Fish consumption in pregnancy, cord blood mercury level and cognitive and psychomotor development of infants followed over the first three years of life: Krakow epidemiologic study

BACKGROUND: Although the maternal fish consumption is supposed to have beneficial effects on development of infants, it may be harmful for child cognitive development since fish is a common source of methylmercury. PURPOSE OF THE STUDY: Purpose of the study was to describe the usual pattern of fish consumption during pregnancy in Poland and explain the variability of prenatal mercury exposure due to fish intake by mothers. The other endpoint of the study was the assessment of the cognitive and psychomotor development of infants related to prenatal mercury exposure over the 3-year follow-up. MATERIAL AND METHODS: The study sample consisted of 374 infants born at 33-42 weeks of gestation between January 2001 and March 2003 to mothers attending ambulatory prenatal clinics in the first and second trimesters of pregnancy. Total mercury level in whole cord blood was measured and the Bayley Scales of Infant Development (BSID-II) was used to assess the mental (MDI) and psychomotor developmental index (PDI) in children at 12, 24 and 36 months of age. RESULTS: Self-reported weekly amount of fish consumption during the first two trimesters of pregnancy correlated positively with umbilical cord mercury concentrations (r(s)=0.22, p<0.0001). The corresponding correlation coefficient for the fish consumption in the third trimester of pregnancy was 0.21, p<0.0001. There was an inverse association between mercury exposure and both MDI (beta regression coeff.=-2.8, p=0.01) and PDI scores (beta coeff.=-2.3, p=0.04) at 12 months of age. Subsequent BSID-II testing at 24 and 36 months did not confirm significant association between exposure and cognitive or psychomotor function. The estimates of association between mercury prenatal exposure and the development of infants, which were based on the longitudinal analysis of all BSID-II measurements done in the follow-up (generalized estimating equations statistical model) showed that the performance deficit observed at 12 months of age was of border significance.     

水库水质监测及分析系统设计研究

水库水质监测及分析系统集控制技术、计算机应用技术、通信技术、地理信息技术和仪表分析技术为一体,可视化展示水库水质动态,并依据水质质量评价规范,分析和评价各监测项目,进行有效的监控预警。系统可根据数学模型对水质进行模拟计算,为水库的管理监督、决策规划、污染防治等工作提供决策支持,同时增强管理部门应对突发性污染事故快速反应能力。     

新型快滤装置处理初降雨径流的研究

本研究探索了人工快滤系统(简称CRI系统)处理初降雨径流污染的可行性。通过室内试验,比选出合适的滤料,对过滤参数进行优化,设计2种快滤模块,并运用于实际工程建设中。结果表明:粒径3～5mm河砂对SS、COD污染的去除效果良好。选取9L/(m2·s)为适宜过滤流量负荷,0.6m为合适滤料高度,模型装置对污水的处理效果良好。     

鄱阳湖湿地植被退化原因分析及其预警

2003年以来,鄱阳湖长期处于低枯水位状态,湖盆植被面积减少600km2;洲滩土壤含水量降低,旱生植物物种入侵,占据高程15m以上洲滩,湿地植被演变成中生性草甸,使物种大幅度增加;湿生和水生植物向湖中心下移,生长空间缩减;对水深、污染物敏感的植物群落的物种、生物量减少,生物多样性退化;对水深适应性强和耐污染的植物迅速扩张。无序采砂、防火烧荒、牲畜放牧加剧了这一局面。在气候变化和人类活动影响下,鄱阳湖湿地植被正在逐步退化。为了遏制这一退化现象,正在建立鄱阳湖健康评价体系与标准,加强植物群落固定断面和针对稀有物种、对水深和污染物敏感物种、危害湖泊健康物种进行专项监测,针对发现的问题,用遥感影像辨识、实地勘测研究分析全湖变化状况,判断其危害程度,提出防治对策,向相关部门和地区提出预警建议。     

数据缺失条件下基于MLP神经网络的水华风险预警方法研究

针对水华风险预警过程中相关监测指标数据缺失的问题,借鉴多元统计和随机分析构建了一种缺失数据插补方法,用于弥补现场调查数据的不足.基于主成分分析,对水华相关影响指标进行降维,确定水体水华风险预警模型的输入层变量.同时,采用多层感知器(MLP)人工神经网络模型对水华表征指标叶绿素a的浓度进行预测,并引入风险概率的概念,提出了水华风险概率计算公式,完善了水华预警的风险表达.最后以三峡库区典型支流大宁河为案例的研究证明了上述方法的可操作性.研究结果显示,插补数据条件下和未插补数据条件下的大宁河水华风险预警模型决定系数分别为0.9711和0.7769,前者的模型准确性更高,叶绿素a浓度预测效果更好;预测时段内大宁河11 d为水华蓝色预警(无警)级别,水华发生的风险概率为1.99%~18.61%;1 d达到水华橙色预警(中警)级别,水华发生概率为90.48%.     

不同季节大气可吸入颗粒物(PM_(10))诱导小鼠原代培养神经元炎性及其级联损伤效应

为了探讨不同季节可吸入颗粒物(PM10)对神经元的损伤效应,本研究通过建立小鼠大脑皮层原代神经元体外染毒模型,考察了不同季节PM10对炎性因子诱导型一氧化氮合酶(iNOS)、环氧化酶-2(COX-2)和黏附分子(ICAM-1)表达水平的影响,并探讨了与之耦联的磷酸化Ca2+/钙调蛋白依赖性蛋白激酶Ⅱα(p-Ca MKⅡα)、环磷腺苷效应元件结合蛋白(p-CREB)及即早基因(c-jun、c-fos)的表达情况.结果表明,PM10暴露刺激神经元炎性细胞因子释放增加,显著上调p-Ca MKⅡα和p-CREB的水平,并刺激即早基因的高表达,且以冬季PM10的效应最为明显.由此提示,PM10暴露可能通过炎症反应机制激活Ca2+-Ca MK-CREB通路,进而刺激即早基因表达引发神经毒性作用,而冬季PM10中多环芳烃类物质负荷可能是造成效应季节性差异的主要原因.     

高校债务风险预警模型构建及配套策略研究

高校银行贷款的风险防范，是一个关系到学校生存与发展的大问题，许多的防范策略都各有一定的实用价值．但传统的预警模型实用性不佳，主要是一些细节存在着理论缺陷，效果不显著．根据高校债务风险的基本状况，排出其风险预警体系的构成因素，对一般的风险预警模型，做出适度调整，引入债务负担率和债务依存度的概念，使预警模型更符合高校实际，能够很好地预警债务风险，以利防范．图2，参6．