猪血酶解工艺研究

用研制成功的复合酶和酶解工艺技术，将难于消化的猪血蛋白质水解成１８种氨基酸和部分低肽的固体产品，富含铁、铜、锰、锌等微量元素，血蛋白消化吸收率从２０％左右提高到９５％以上，蛋白质水解率９９．５％，产品中氨基酸总量８５．５％，其中８种必需氨基酸含量３６．１％，产品微生物和理化指标均符合国家食品卫生标准，生产工艺先进合理、生产成本低、对环境无污染．     

微孔草的特征及利用价值研究

微孔草是青藏高原特有植物种,种子油中富含γ-亚麻酸、亚油酸,不饱和脂肪酸的含量达85%以上;种子中含有18种氨基酸,其中人体必需氨基酸的含量达39.74%;矿物质营养元素极其丰富;饼渣中的粗蛋白含量达23.96%。它具有药用、食用和饲用等多种用途。因而,多层次开发利用微孔草资源是提高草地生态系统生产能力的重要措施。     

Driving under the influence of alcohol and drugs in the eastern part of Denmark in 2015 and 2016: Abuse patterns and trends

Objectives: The objective of this study was to examine the frequency of psychoactive drugs and alcohol in drivers under suspicion of driving under the influence of drugs and alcohol in 2015 and 2016 in the eastern part of Denmark. The trends in the number of traffic cases sent for drug analysis since 2000 and alcohol analysis since 2011 are also discussed.

Methods: Blood samples from drivers suspected of being under the influence of alcohol and/or medication and/or illicit drugs in 2015 and 2016 were investigated as requested by the police. The blood samples were screened for alcohol and/or tetrahydrocannabinol (THC) alone, for other drugs (covering all drugs, except THC, listed in the Danish list of narcotic drugs), or for THC and other drugs. Age and gender were also recorded. The number of drug traffic cases since 2000 and the number of alcohol cases since 2011 were extracted from our Laboratory Information Management System (LIMS).

Results: In total, 11,493 traffic cases were investigated. Alcohol and/or drugs exceeded the legal limit in 9,657 (84%) cases. Men constituted 95% of the drivers investigated for drugs and 88% of the alcohol cases. The drivers investigated for drugs consisted primarily of young men, whereas drivers investigated for alcohol were older.

The frequency was higher for positive alcohol cases above the legal limit (87%) than for drug cases (76%) above the fixed concentration limit. THC (67–69%) was the most frequently detected drug above the legal limit, followed by cocaine (27–28.5%), amphetamine (17%), and clonazepam (6–7%) in both years. Morphine (5.4%), included among the 5 most frequent drugs in 2015, was replaced by methadone (4.6%) in 2016. Few new psychoactive drugs (NPS) were detected.

The number of traffic cases sent for drug analysis has increased more than 30-fold since 2000–2006, and the number of traffic cases submitted in 2016 for drug analysis was higher than the number for alcohol analysis; the latter has decreased since 2011.

Conclusion: Overall, alcohol was the most frequent compound detected above the legal limit in both years, followed by the well-known illicit drugs THC, cocaine, and amphetamine. NPS were seldom seen. One consequence of the increased focus on drugs in traffic has been an immense increase in drug traffic cases sent for analysis since 2006 in the eastern part of Denmark. Although this survey revealed only minimal changes compared to earlier investigations, surveys like this are invaluable for monitoring abuse patterns and trends in drugged and drunken driving.     

Simultaneous effect of shift work on blood pressure and lipid profile: a path analysis

The aim of this study was to assess the direct and indirect effects of shift work (SW) on the systolic blood pressure (SBP) and lipid profile of male workers. For this purpose, a cross-sectional study was conducted involving 6539 male workers of Esfahan Mobarakeh Steel Company. From all of the participants, 3065 (46.8%) were day workers and the remainder were shift workers. The results of path analysis revealed that the most effective variables on SBP were body mass index, fasting blood sugar, triglycerides and SW with a total effect of 0.241, 0.095, 0.064 and 0.056, respectively.     

汽车尾气对人精子运动能力影响探讨

采用［日］岛津AA－670型原子吸收分光光度计,四唑氮蓝（Nitro－BT）染色法,及图象分析仪（MIAS－300）分析了交通警察和男性师生两人群精液的精子运动能力参数和血铅水平。结果显示：与对照组比较,交警组精子活动能力降低（P＜0.05）,精子琥珀酸脱氢酶（SDH）活性明显抑制（P＜0.001）。而且SDH活性与血铅水平呈负相关。认为交警精子活动能力下降可能和铅干扰精子线粒体能量代谢有关。     

取代苯酚对人体外周血淋巴细胞的遗传毒性及定量结构关系

应用人体外周血淋巴细胞微核试验测定了29种取代苯酚类化合物的遗传毒性(72h-lgMN20),并对此类化合物的遗传毒性大小进行了分析比较,同时构建了遗传毒性与分子结构参数之间的QSAR 模型.结果表明,29种取代苯酚类化合物都显著地导致了微核的产生,具有明显的遗传毒性;遗传毒性大小与取代官能团及官能团位置存在一定的规律;遗传毒性的大小与分子结构参数溶剂连接性指数(X2SOL)、自由基信息参数(ICR)、零阶平均分子连接性指数(X0A)及修正指数(LOP)之间存在良好的结构-活性相关关系,所建模型的相关系数r2= 0.816,可以用于定量评估其它取代苯酚类化合物的遗传毒性.