The ductus venosus in early pregnancy and congenital anomalies

The ductus venosus (DV) is a tiny vessel leading oxygenated blood from the placenta to the fetal heart and its flow assessment has been used as an indicator of fetal acidemia. At 11 to 14 weeks, the fetuses with increased nuchal translucency also showing an abnormal DV blood flow were consistently found to be aneuploid. Early cardiac dysfunction, signaled by abnormal DV blood flow, was suggested as the underlying cause of increased nuchal translucency. Detection rates for aneuploidy with the use of DV blood flow studies range from 59 to 93% with 2 to 21% false-positive rates. In fetuses with normal karyotype, an abnormal DV flow pattern signals cardiac defects or adverse perinatal outcome. Copyright © 2004 John Wiley & Sons, Ltd.     

Trisomy 13 mosaicism: study of serial cytogenetic changes in a case from early pregnancy to infancy

We report a patient whose chorionic villus sampling showed a nonmosaic trisomy 13 [46,XX,der(13;13)(q10;q10)]. Subsequent amniocentesis and cordocentesis showed varying percentages of abnormal cells (77 and 78% in two amniocentesis; 14% in cordocentesis) and mosaic trisomy 13 was impressed. Prenatal fetal ultrasound scanning revealed only mild structural abnormalities (echogenic cardiac foci, transient lemon head, transient skin oedema). The mother chose to continue the pregnancy. Karyotyping of the cord blood, peripheral blood, umbilical cord, urine, and chorion were performed postpartum. The process of correction appeared to exist in the placenta (indirect evidence from coexistence of trisomy 13 [46,XX,der(13;13)(q10,q10)], euploidy [46,XX], aneuploidy [46,XX,–13, +mar], and monosomy 13 [45,XX,–13] in the chorion at birth). The baby had survived beyond eight months of age at the time of submission. Few structural abnormalities except low-set ears, absence of the 12th rib, and cardiomegaly with ventricular septal defect, were noted postnatally. The growth reached 95th percentile at the age of one month. Development milestones were not delayed at serial evaluations. Her ventricular septal defect was corrected surgically at the age of six months. Karyotypes of her skin fibroblasts, blood lymphocytes, and cardiac tissue were all normal [46,XX] at the time of surgery. Difficulties of the genetic counseling are also discussed. Copyright © 2004 John Wiley & Sons, Ltd.     

Screening for fetal aneuploidies at 11 to 13 weeks

Effective screening for major aneuploidies can be provided in the first trimester of pregnancy. Screening by a combination of fetal nuchal translucency and maternal serum free-β-human chorionic gonadotrophin and pregnancy-associated plasma protein-A can identify about 90% of fetuses with trisomy 21 and other major aneuploidies for a false-positive rate of 5%. Improvement in the performance of first-trimester screening can be achieved by firstly, inclusion in the ultrasound examination assessment of the nasal bone and flow in the ductus venosus, hepatic artery and across the tricuspid valve, and secondly, carrying out the biochemical test at 9 to 10 weeks and the ultrasound scan at 12 weeks. Copyright © 2011 John Wiley & Sons, Ltd.     

基于IPV6的嵌入式视频监控系统

本文通过分析IPv6嵌入式监控系统的研究现状及其实现方法,并结合应用实际,确定了采用具有TCP/IPv6网络协议栈的uClinux嵌入式实时操作系统,视频解压缩方而采用目前比较流行且成熟的MPEG-4技术,实现嵌入式视频监控系统在IPv6环境下的应用方案.论文重点研究了系统软件构架所采用的思想策略及实现,详细分析了RTP音视频传输系统实现策略和在DirectShow中的实现,给出了IPv6组播技术及安全策略的具体实现,最后给出了测试运行结果和结论.     

Prenatal diagnosis of complete trisomy 19q

This communication presents the first case of complete trisomy 19q, prenatally detected by ultrasound investigation. Real-time high-resolution ultrasound examination was performed at 19 weeks of gestation. After termination of the pregnancy, autopsy investigation was done. GTG-banding, fluorescence in situ hybridization m-(FISH) analysis, and FISH analysis with a 19q subtelomeric specific probe were used for identification of the fetal karyotype. Sonographic examination revealed an enlarged cisterna magna, cerebellar hypoplasia and aplasia of the inferior part of the vermis, combined and bilateral kidney malformations, significant nuchal fold, absence of fetal nasal bones, and intracardial calcifications. Autopsy confirmed ultrasound findings, but also revealed situs viscerum inversus of the lungs. Fetal karyotype was defined as: 46,XY,der(21)t(19;21)(q11;p13)mat. Our ultrasound and autopsy findings will certainly contribute to better knowledge of phenotype characterization of this rare chromosomal disorder. Copyright © 2007 John Wiley & Sons, Ltd.     

夏季大空间内火灾机械排烟效率的研究

采用全尺寸实验对夏季大空间内火灾机械排烟的效率进行了研究.实验过程中主要测量了火源功率和大空间内的烟气温度两个参数.通过分析大空间内烟气温度的分布规律,得到了机械排烟控制下不同火源功率的大空间内稳定的烟气层高度.根据Heskestad羽流模型计算了烟气生成速率,与机械排烟速率比较得到了夏季大空间内火灾机械排烟的效率.实验结果表明,在夏季大空间中,当火源功率不是很大时,大空间内外的温差使得外界补充进来的空气和火灾生成的烟气更加容易发生掺混,导致机械排烟的效率大大降低;按照规范规定的6次换气率进行排烟,在实验的300～1 000 kW的火源功率范围内,夏季大空间内火灾机械排烟的效率约为30%.火源功率的增大,在一定程度上削弱了空气与烟气的掺混,机械排烟的效率略有提高,但是提高的效果并不是很明显.     

基于STM32F103RBT6的振动信号采集系统

对一种监测振动信号采集系统进行了设计,系统以STM32F106RBT6型单片机为设计核心,并对传感器供电电路,信号调理电路,AD转换模块,通讯模块进行了分析。通过MATLAB对傅里叶变换进行了设计,对一些模拟信号进行了实测分析,实现了高精度模拟数据采集,可用于振动信号的采集,该振动信号采集系统具有功能强大,成本低,高精度,体积小等优点。