氟化物对工人淋巴细胞SCE的诱发

研究表明,磷肥生产中向空气排放的氟化氢和四氟化硅可诱发人血淋巴细胞SCE增高,可使细胞有丝分裂指数下降,使细胞分裂周期迟缓。随接触年限的增加,SCE频率提高。然而接触氟空气污染约10年左右,人体对氟损害所产生的适应机制能够显著降低氟对遗传物质所造成的损伤。吸烟可加重氟化物对SCE的诱发,且吸烟年限越长,这种效应就越显著。     

APPLICATION OF PARAMETER OPTIMIZATION METHOD FOR CALIBRATING TANK MODEL1

ABSTRACT: Many automatic calibration processes have been proposed to efficiently calibrate the 16 parameters involved in the four‐layered tank model. The Multistart Powell and Stuffed Complex Evolution (SCE) methods are considered the best two procedures. Two rainfall events were designed to compare the performance and efficiency of these two methods. The first rainfall event is short term and the second designed for long term rainfall data collection. Both rainfall events include a lengthy no‐rainfall period. Two sets of upper and lower values for the search range were selected for the numerical tests. The results show that the Multistart Powell and SCE methods are able to obtain the true values for the 16 parameters with a sufficiently long no‐rainfall period after a rainfall event. In addition, by using two selected objective functions, one based on root mean square error and one based on root mean square relative error criteria, it is found that the no‐rainfall period lengths necessary to obtain the converged true values for the 16 parameters are roughly the same. The SCE method provides a more efficient search based on an appropriate preliminary search range. The Multistart Powell method, on the other hand, leads to more accurate search results when there is no suitable search range selected based on the parameter calibration experience.