine deep subsurface soils( 150—180 cm depth) near the outskirts of Beijing were investagated. The concentrations including n-alkanes from C13 to C36, pristane and phytane were in the range of 0.60 to 170.10μg/g, with a median value of 4.26. Carbon preference index values for n-alkanes ranged from 1.08 to 2.98, with a median value of 1.48. The percentage contribution of “wax” nalkanes was in the range of 6.03%--46.22%. A predominance of odd/even carbon n-alkanes and unresolved complex mixtures with different shapes and ranges were frequently observed. Factor analysis reduced the data set into three principal components and confirming contributions from low ( 19.58% ), medium ( 20.49% ) molecular weight species and long-chain n-alkanes (43.41% ), respectively.Molecular biomarkers such as pristane, phytane, hopanes and steranes were detected. Based on the principal component analysis, the concentration profiles and molecular markers, it was found that the aliphatic hydrocarbons were from both biogenic and anthropogenic sources. 相似文献
37.
G. Loudianos A. L. Figus A. Loi A. Angius V. Dessì M. Deiana S. De Virgiliis G. Monni A. Cao M. Pirastu M.D. 《黑龙江环境通报》1994,14(10):999-1002
This paper describes a case of prenatal diagnosis for Wilson disease (WD) carried out in an at-risk couple of Sardinian descent, following non-directive genetic counselling. Diagnosis was obtained by using eight microsatellites located within or flanking the WD locus, six of which were 100 per cent and two 50 per cent informative. The use of several markers may limit the occurrence of misdiagnosis resulting from recombination or instability of repeats. 相似文献
38.
Alternative male mating tactics in a cichlid, Pelvicachromis pulcher: a comparison of reproductive effort and success 总被引:2,自引:0,他引:2
Pelvicachromis pulcher is a small African cichlid which breeds in holes. Males may either reproduce monogamously (pair males), polygynously (harem
males), or be tolerated as helpers in a harem territory (satellite males). These helpers share in defence of the territory
against conspecifics, heterospecific competitors and predators. There are two male colour morphs that are fixed for life and
are apparently genetically determined. These differ in their potential mating strategy. Red morph males may become harem owners,
while yellow morph males may become satellite males, and males of both morphs may alternatively pair up monogamously. We compared
the reproductive effort and success of these three male reproductive strategies. Effort was measured as attack rates, time
expenditure and the risk of being injured or killed when attacking competitors or predators of three sympatric fish species.
Reproductive success was measured by observing how many eggs were fertilized by each male when this was possible, and by using
genetic markers. The number of fry surviving to independence of parental care was used as a criterion of success. The reproductive
success of harem males was 3.3 times higher than that of pair males and 7 times higher than that of the average satellite
male. Dominant satellite males, however, were as successful as monogamous pair males, using the measure of fertilized eggs.
To our knowledge, this has not been found previously in any fish species. Both harem and pair males had lower parental defence
costs per sired offspring, however, than males using the alternative satellite tactic. Defence effort was significantly related
to the risk of injury.
Received: 17 January 1996 / Accepted after revision: 9 June 1997 相似文献
39.
本文对化学品登记所要求的部分健康效应数据——皮肤致敏、重复经口染毒、致变做了解释.涉及到的测试参数包括:皮肤致敏、重复(14/28天)经口啮动物毒性、基因突变、染色体畸变和DMA效应. 相似文献
40.
同源四倍体与二倍体水稻Wx基因位点的遗传差异 总被引:2,自引:3,他引:2
测定了中国科学院成都生物所培育出的14种同源四倍体水稻及8种大面积推广的二倍体水稻的直链淀粉含量,并利用微卫星标记484/485,Wxup2/485及PCR—AceⅠ分子标记对同源四倍体及二倍体水稻进行扩增.发现直链淀粉含量发生变化的部分同源四倍体水稻队基因位点发生变异,表明微卫星标记与同源四倍体水稻直链淀粉含量之间存在相关性,并初步探讨了同源四倍体水稻Wx基因位点遗传变异的原因.图2表1参13 相似文献