浅谈环境保护行政处罚中告知程序

本文根据《行政处罚法》的要求，阐述了环境保护行政处罚告知在履地中的问题和加强这一工作的具体措施与步骤，有较强的操作性，指导性与实践性。     

Prenatal diagnosis of autosomal dominant polycystic kidney disease using flanking DNA markers and the polymerase chain reaction

A prenatal diagnosis was carried out on a 9-week-old fetus at risk for autosomal dominant polycystic kidney disease (ADPKD). Ten members of the family were previously typed using five DNA markers linked to the PKD1 locus on chromosome 16, and one marker linked to the putative PKD2 locus on chromosome 2. The polymerase chain reaction (PCR) was used to amplify the D16S125 locus. Pairwise and multipoint lod scores indicated that the family was most likely segregating a PKD1 mutation. The fetus inherited the disease haplotype from the affected parent. Diagnostic accuracy was greater than 99 per cent, taking into account the possibility of genetic heterogeneity.     

The dilemma of a low rate of chromosomal mosaicism found in fetal blood sampling

We report a case in which mosaicism of trisomy 13 was detected in 4/10 cells (40 per cent) in amniotic fluid cell cultures, followed by a low rate of mosaicism (1/160 cells) detected in a fetal blood sample. This finding presents a dilemma both for the genetic counsellor and for the parents in determining whether or not to terminate the pregnancy.     

Anxiety in women with low maternal serum alpha-fetoprotein screening results

The purpose of this study was to measure anxiety in pregnant women who had low maternal serum alpha-fetoprotein (MSAFP) screening test levels, received genetic counselling and chose to undergo amniocentesis for fetal chromosome analysis. Their anxiety levels were compared with the levels in women undergoing amniocentesis because of advanced maternal age. The results indicate a higher level of anxiety in women with low alpha-fetoprotein (AFP) levels.     

Pericentric inversion of chromosome 19: prenatal diagnosis and genetic counselling

During prenatal diagnosis for advanced maternal age, a pericentric inversion of a chromosome 19 was detected in a male fetus. The inversion was familial, transmitted to the fetus by the phenotypically normal mother. The pregnancy resulted in a term birth of a phenotypically normal male infant. Inversion 19 appears to be a rare abnormality with only seven families reported thus far including ours. Infants with duplication deficiencies for chromosome 19 have not been reported in these families. This may suggest an apparent suppression of crossing over and recombination within the inverted segment of chromosome 19 during meiosis.     

高速公路建设项目清洁生产初探

首先介绍了清洁生产的发展概况，然后论述了高速公路建设项目实施清洁生产的意义，最后从环境管理、清洁生产审计、实施方案3个方面论述了实施清洁生产的途径。     

Five cases of prenatally diagnosed sex chromosome mosaicism

Prenatal detection of chromosome mosaicism is a relatively rare phenomenon and always constitutes a diagnostic problem. The difficulties are much more when the mosaics involve the sex chromosomes, because of the large phenotypic variability in individuals with these abnormalities. We studied 5 cases of true mosaics, 4 of these were prenatally detected, while 1 case was revealed only in the fetal lymphocytes after induced abortion. The limits of amniotic fluid culture with regard to the diagnosis of true mosaics and the difficulties arising in genetic counselling are discussed.     

Mid-trimester fetal ultrasound: Diagnostic dilemmas

Two cases are reported in which an unusual ultrasound finding preceded diagnostic amniocentesis and led to further work-up. In both cases a decision was made to terminate the pregnancy. One fetus in which a neck mass was detected by ultrasound was shown to be normal on post-mortem examination. The second fetus was aborted because of Rh sensitization and had the abnormality seen by ultrasound. However, this lesion, calcified intrahepatic plaques, had no presumed pathological significance. These cases suggest caution in the interpretation of results obtained with the new technologies used for prenatal diagnosis.     

上海市在用车I／M计划管理体系的探讨

在用机动车监测与维修制度（I／M计划）是减少机动车污染排放的最主要措施。借鉴美国I／M计划取得的经验，提出上海市在用车I／M 计划管理体系，建立上海市I／M 计划管理中心和监测 中心。     

云南易门狮山铜矿床的喷气沉积成因

本文讨论了云南易门狮山铜矿床的地质背景、含矿建造、火山岩及矿床地质地球化学特征。成矿地质背景为中元古代后期的裂陷槽。含矿建造为火山沉积黑色页岩碳酸盐含铜建造。胶状、变胶状黄铁矿及黄铜矿砂状碎屑构造是矿床同生成因的新证据。建立了海底喷气沉积矿床成因模式,论述了狮山铜矿床的成矿作用。