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Kevin Spencer 《黑龙江环境通报》2002,22(3):244-246
Over the past three years approximately 12 000 women have been screened in the first trimester through our OSCAR programme, which utilizes fetal NT and maternal serum free β-hCG and PAPP-A. During this time 30 cases of Down syndrome were identified either prenatally or postnatally. Using an established procedure the accuracy of predicted risk for Down syndrome was assessed in a population of 30 cases of Down syndrome and 11 758 unaffected pregnancies. The correlation between predicted risk and prevalence of Down syndrome was very high (r=0.9995). It is concluded that risks produced by the Fetal Medicine Foundation combined risk algorithm agree very closely with Down syndrome prevalence and can be used with confidence when counselling women of their risk. Copyright © 2002 John Wiley & Sons, Ltd. 相似文献
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The great majority of genetic defects underlying steroid 21-hydroxylase deficiency appear to result from intergenic recombinations between the homologous CYP21 and CYP21P genes. For a minority, novel sporadic point mutations have been detected. De novo mutations in CYP21 have also been reported, but only a few studies have systematically screened their occurrence. We here describe a population-based patient sample in order to estimate the rate of single-family (i.e. sporadic) and de novo germline mutations in the human CYP21 locus. Among 76 Finnish families were observed three single-family mutations and two de novo mutations in CYP21. The rates obtained, ∼5% and ∼2% for novel and de novo mutations, respectively, indicate that they are not rare and that their occurrence should not be ignored in genetic diagnostics of this disorder. Copyright © 2001 John Wiley & Sons, Ltd. 相似文献
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Kevin Spencer Adolfo W. Liao Charas Y. T. Ong Lut Geerts Kypros H. Nicolaides 《黑龙江环境通报》2001,21(6):441-444
Dimeric inhibin A was measured in maternal serum samples from 45 pregnancies affected by trisomy 21 and 493 samples from unaffected pregnancies at 10–14 weeks of gestation. Inhibin A levels in affected pregnancies were compared with levels of free β-hCG and PAPP-A in the same series. In the trisomy 21 group, the median multiple of the median (MoM) inhibin A was not significantly elevated (1.28 vs 1.00) with only 15.5% being above the 95th centile. In contrast, the median MoM free β-hCG was significantly increased (2.05 vs 1.00) with 36% above the 95th centile and PAPP-A was significantly reduced (0.49 vs 1.00) with 42% below the 5th centile. Inhibin A levels in the trisomy 21 group were significantly correlated with gestational age such that median levels rose from 1.04 at 11 weeks to 1.30 at 12 weeks and 1.67 at 13 weeks. These findings suggest that first trimester biochemical screening for trisomy 21, which is currently optimised using maternal serum free β-hCG and PAPP-A and fetal nuchal translucency, will not benefit from the inclusion of inhibin A. Copyright © 2001 John Wiley & Sons, Ltd. 相似文献
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测定了贵州高原喀斯特石漠化小流域内5种灌木叶片δ13C值的季节变化,旨在探讨季节及石漠化等级对植物叶片δ13C值的影响。结果表明:不同季节间植物叶片δ13C值呈显著差异,生长初期(4月)叶片的δ13C值显著高于生长中后期(7月、9月及12月);5种灌木种种间差异显著,火棘的叶片δ13C值最负,荚蒾的叶片δ13C值最正,粉枝莓,鼠李和竹叶椒的叶片δ13C值居中;7月不同石漠化等级间植物叶片δ13C值存在显著差异,而在其余月份(即4月、9月及12月)不同石漠化等级间植物叶片δ13C值不存在显著差异,但基本呈现无、轻度石漠化植物叶片小于中度石漠化植物叶片δ13C值的格局;整个生长季中,叶片δ13C值与土壤含水量的相关关系研究表明大多数种在大多数时间随土壤水分的减少其δ13C值增高。 相似文献
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