Thiram‐induced toxic liver injury in male sprague‐dawley rats

Abstract

A single i.p. dose (120 mg/kg) of thiram given to male Sprague‐Dawley rats caused a significant increase in the activity of SGOT and SGPT 24 hr post‐treatment indicating liver damage. A considerable diminution in the serum cholinesterase activity was also noted in the treated rats as against the control animals. Additional evidence for thiram‐induced liver toxicity is provided by the observation that there was approximately 50% inhibition of the activity of hepatic microsomal benzphetamine N‐demethylase with a concomitant decrease in the concentration of cytochrome P‐450, an important component of the mixed‐function oxidase system. Although not significant, hepatic glutathione levels were also depleted by thiram, probably making the liver susceptible to toxic injury.     

甲胺磷农药废水生化处理高效菌选育的研究

从用甲胺磷农药废水长期驯化的活污泥中，筛选得到两株降解甲胺磷农药废水中有机磷的高效菌，经鉴定一株为蜡样芽孢杆菌（Ｂａｃｉｌｌｕｓｃｅｒｅｕｓ）。另一株为嗜中温假单胞菌（Ｐｓｅｕｄｏｍｏｎａｓｍｅｓｏｐｈｉｌｉｃａ）。确定了上述高效菌的最适生长条件和降解有机磷的能力，混合高效菌的有机磷去除率达９９．７％。