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Kypros H. Nicolaides 《黑龙江环境通报》2011,31(1):7-15
Effective screening for major aneuploidies can be provided in the first trimester of pregnancy. Screening by a combination of fetal nuchal translucency and maternal serum free-β-human chorionic gonadotrophin and pregnancy-associated plasma protein-A can identify about 90% of fetuses with trisomy 21 and other major aneuploidies for a false-positive rate of 5%. Improvement in the performance of first-trimester screening can be achieved by firstly, inclusion in the ultrasound examination assessment of the nasal bone and flow in the ductus venosus, hepatic artery and across the tricuspid valve, and secondly, carrying out the biochemical test at 9 to 10 weeks and the ultrasound scan at 12 weeks. Copyright © 2011 John Wiley & Sons, Ltd. 相似文献
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Abdel Khalik H. El‐Sebae Mohamed M. Abou Zeid Fawzia H. Abdel‐Rahman Mahmoud A. Saleh 《Journal of environmental science and health. Part. B》2013,48(2):303-321
Abstract Human serum transferrin (HSTF), human serum albumin (HSA) and rat serum were compared for their interaction with AlCl3 , in a Tris‐HCl buffer solutions (pH 7.4). The AlCl3 was tested in series of concentrations in the range of 50 μM up to 500 μM . HSTF, HSA and their 1:1 mixture and rat serum were incubated at 37°C with series of AlCl3 concentrations. The protein profile of the incubated solutions were compared to control using SDS‐PAGE and FPLC tests. The results indicated that HSTF was more specifically responsive to AlCl3showing a characteristic increase in its UV absorption, peak and area dimensions. Simultaneously, HSA was less affected, but it showed a significant shift with an increase in molecular weight accompanied with a change in its profile. The respective bands of transferrin and albumin in rat serum behaved similarly. The SDS‐PAGE and FPLC data coincided and confirmed the preferential affinity of HSTF to bind with Al3+ . These results support the suggestion of using HSTF for monitoring levels of Al3+ in human blood samples of exposed population. The importance of further developing such a biomarker is the increased demand for early detection of the hazardous levels of Al3+ in relation to its long term neurotoxic adverse effects. 相似文献
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