Photophysical and photochemical properties of the pharmaceutical compound salbutamol in aqueous solutions

Salbutamol is a potent β₂-adrenergic receptor agonist widely used in the treatment of bronchial asthma and chronic obstructive pulmonary disease. An increasing number of studies have detected salbutamol in natural water systems worldwide. Studies have shown that sunlight degrades salbutamol resulting in the formation of products; some showing higher toxicity to bacteria Vibrio fischeri than the parent compound. In this contribution, steady-state absorption and emission techniques, high-performance liquid chromatography, and transient absorption spectroscopy are used to investigate the photochemistry of salbutamol in aqueous buffer solutions at controlled pH values. Ground- and excited-state calculations that include solvent effects are performed to guide the interpretation of the experimental results. Salbutamol is sensitive to UVB light absorption in the pH range from 3 to 12, forming products that absorb light at longer wavelengths than the parent compound. Quantum yields of degradation reveal that the deprotonated species is 10-fold more photo-active than the protonated species. In line with this result, the fluorescence quantum yield of the protonated species is more than an order of magnitude higher than that of the deprotonated species. Transient absorption spectroscopy shows that population of the triplet state occurs with a rate constant of 7.1 × 10⁸ s⁻¹ in the protonated species, while a rate constant of 1.7 × 10¹⁰ s⁻¹ is measured for the deprotonated species. While degradation of the deprotonated species is not affected by the presence of molecular oxygen, a twofold increase in the photodegradation yield of the protonated species in air-saturated conditions is observed.     

中国工业化进程与能源矿产供需均衡的研究

工业化与能源需求的均衡关系及解决工业化进程中能源供需失衡的战略途径是中国工业化进程中需要探讨的重大问题.文章运用协整技术,就1990-2008年间中国工业化进程与能源需求协整关系的检验,认为中国工业化与能源需求增长具有长期稳定的均衡关系,能源需求将继续保持增长,能源利用效率也将持续提高.然而工业化进程中重工业化高能耗结构特征与能源低效利用并存的困境以及能源供需矛盾不利于能源供需平衡的平稳发展.我国应适应工业化进程的基本规律,转变能源消费方式;走新型工业化道路,适当限制低附加值产业发展,鼓励产业向离附加值、低能耗、高技术产业转移;在实现能源开发利用技术进步和创新的同时.有效利用国内外能源资源;建立能源应急机制等战略途径来实现工业化进程中能源供需平衡发展.     

粤北地区干旱监测及预警方法研究

从农业生产实际出发,引入能够判断作物受旱程度的毛管破裂含水量、凋萎含水量等土壤含水量指标来确定干旱指标,根据土壤水分平衡理论,建立干旱监测预警模型,利用自动站气象资料和降水趋势预报对干旱情况进行判别和分析,并采用Surfer软件对干旱情况进行直观的图形显示.     

Structuring Decisions for Managing Threatened and Endangered Species in a Changing Climate

The management of endangered species under climate change is a challenging and often controversial task that incorporates input from a variety of different environmental, economic, social, and political interests. Yet many listing and recovery decisions for endangered species unfold on an ad hoc basis without reference to decision‐aiding approaches that can improve the quality of management choices. Unlike many treatments of this issue, which consider endangered species management a science‐based problem, we suggest that a clear decision‐making process is equally necessary. In the face of new threats due to climate change, managers’ choices about endangered species require closely linked analyses and deliberations that identify key objectives and develop measurable attributes, generate and compare management alternatives, estimate expected consequences and key sources of uncertainty, and clarify trade‐offs across different dimensions of value. Several recent cases of endangered species conservation decisions illustrate our proposed decision‐focused approach, including Gulf of Maine Atlantic salmon (Salmo salar) recovery framework development, Cultus Lake sockeye salmon (Oncorhynchus nerka) management, and Upper Columbia River white sturgeon (Acipenser transmontanus) recovery planning. Estructuración de Decisiones para Manejar Especies Amenazadas y en Peligro en un Clima Cambiante     

EFFECTS OF CLIMATIC CHANGE ON THE THORNTHWAITE MOISTURE INDEX1

ABSTRACT: The Thornthwaite moisture index is a useful indicator of the supply of water (precipitation) in an area relative to the demand for water under prevailing climatic conditions (potential evapotranspiration). This study examines the effects of changes in climate (temperature and precipitation) on the Thornthwaite moisture index in the conterminous United States. Estimates of changes in mean annual temperature and precipitation for doubled-atmospheric CO₂ conditions derived from three general circulation models (GCMs) are used to study the response of the moisture index under steady-state doubled-CO₂ conditions. Results indicate that temperature and precipitation changes under doubled-CO₂ conditions generally will cause the Thornthwaite moisture index to decrease, implying a drier climate for most of the United States. The pattern of expected decrease is consistent among the three GCMs, although the amount of decrease depends on which GCM climatic-change scenario is used. Results also suggest that changes in the moisture index are related mainly to changes in the mean annual potential evapotranspiration as a result of changes in the mean annual temperature, rather than to changes in the mean annual precipitation.     

HYDROLOGIC EFFECTS OF CLIMATE CHANGE IN THE DELAWARE RWER BASIN1

ABSTRACT: The Thornthwaite water balance and combinations of temperature and precipitation changes representing climate change were used to estimate changes in seasonal soil-moisture and runoff in the Delaware River basin. Winter warming may cause a greater proportion of precipitation in the northern part of the basin to fall as rain, which may increase winter runoff and decrease spring and summer runoff. Estimates of total annual runoff indicate that a 5 percent increase in precipitation would be needed to counteract runoff decreases resulting from a warming of 2°C; a 15 percent increase for a warming of 4°C. A warming of 2° to 4°C, without precipitation increases, may cause a 9 to 25 percent decrease in runoff. The general circulation model derived changes in annual runoff ranged from ?39 to +9 percent. Results generally agree with those obtained in studies elsewhere. The changes in runoff agree in direction but differ in magnitude. In this humid temperate climate, where precipitation is evenly distributed over the year, decreases in snow accumulation in the northern part of the basin and increases in evapotranspiration throughout the basin could change the timing of runoff and significantly reduce total annual water availability unless precipitation were to increase concurrently.     

ESTIMATING REGIONAL SNOW WATER EQUIVALENT WITH A SIMPLE SIMULATION MODEL1

A simple simulation model designed to monitor snow-packs of the central Sierra Nevada is described. The model estimates average snow water equivalent for rectangular subregions in the area. Static subregion characteristics, daily precipitation and mean and minimum air temperatures measured at three index stations are the only needed input values. A water balance technique simulates daily snowpack changes in each subregion. Reasonable basinwide water equivalent values are produced. The procedure should be useful for estimating snow water distribution in large mountainous watersheds.     

ESTIMATION OF ENERGY REQUIREMENTS OF MORNING DEW EVAPORATION FROM LEAF SURFACES1

ABSTRACT: Evapotranspiration from vegetation is generally computed without consideration for early morning energy loss involved in drying wet leaf surfaces. In humid areas where dew formation is frequent, estimation of energy requirements for evaporating dew should be of interest. In this study, sensible heat flux (H) was computed from wind and temperature profile measurements over the study site. A leaf wetness sensor was used to measure the duration of evaporation from an exposed leaf surface, and net radiation was measured with a radiometer. The energy flux during the period of wet leaf surface evaporation was integrated over time. A cattail lysimeter situated at the site indicated the time when evapotranspiration started after wet leaves were dry. The energy requirements to dry an exposed wet leaf surface was estimated using energy balance methods. The mean value based on 44 days of observations from mid February to early May of 1993 indicates that the energy required to evaporate dew from openly exposed wet leaves was 5 percent of the total daily evapotranspiration of cattails with a coefficient of variation of 0.72. The mean time required to evaporate dew from exposed leaf surfaces from the onset of positive net radiation was 78 minutes. The mean dew evaporation in a morning from an exposed leaf surface was 0.16 mm with a maximum value of 0.41 mm. The energy required to dry wet leaves is a factor that should be considered when modeling evapotranspiration at hourly or shorter time intervals. Also, physical evapotranspiration models need to account for energy requirements for drying dew and rainfall wetted leaves.     

WEST AFRICA: VOLTA DISCHARGE DATA QUALITY ASSESSMENT AND USE1

ABSTRACT: Water resource management in West Africa is often a complicated process due to inadequate resources, climatic extremes, and insufficient hydrological information. Insufficient data hinder sustainable watershed management practices, one of the top priorities in the Volta River Basin. This research properly fills in missing data by modeling the hydrological distribution in the Volta River Basin. On average, discharge gages across the basin are missing 20 percent of their monthly data over 20 years. Two methods were used to supplement missing data: a statistically linear model and a conceptual hydrological model. A linear equation, developed from the regression of precipitation and runoff, was used to evaluate the quality of existing data. The hydrological model separates the system into root and groundwater zones. Measured values were used to calibrate the hydrological model and to validate the statistical model. The quality of existing data was analyzed and organized for usability. Accuracy of the hydrological model was also evaluated for its effectiveness using R² and standard error. It was found that the hydrological model was an improvement from the linear model on a monthly basis; R² values improved by as much as 0.5 and monthly error decreased. Monthly predictions of the hydrological model were used to fill gaps of measured data sets.     

Characterization of Dust Storms to Hong Kong in April 1998

In April 1998, two intense dust storms were generated in CentralAsia and transported eastward across East Asia (15 and 19 April). This article presents the chemical characterization ofHong Kong (HK) aerosols during the dust storms. During the 15 Aprildust storm, hourly respiratory suspended particles (RSP)(particle diameter smaller than 10 m) concentrationsmonitored at 7 sites in Hong Kong reached the peak valuessynchronously between 9 and 11 a.m. on 17 April, in which thehighest concentration was 267 g m^-3. Analysis ofthe RSP samples showed that concentrations of crustalelements (Ba, Ca, Cd, Cr, Fe, Mg, K⁺) and anthropogenicspecies (As, Ni, Pb, Zn, NH₄ ⁺, NO₃ ^-,SO₄ ^2- and total carbon) were substantiallyenhanced. Enhancement of these species was more than afactor of 2 to 14 relative to the non dust period. The totalcarbon content was high, at 59 g m^-3 (notincluding carbonate), and the enrichment factors of Asand Pb on 17 April were 122 and 117, respectively. Thisimplied that anthropogenic materials together with mineraldust were transported to HK from Mainland China. Based onmaterial balance calculations, mineral dust contributed41% to the observed RSP mass on 17 April, which was 2 times thatof the nondust sample (22%). From the 5-day backwardtrajectory analysis, this storm was transported directlyfrom Northwest China to HK. However, there was nocorresponding observation for the 19 April dust stormaerosol. Consequently, 15 April storm had stronger impact onHK's atmosphere than 19 April storm. Compared to the HK AirQuality Objective, 15 April dust storm did not cause seriousair pollution in HK.