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排序方式: 共有348条查询结果,搜索用时 15 毫秒
11.
H. Brandenburg MD W. De Koning M. G. J. Jahoda Th. Stijnen M. A. J. De Ridder E. S. Sachs J. W. Wladimiroff 《黑龙江环境通报》1992,12(12):1031-1035
One hundred and fifty-one women of advanced maternal age who underwent genetic termination of pregnancy (TOP) were studied for their reproductive behaviour and the type of procedure for prenatal diagnosis in a subsequent pregnancy. A total of 59 women (39 per cent) had a further pregnancy. In all continuing pregnancies prenatal diagnosis was performed, of which 75 per cent consisted of chorionic villus sampling (CVS). Reproductive behaviour following a genetic termination was negatively correlated with maternal age and parity. Both reproductive behaviour and the choice to undergo a diagnostic procedure in the next pregnancy were independent of the type of diagnostic procedure in the previous affected pregnancy. 相似文献
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M. Zeitune D. A. Aitken J. A. Crossley J. R. W. Yates A. Cooke M. A. Ferguson-Smith 《黑龙江环境通报》1991,11(11):847-857
Risks appropriate for mid-trimester prenatal screening for autosomal trisomies have been estimated from a combination of maternal age and maternal serum (MS) alpha-fetoprotein (AFP) levels at 16–20 weeks gestation. Published data on the frequency of Down's syndrome births relative to maternal age were modified to include the additional age-related frequency of trisomy 18 and trisomy 13 cases to provide an overall risk for an autosomal trisomy at midtrimester. MSAFP results from a retrospective study of 142 affected (114 trisomy 21, 19 trisomy 18, and 9 trisomy 13)and 113 000 unaffected pregnancies were converted to multiples of the appropriate gestational median (MOM). The AFP levels in the autosomal trisomy pregnancies were found to be significantly reduced at 0.72 MOM of the unaffected pregnancies. Risks (likelihood ratios) were derived from the overlapping log Gaussian distributions for affected and unaffected pregnancies and combined with maternal age risks to give the overall odds of an affected pregnancy. A mid-trimester cut-off risk of 1:280 gave an estimated 37 per cent detection rate for autosomal trisomies in the west of Scotland population for a follow-up (false-positive) rate of 6.6 per cent. These figures compare with a 30 per cent detection and 6.7 per cent false-positive rate if age 35 years and over is used as the sole criterion for selection of at-risk pregnancies. 相似文献
14.
This study provides data on the incidence of fetal trisomies 21, 18, and 13 at 9–14 weeks' gestation in women aged 35–45 years and estimates of maternal age-specific risks in women aged 20–45 years. Our data from 5814 singleton pregnancies undergoing first-trimester karyotyping for the sole indication of maternal age ⩾ 35 years were combined with those from two previous reports and the incidence of the trisomies was calculated from a total of 15 793 pregnancies. Comparison of incidences at 9–14 weeks' gestation with published data at 15–20 weeks' gestation and in livebirths demonstrated that at birth the maternal age-specific incidence of trisomy 21 is 33 per cent lower than at 15–20 weeks' gestation and 54 per cent lower than at 9–14 weeks' gestation. Furthermore, the relative frequency of trisomies 18 and 13 decreases from 30 per cent at 9–14 weeks to 22 per cent at 15–20 weeks and 14 per cent at birth. 相似文献
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本文从不同方面和断代论述了中国东南地区的基底杂岩时代、性质、构造环境、边界变质条件、地球物理场及其反映的构造格局、断裂体系、中生代火山活动的基底构造及类型分区。在此基础上提出了东南地区的构造划分及构造演化阶段和格局。并提出了不同类型的地体及其分类、大陆裂解、增生的新概念。 相似文献
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The neonatal incidence rate of Down syndrome (DS) is well-known to accelerate strongly with maternal age. This non-linearity
renders mere accumulation of defects at recombination during prolonged first meiotic prophase implausible as an explanation
for DS rate increase with maternal age, but might be anticipated from chromosomal drive (CD) for trisomy 21. Alternatively,
as there is selection against genetically disadvantaged embryos, the screening system that eliminates embryos with trisomy
21 might decay with maternal age. In this paper, we provide the first evidence for relaxed filtering stringency (RFS) to represent
an adaptive maternal response that could explain accelerating DS rates with maternal age. Using historical data, we show that
the proportion of aberrant live births decrease with increased family size in older mothers, that inter-birth intervals are
longer before affected neonates than before normal ones, and that primiparae exhibit elevated levels of DS incidence at higher
age. These findings are predicted by adaptive RFS but cannot be explained by the currently available alternative non-adaptive
hypotheses, including CD. The identification of the relaxation control mechanism and therapeutic restoration of a stringent
screen may have considerable medical implications. 相似文献
19.
本研究利用火焰原子吸收法测定了重庆主城与郊区居民头发中镉、铜、镍、铅和锌等5种重金属的浓度水平,比较分析了人发中5种重金属含量水平及与年龄、性别和吸烟与否的关系,最后通过相关性分析和主成分分析初步了解重庆居民人发中重金属可能的来源.结果表明,重庆主城人发中Cd、Cu、Ni、Pb和Zn的平均含量分别为3.1、24.3、9.7、42.8和209.6 μg·g-1,郊区居民人发的平均含量分别为0.9、15.8、5.6、15.2和173.4 μg·g-1;5种重金属在主城居民头发中的含量均显著高于郊区居民头发中含量(t-检验,P<0.01),并且其组成与居民附近土壤样品的组成基本一致;5种重金属的含量在不同年龄段人群中的分布没有明显趋势,只是在郊区居民头发中的Cu和Zn含量随着年龄增长而减少;主城和郊区男性头发中Cd和Pb含量均显著高于女性(P<0.01),并且在主城和郊区吸烟者头发中的Cd和Pb显著高于非吸烟者(P<0.01);通过相关性分析发现主城和郊区中Cd、Cu、Ni和Pb之间具有相似的相关性模式,并且主成分分析结果显示,在主城中,人发Cu、Ni和Pb具有相似的来源,而在郊区中,人发Cd、Ni和Pb具有相似的来源. 相似文献
20.